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Advances in Radiotherapy
& Nuclear Medicine Advancements and challenges in radioactive iodine-125

are primarily based on expert clinical experience and lack Supervision: Ping Jiang, Junjie Wang
large-scale multicenter clinical studies. Writing – original draft: Liting Xiong, Yuhan Yang,
On the other hand, the development of I-125 Chunxiao
brachytherapy must also consider spatial orientation, Writing – review and editing: Chunxiao Li
All authors have agreed to the final manuscript and
focusing on optimizing the path for radiation source
implantation. Besides targeting the tumor site, the role of approved the submitted version.
the operator in brachytherapy should not be overlooked. The Ethics approval and consent to participate
introduction of 3D-printed personalized templates has been
conducive to achieving personalized treatment and reducing Not applicable.
dependence on operator experience. In addition, robot- Consent for publication
assisted systems provide solutions for the puncture challenges
in brachytherapy across various tumor sites through Not applicable.
mechanical automation-assisted needle implantation.
However, recent research on robotic technology in the field Availability of data
of brachytherapy has mainly focused on prostate cancer and Not applicable.
radioactive particle implantation, with insufficient attention
given to other diseases suitable for brachytherapy. References

In the future, robotic system technologies can be 1. Parker SL, 1997, Cancer statistics, 1997. CA Cancer J Clin,
leveraged to their full potential to realize precise and remote 47: 5–27.
medical treatment for brachytherapy. Preliminary research https://doi.org/10.3322/canjclin.47.1.5
indicates that the combined treatment of brachytherapy and 2. Rosenberg I, 2008, Radiation oncology physics: A handbook
immunotherapy demonstrates favorable tolerability and for teachers and students. Br J Cancer, 98: 1020.
warrants further investigation. However, several unresolved
issues remain regarding the optimal method of coordinating https://doi.org/10.1038/sj.bjc.6604224
these two treatments, including duration and radiation 3. Yoshioka Y, 2009, Current status and perspectives of
dose. Moreover, additional preclinical and clinical studies brachytherapy for prostate cancer. Int J Clin Oncol, 14: 31–36.
are imperative to gain a comprehensive understanding of https://doi.org/10.1007/s10147-008-0866-z
the immune regulatory effects of I-125 brachytherapy.
4. Torp-Pedersen S, Holm HH, Littrup PJ, 1987, Transperineal
Acknowledgments I-125 seed implantation in prostate cancer guided by
transrectal ultrasound. Prog Clin Biol Res, 237: 143–152.
None.
5. Ji Z, Jiang Y, Guo F, et al., 2020, Safety and efficacy of
Funding CT-guided radioactive iodine-125 seed implantation assisted
by a 3D printing template for the treatment of thoracic
This work was funded by the National Natural Science malignancies. J Cancer Res Clin Oncol, 146: 229–236.
Foundation of China (grants 82173174 to C. Li and https://doi.org/10.1007/s00432-019-03050-7
82073335 to J. Wang), the Natural Science Foundation of
Beijing Municipality (grants 7232207 to C. Li), Intramural 6. Ji Z, Jiang Y, Tian S, et al., 2019, The effectiveness and
prognostic factors of CT-guided radioactive I-125 seed
funding from the Beijing University Third Hospital (grant implantation for the treatment of recurrent head and neck
BYSY2022044 to C. Li), the Special Fund of the National cancer after external beam radiation therapy. Int J Radiat
Clinical Key Specialty Construction Program, P. R. China Oncol Biol Phys, 103: 638–645.
(2021), and the Cancer Precision Radiotherapy Spark
Program of China International Medical Foundation https://doi.org/10.1016/j.ijrobp.2018.10.034
(grant number: 2019-N-11-13). 7. Wang H, Wang J, Jiang Y, et al., 2013, The investigation of
125I seed implantation as a salvage modality for unresectable
Conflict of interest pancreatic carcinoma. J Exp Clin Cancer Res, 32: 106.

The authors declare no potential conflicts of interest. https://doi.org/10.1186/1756-9966-32-106
8. Wang J, Yuan H, Ma Q, et al., 2010, Interstitial 125I seeds
Author contributions implantation to treat spinal metastatic and primary

Conceptualization: Chunxiao Li paraspinal malignancies. Med Oncol, 27: 319–326.
Investigation: Mengyuan Li https://doi.org/10.1007/s12032-009-9212-1

Volume 1 Issue 2 (2023) 9 https://doi.org/10.36922/arnm.0914