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Gene & Protein in Disease Autoimmune thyroid disease in narcolepsy

sufficient data to demonstrate whether AITD is more 4. Andlauer O, Moore HT 4 , Hong SC, et al., 2012, Predictors
th
likely to occur in narcolepsy patients. Therefore, the of hypocretin (orexin) deficiency in narcolepsy without
future studies should focus on autoimmune disorders cataplexy. Sleep, 35(9): 1247–1255F.
in larger sample sizes of narcolepsy patients to explore https://doi.org/10.5665/sleep.2080
the pathophysiological mechanisms of narcolepsy with 5. Liblau RS, Vassalli A, Seifinejad A, et al., 2015, Hypocretin
immunopathological diseases. This would allow us to (orexin) biology and the pathophysiology of narcolepsy with
better understand the significance of immune-related cataplexy. Lancet Neurol, 14(3): 318–328.
processes in the pathophysiology of these disorders.
https://doi.org/10.1016/s1474-4422(14)70218-2
Acknowledgments 6. Kachooei-Mohaghegh-Yaghoobi L, Rezaei-Rad F,

None. Sadeghniiat-Haghighi K, et al., 2020, The impact of the
HLA DQB1 gene and amino acids on the development of
Funding narcolepsy. Int J Neurosci, 132(7): 706–713.
https://doi.org/10.1080/00207454.2020.1835903
No funding was received in drafting this manuscript.
7. Bourgin P, Zeitzer JM, Mignot E, 2008, CSF hypocretin-1
Conflict of interest assessment in sleep and neurological disorders. Lancet
Neurol, 7(7): 649–662.
The authors have no conflict of interest to declare.
https://doi.org/10.1016/s1474-4422(08)70140-6
Author contributions 8. Martinez-Orozco FJ, Vicario JL, Villalibre-Valderrey I,

Data curation: Chaofan Geng et al., 2014, Narcolepsy with cataplexy and comorbid
Writing – original draft: Chaofan Geng, Zhenzhen Yang immunopathological diseases. J Sleep Res, 23(4): 414–419.
Writing – review & editing: Hongju Zhang https://doi.org/10.1111/jsr.12143
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https://doi.org/10.1016/j.sleep.2013.03.015
A written informed consent was obtained from the patient
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