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Brain & Heart                                                             Neurologic manifestations of IBD



            of IBD. Early recognition and appropriate management   3.   Benavente L, Morís G. Neurologic disorders associated with
            of neurological symptoms can significantly improve    inflammatory bowel disease. Eur J Neurol. 2011;18(1):138-143.
            patient outcomes. Moreover, ongoing research into the      doi: 10.1111/j.1468-1331.2010.03095.x
            mechanisms linking IBD with neurological complications
            will  be  vital  for  developing  more effective  strategies  for   4.   Lossos A, River Y, Eliakim A, Steiner I. Neurologic
                                                                  aspects of inflammatory bowel disease.  Neurology.
            prevention and treatment.                             1995;45(3 Pt 1):416-421.
              Ultimately, enhancing our understanding of the      doi: 10.1212/wnl.45.3.416
            neurological manifestations of IBD will lead to more
            comprehensive care strategies, which reduce the burden of   5.   Morís G. Inflammatory bowel disease: An increased risk
                                                                  factor for neurologic complications. World J Gastroenterol.
            these complications on patients and improve their overall   2014;20(5):1228-1237.
            quality of life. As such, continued interdisciplinary research
            collaboration is essential to advance our knowledge and      doi: 10.3748/wjg.v20.i5.1228
            improve the techniques used in managing patients with   6.   Elsehety A, Bertorini TE. Neurologic and neuropsychiatric
            these complications.                                  complications of Crohn’s disease.  South Med J.
                                                                  1997;90(6):606-610.
            Acknowledgments
                                                                  doi: 10.1097/00007611-199706000-00005
            None.
                                                               7.   Sassi SB, Kallel L, Ben Romdhane S, Boubaker J, Filali A,
            Funding                                               Hentati F. Peripheral neuropathy in inflammatory bowel
                                                                  disease patients: A  prospective cohort study.  Scand J
            None.                                                 Gastroenterol. 2009;44(10):1268-1269.
            Conflict of interest                                  doi: 10.1080/00365520903199871
                                                               8.   Oliveira  GR,  Teles  BCV,  Brasil  EF,  et al.  Peripheral
            The authors declare they have no competing interests.  neuropathy and neurological disorders in an unselected
            Author contributions                                  Brazilian population-based cohort of IBD patients. Inflamm
                                                                  Bowel Dis. 2008;14(3):389-395.
            Conceptualization: Manjeet Kumar Goyal, Ashita Rukmini      doi: 10.1002/ibd.20304
               Vuthaluru
            Writing–original draft: Manjeet Kumar Goyal, Ashita   9.   Geissler A, Andus T, Roth M,  et al. Focal white-matter
                                                                  lesions in brain of patients with inflammatory bowel disease.
               Rukmini Vuthaluru                                  Lancet. 1995;345(8954):897-898.
            Writing–review & editing: Shivam  Kalra, Abhinav  Rao,
               Abhinav Gupta, Manisha Khubber                     doi: 10.1016/s0140-6736(95)90013-6
                                                               10.  Zikou AK, Kosmidou M, Astrakas LG, Tzarouchi LC,
            Ethics approval and consent to participate            Tsianos E, Argyropoulou MI. Brain involvement in
            Not applicable.                                       patients with inflammatory bowel disease: A  voxel-based
                                                                  morphometry  and  diffusion tensor  imaging study.  Eur
            Consent for publication                               Radiol. 2014;24(10):2499-2506.
            Not applicable.                                       doi: 10.1007/s00330-014-3242-6
                                                               11.  Singh  A, Goyal  MK, Midha  V,  et al. Tofacitinib in  acute
            Availability of data                                  severe ulcerative colitis (TACOS): A randomized controlled
            Not applicable.                                       trial. Am Coll Gastroenterol. 2024;119:1365-1372.
                                                                  doi: 10.14309/ajg.0000000000002635
            References
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                                                               13.  Ferro JM, Oliveira SN, Correia L. Neurologic manifestations
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            Volume 2 Issue 4 (2024)                         9                                doi: 10.36922/bh.3486
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