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Global Health Economics and
            Sustainability
                                                                                   OAT in Central Asia: Kyrgyz Republic



            Table 1. (Continued)
            Year     Policy change            Activities        OAT Census               Source
                                                                  (Sites)
            2015     Order 372     Creates a working group to revise the   Approx. 1200  (Instructions on Implementation of Methadone
                                   methadone treatment clinical protocol.   (31)  Maintenance Therapy and Needle and Syringe Programs
                                   New guidelines recommend maintenance   in Institutions of the State Penitentiary Service under
                                   doses as low as 60 mg for most patients   the Government of the Kyrgyz Republic, 2015; On the
                                   and prohibit take-home dosing.        Creation of a Working Group for the Revision of the
                                                                         Clinical Protocol “Treatment of Opioid Dependence
                                                                         Based on Maintenance Therapy with Methadone”, 2015;
                                                                         Republican Narcology Center, 2015; Subata et al., 2015)
            2016     Orders 161, 637  Order 637 abolishes the State Drug   1505 (31)  (On Additional Measures for Counteraction of Illicit
                                   Control Service, a law enforcement    Trafficking of Narcotic Drugs, Psychotropic Substances
                                   branch focused on trafficking and drug   and Precursors, 2011; On Measures to Reform the
                                   use through punitive measures. Order   System of Law Enforcement Agencies of the Kyrgyz
                                   161 establishes that illicit drug trafficking   Republic, 2016; On the Liquidation of the State Drug
                                   will be regulated by the Ministry of   Control Service under the Government of the Kyrgyz
                                   Internal Affairs and legal circulation of   Republic, 2016; Republican Narcology Center of the
                                   narcotic drugs including methadone will   Ministry of Health of the Kyrgyz Republic, 2016)
                                   be regulated by the Ministry of Health.
                                   This creates a more public-health-based
                                   approach to drug regulation.
                                   In 2016, the government produced its
                                   first training manual for dispensing
                                   methadone by nurses.
            2017     Orders 584, 625,   Order 584 introduces a clinical protocol   1455 (29)  (On Amendments to the Regulations “On the
                     1082, 131     for children and adolescents with     Conditions and Procedure for Conducting Methadone
                                   substance use disorders, allowing     Maintenance Therapy for Persons Who Inject Drugs
                                   treatment of OUD in minors. Order     in the Kyrgyz Republic”, 2017; On the Conditions and
                                   625 allows oversight of the methadone   Procedure for Conducting Methadone Maintenance
                                   program. Order 1082 allows methadone   Therapy for People Who Use Injection Drugs in
                                   treatment in inpatient facilities and   the Kyrgyz Republic, 2017; On the Implementation
                                   introduces take-home dosing for select   of Orders of the Ministry of Health of the Kyrgyz
                                   patients for up to five days, and Order 131   Republic No. 625 Dated July 17, 2017, and No. 1082
                                   provides guidance on how to implement   Dated November 28, 2017, 2017; Republican Narcology
                                   Orders 625 and 1082.                  Center of the Ministry of Health of the Kyrgyz
                                                                         Republic, 2017)
            2019     Orders 542, 749  Permit PWH to seek HIV services outside   1123 (24)  (On Approval of Mechanisms for Decentralization
                                   of specialized clinics, including receiving   of Medical Services for People Living with Human
                                   antiretroviral medications at methadone   Immunodeficiency Virus in the Kyrgyz Republic, 2019;
                                   sites. These orders also provide a clinical   Republican Narcology Center of the Ministry of Health
                                   protocol for people who use opioids and   of the Kyrgyz Republic, 2019)
                                   alcohol.
            2020     Order 28      Expands take-home dosing of methadone   979 (24)  (On Measures to Prevent Coronavirus Infections
                                   during the COVID-19 pandemic to       (COVID-19), 2020)
                                   mitigate community transmission of
                                   COVID. Allows take-home dosing for up
                                   to five days for patients whose relatives
                                   apply on their behalf with identifying
                                   documents.
            2022     Order 1471    Updates official guidelines for OAT,   850 (24)  (Ministry of Health of the Kyrgyz Republic and
                                   incorporating input from international   Republican Centre for Psychiatry and Narcology, 2022)
                                   experts. The updated guidelines target
                                   higher dosing, earlier transition to
                                   take-home dosing, and faster induction
                                   strategies. For the first time, guidelines for
                                   buprenorphine treatment are introduced.
            Abbreviations: HIV: Human immunodeficiency virus; OAT: Opioid agonist therapies; OUD: Opioid use disorder; PWH: People with HIV;
            PWID: People who inject drugs.



            Volume 2 Issue 4 (2024)                         4                        https://doi.org/10.36922/ghes.2536
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