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Brain & Heart Cardiac sarcoidosis with AVB and VA

Table 2. (Continued)
Author Place of Type of study No. of No. of patients Endpoints/outcomes Key findings
study patients with with VAs
AVB
Ahmed et al. United Retrospective 2 3 Outcomes examined were Infliximab was associated with a
2023 36 Kingdom single-center cohort findings on follow-up reduction in disease activity on
18F-FDG PET and follow-up 18F-FDG PET and an
echocardiography, steroid improvement of LVEF, with no
maintenance dose, significant arrhythmic events during
morbidity, and mortality follow-up. It was associated with an
increased likelihood of infection
Mohsen et al. USA Retrospective - 12 Recorded outcomes were Glucocorticoid therapy did not
2014 40 single-center cohort death and delivery of ICD prevent appropriate or inappropriate
therapies ICD shock delivery. No specific
markers were associated with
malignant VAs in CS
Nordenswan Finland Case–control study 143 20 patients who Endpoint was sudden Patients with CS who presented with
et al. 2018 41 presented with cardiac death (fatal or AVB have a high risk of sudden cardiac
AVB aborted) death. Patients presenting with AVB
alone often had delayed diagnosis of
CS and were most likely to require
transplantation. Incidence of VT was
24% at 5 years after presentation
Mathijssen Netherlands Retrospective 46 19 Primary outcome was Prior VA and right ventricular
et al. 2022 44 single-center cohort appropriate ICD therapy LGE were predictors of ICD
delivery therapy delivery, and low rates of
inappropriate therapies were observed
Azoulay et al. Japan, Meta-analysis Not stated Not stated Outcome measured was Age, male sex, LVEF, complete
2020 45 Europe, appropriate ICD therapy heart block, and ventricular pacing
USA delivery were associated with the delivery of
appropriate ICD therapy
Jefic et al. USA Retrospective - 42 Endpoint was elimination VT ablation can be effective in
2009 47 multicenter cohort of VA eliminating or reducing VT burden
in cases refractory to medical therapy
Siontis et al. USA, Retrospective 36 158 Immediate and Catheter ablation shown to be
2022 48 Europe, multicenter cohort short-term outcomes effective in treating medically
Japan included procedural resistant VT and reducing
success, elimination defibrillator shocks and recurrent
of VT storm, and VT storm
reduction in defibrillator
shocks. The primary
long-term outcome
was the composite of
VT recurrence, heart
transplant, or death
Muser et al. USA Retrospective - 31 Long-term outcomes Active inflammation at the time of
2016 51 single-center cohort were VT-free survival, VT ablation is associated with higher
reduction, death, or heart relapse rates, but VT ablation is
transplant overall effective in CS
Ahmed et al. 52 United Retrospective 77 - Endpoints were all-cause A late diagnosis of CS was associated
Kingdom single-center cohort mortality, cardiac with worse outcomes as well as a
transplant, VA, or higher required steroid dose and
hospitalization for heart a higher likelihood of requiring
failure. Maintenance cardiac device upgrade
steroid dose and cardiac
device upgrades and
complications were
evaluated
(Cont’d...)

Volume 2 Issue 4 (2024) 6 doi: 10.36922/bh.3515