Page 69 - AN-2-3

Advanced Neurology Voluntary running effects in PTEN knockout mouse

autism spectrum disorders in a total population sample. Am memory and synaptic plasticity in a mouse model of
J Psychiatry, 168: 904–912. Alzheimer’s disease. J Neurosci, 35: 14042–14056.
https://doi.org/10.1176/appi.ajp.2011.10101532 https://doi.org/10.1523/JNEUROSCI.2781-15.2015
65. Liu G, Feng D, Wang J, et al., 2018, rTMS ameliorates PTSD 76. Rothman SM, Olney JW, 1986, Glutamate and the
symptoms in rats by enhancing glutamate transmission and pathophysiology of hypoxic-ischemic brain damage. Ann
synaptic plasticity in the ACC via the PTEN/AKT signaling Neurol, 19: 105–111.
pathway. Mol Neurobiol, 55: 3946–3958.
https://doi.org/10.1002/ana.410190202
https://doi.org/10.1007/s12035-017-0602-7
77. Lenz G, Avruch J, 2005, Glutamatergic regulation of the
66. Rubenstein JLR, 2010, Three hypotheses for developmental p70S6kinase in primary mouse neurons. J Biol Chem,
defects that may underlie some forms of autism spectrum 280: 38121–38124.
disorder. Curr Opin Neurol, 23: 118–123.
https://doi.org/10.1074/jbc.C500363200
https://doi.org/10.1097/WCO.0b013e328336eb13
78. Weston MC, Chen H, Swann JW, 2012, Multiple roles
67. Marchese M, Conti V, Valvo G, et al., 2014, Autism-epilepsy for mammalian target of rapamycin signaling in both
phenotype with macrocephaly suggests PTEN, but not glutamatergic and GABAergic synaptic transmission.
GLIALCAM genetic screening. BMC Med Genet, 15: 26. J Neurosci, 32: 11441–11452.
68. Christensen J, Gronborg TK, Sorensen MJ, et al., 2013, https://doi.org/10.1523/JNEUROSCI.1283-12.2012
Prenatal valproate exposure and risk of autism spectrum 79. Williams MR, DeSpenza T Jr., Li M, et al., 2015, Hyperactivity
disorders and childhood autism. JAMA, 309: 1696–1703.
of newborn PTEN knock-out neurons results from increased
https://doi.org/10.1001/jama.2013.2270 excitatory synaptic drive. J Neurosci, 35: 943–959.
69. Bescoby-Chambers N, Forster P, Bates G, et al., 2001, Foetal https://doi.org/10.1523/JNEUROSCI.3144-14.2015
valproate syndrome and autism: Additional evidence of an 80. Antion MD, Merhav M, Hoeffer CA, et al., 2008, Removal
association. Dev Med Child Neurol, 43: 847.
of S6K1 and S6K2 leads to divergent alterations in learning,
https://doi.org/10.1017/s0012162201211542 memory, and synaptic plasticity. Learn Mem, 15: 29–38.
70. Rinaldi T, Kulangara K, Antoniello K, et al., 2007, Elevated https://doi.org/10.1101/lm.661908
NMDA receptor levels and enhanced postsynaptic long- 81. Cammalleri M, Lutjens R, Berton F, et al., 2003, Time-
term potentiation induced by prenatal exposure to valproic restricted role for dendritic activation of the mTOR-
acid. Proc Natl Acad Sci U S A, 104: 13501–13506.
p70S6K pathway in the induction of late-phase long-term
https://doi.org/10.1073/pnas.0704391104 potentiation in the CA1. Proc Natl Acad Sci U S A,
100: 14368–14373.
71. Wang X, Kery R, Xiong Q, et al., 2018, Synaptopathology
in autism spectrum disorders: Complex effects of synaptic https://doi.org/10.1073/pnas.2336098100
genes on neural circuits. Prog Neuropsychopharmacol Biol 82. Raymond CR, Redman SJ, Crouch MF, 2002, The
Psychiatry, 84: 398–415.
phosphoinositide 3-kinase and p70 S6 kinase regulate long-
https://doi.org/10.1016/j.pnpbp.2017.09.026 term potentiation in hippocampal neurons. Neuroscience,
109: 531–536.
72. Fenton TR, Gout IT, 2011, Functions and regulation of
the 70kDa ribosomal S6 kinase. Int J Biochem Cell Biol, https://doi.org/10.1016/s0306-4522(01)00500-0
43: 47–59.
83. Paez JG, Sellers WR, 2003, PI3K/PTEN/AKT pathway. A
https://doi.org/10.1016/j.biocel.2010.09.018 critical mediator of oncogenic signaling. Cancer Treat Res,
115: 145–167.
73. Baar K, Esser K, 1999, Phosphorylation of p70(S6k)
correlates with increased skeletal muscle mass following 84. Yu M, King B, Ewert E, et al., 2016, Exercise activates p53
resistance exercise. Am J Physiol, 276: C120–C127. and negatively regulates IGF-1 pathway in epidermis within
a skin cancer model. PLoS One, 11: e0160939.
https://doi.org/10.1152/ajpcell.1999.276.1.C120
https://doi.org/10.1371/journal.pone.0160939
74. Terzis G, Spengos K, Mascher H, et al., 2010, The degree of
p70S6k and S6 phosphorylation in human skeletal muscle 85. Gonzalez MD, Buberman A, Morales M, et al., 2021,
in response to resistance exercise depends on the training Aberrant synaptic PTEN in symptomatic Alzheimer’s
volume. Eur J Appl Physiol, 110: 835–843. patients may link synaptic depression to network failure.
Front Synaptic Neurosci, 13: 683290.
https://doi.org/10.1007/s00421-010-1527-2
https://doi.org/10.3389/fnsyn.2021.683290
75. Caccamo A, Branca C, Talboom JS, et al., 2015, Reducing
ribosomal protein S6 kinase 1 expression improves spatial 86. Rosenfeld CS, 2017, Sex-dependent differences in voluntary

Volume 2 Issue 3 (2023) 14 https://doi.org/10.36922/an.0872