Page 46 - AN-3-1

Advanced Neurology Antibodies as neurodegenerative biomarkers

doi: 10.1038/s41593-020-0624-8 doi: 10.1007/s00401-017-1745-3
39. Lee CYD, Daggett A, Gu X, et al. Elevated TREM2 gene 50. Ma H, Murphy C, Loscher CE, O’Kennedy R.
dosage reprograms microglia responsivity and ameliorates RAutoantibodies-enemies, and/or potential allies? Front
pathological phenotypes in Alzheimer’s disease models. Immunol. 2022;13:953726.
Neuron. 2018;97(5):1032-1048.e5.
doi: 10.3389/fimmu.2022.953726
doi: 10.1016/j.neuron.2018.02.002
51. Cocco C, Manca E, Corda G, et al. Brain-reactive
40. Wang Y, Cella M, Mallinson K, et al. TREM2 lipid sensing autoantibodies in neuropsychiatric systemic lupus
sustains the microglial response in an Alzheimer’s disease erythematosus. Front Immunol. 2023;14:1157149.
model. Cell. 2015;160(6):1061-1071.
doi: 10.3389/fimmu.2023.1157149
doi: 10.1016/j.cell.2015.01.049
52. Mader S, Brimberg L, Diamond B. The role of brain-
41. Jay TR, Hirsch AM, Broihier ML, et al. Disease progression- reactive autoantibodies in brain pathology and cognitive
dependent effects of TREM2 deficiency in a mouse model of impairment. Front Immunol. 2017;8:1101.
Alzheimer’s disease. J Neurosci. 2017;37(3):637-647.
doi: 10.3389/fimmu.2017.01101
doi: 10.1523/JNEUROSCI.2110-16.2016
53. Graus F, Dalmau J. Paraneoplastic neurological syndromes
42. Labzin LI, Heneka MT, Latz E. Innate immunity and in the era of immune-checkpoint inhibitors. Nat Rev Clin
neurodegeneration. Annu Rev Med. 2018;69:437-449. Oncol. 2019;16(9):535-548.
doi: 10.1146/annurev-med-050715 doi: 10.1038/s41571-019-0194-4
43. DeMaio A, Mehrotra S, Sambamurti K, Husain S. The role 54. Daguano Gastaldi V, BH Wilke J, Weidinger CA, et al.
of the adaptive immune system and T cell dysfunction Factors predisposing to humoral autoimmunity against
in neurodegenerative diseases. J Neuroinflammation. brain-antigens in health and disease: Analysis of 49
2022;19(1):251.
autoantibodies in over 7000 subjects. Brain Behav Immun.
doi: 10.1186/S12974-022-02605-9 2023;108:135-147.
44. Cunningham MW. Molecular mimicry, autoimmunity, and doi: 10.1016/J.BBI.2022.10.016
infection: The cross-reactive antigens of group a Streptococci 55. Hohlfeld R, Dornmair K, Meinl E, Wekerle H. The search for
and their Sequelae. Microbiol Spectr. 2019;7(4):10-1128.
the target antigens of multiple sclerosis, part 2: CD8+ T cells,
doi: 10.1128/microbiolspec.gpp3-0045-2018 B cells, and antibodies in the focus of reverse-translational
research. Lancet Neurol. 2016;15(3):317-331.
45. Wang L, Wang FS, Gershwin ME. Human autoimmune
diseases: A comprehensive update. J Intern Med. doi: 10.1016/S1474-4422(15)00313-0
2015;278(4):369-395.
56. Van Coevorden-Hameete MH, Titulaer MJ, Schreurs MWJ,
doi: 10.1111/JOIM.12395 de Graaff E, Sillevis Smitt PAE, Hoogenraad CC. Detection
46. Levin EC, Acharya NK, Han M, et al. Brain-reactive and characterization of autoantibodies to neuronal cell-
autoantibodies are nearly ubiquitous in human sera and may surface antigens in the central nervous system. Front Mol
be linked to pathology in the context of blood-brain barrier Neurosci. 2016;9:197972.
breakdown. Brain Res. 2010;1345:221-232. doi: 10.3389/FNMOL.2016.00037/BIBTEX
doi: 10.1016/j.brainres.2010.05.038 57. Yin J, Ibrahim S, Petersen F, Yu X. Autoimmunomic
47. Webb NE, Bernshtein B, Alter G. Tissues: The unexplored signatures of aging and age-related neurodegenerative
frontier of antibody mediated immunity. Curr Opin Virol. diseases are associated with brain function and ribosomal
2021;47:52-67. proteins. Front Aging Neurosci. 2021;13:679688.
doi: 10.1016/j.coviro.2021.01.001 doi: 10.3389/FNAGI.2021.679688
48. Nagaraj V, Theis T, Johal AS, et al. Application of antibodies 58. Hansen N, Malchow B, Zerr I, Stöcker W, Wiltfang J, Timäus
to neuronally expressed nogo-a increases neuronal survival C. Neural cell-surface and intracellular autoantibodies in
and neurite outgrowth. Int J Mol Sci. 2020;21(15):5417. patients with cognitive impairment from a memory clinic
cohort. J Neural Transm (Vienna). 2021;128(3):357.
doi: 10.3390/ijms21155417
doi: 10.1007/S00702-021-02316-0
49. Ineichen BV, Kapitza S, Bleul C, et al. Nogo-A
antibodies enhance axonal repair and remyelination in 59. Arshad F, Varghese F, Paplikar A, et al. Role of Autoantibodies
neuro-inflammatory and demyelinating pathology. Acta in Neurodegenerative Dementia: An Emerging Association.
Neuropathol. 2017;134(3):423-440. Dement Geriatr Cogn Disord. 2021;50(2):153-160.

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