Page 92 - GPD-2-3

Gene & Protein in Disease MIS-A with LETM after SARS-CoV-2 vaccine

wanes with majority of population having access to pandemic. Lancet, 395(10237): 1607–1608.
vaccines, vaccine-related adverse events are gradually https://doi.org/10.1016/S0140‑6736(20)31094‑1
emerging. Various reports of Guillain-Barre syndrome,
transverse myelitis, encephalitis, meningitis, Bell’s palsy, 2. Verdoni L, Mazza A, Gervasoni A, et al., 2020, An outbreak
and hemorrhagic strokes, CNS demyelination, myasthenic of severe Kawasaki-like disease at the Italian epicentre of
the SARS‑CoV‑2 epidemic: An observational cohort study.
syndromes, and MIS-A have emerged after SARS-CoV-2 Lancet, 395(10239): 1771–1778.
vaccination [11-14] . Our case report provides insights to
aid further investigation on this topic. Based on the https://doi.org/10.1016/S0140‑6736(20)31103‑X
case presented here, the onset of MIS-A with LETM 3. Morris SB, Schwartz NG, Patel P, et al., 2020, Case series of
occurs following SARS-CoV-2 vaccination. However, multisystem inflammatory syndrome in adults associated
the potential association between vaccination and these with SARS-CoV-2 infection-United Kingdom and United
symptoms should not dissuade us from vaccination, which States, March-August 2020. MMWR Morb Mortal Wkly Rep,
regardless has proven to be a protective approach against 69(40): 1450–1456.
SARS-CoV-2 infection. https://doi.org/10.15585/mmwr.mm6940e1

Acknowledgments 4. Das S, Kar SS, Samanta S, et al., 2022, Immunogenic
and reactogenic efficacy of Covaxin and Covishield:
None. A comparative review. Immunol Res, 70(3): 289–315.
https://doi.org/10.1007/s12026‑022‑09265‑0
Funding
5. Garg RK, Paliwal V, Malhotra HS, et al., 2023, Spectrum
None. of serious neurological and psychiatric adverse events in
Indian COVID‑19 vaccine recipients: A systematic review
Conflict of interest of case reports and case series. Neurol India, 71: 209–227.
The authors declare they have no competing interests. https://doi.org/10.4103/0028‑3886.375420
Author contributions 6. Uwaydah AK, Hassan NM, Abu Ghoush MS, et al., 2021,
Adult multisystem inflammatory syndrome in a patient who
Conceptualization: Anirban Gupta, Sudheer Pandey recovered from COVID-19 postvaccination. BMJ Case Rep,
Investigation: All authors 14(4): e242060.
Writing – original draft: Anirban Gupta, Sudheer Pandey https://doi.org/10.1136/bcr‑2021‑242060
Writing – review & editing: Anirban Gupta
7. Salzman MB, Huang CW, O’Brien CM, et al., 2021,
Ethics approval and consent to participate Multisystem inflammatory syndrome after SARS-CoV-2
infection and COVID-19 vaccination. Emerg Infect Dis,
Ethical approval was waived due to retrospective nature of 27(7): 1944–1948.
report. Informed consent was taken from of patients. https://doi.org/10.3201/eid2707.210594
Consent for publication 8. Gao JJ, Tseng HP, Lin CL, et al., 2021, Acute transverse
myelitis following Covid-19 vaccination. Vaccines (Basel),
Consent for publication was taken from the patient verbally 9(9): 1008.
and in writing.
https://doi.org/10.3390/vaccines9091008
Availability of data 9. Pagenkopf C, Südmeyer M, 2021, A case of longitudinally
Not applicable. extensive transverse myelitis following vaccination against
Covid-19. J Neuroimmunol, 358: 577606.
Further disclosure https://doi.org/10.1016/j.jneuroim.2021.577606
This case was presented in Indian Academy of Neurology 10. Pourmoghaddas Z, Sadeghizadeh A, Tara SZ, et al., 2021,
Conference in New Delhi in 2022 and the paper has been Longitudinally extensive transverse myelitis as a sign of
uploaded to Research Square (https://doi.org/10.21203/ multisystem inflammatory syndrome following COVID-19
rs.3.rs-1564946/v1). infection: A pediatric case report. J Neuroimmunol,
360: 577704.
References https://doi.org/10.1016/j.jneuroim.2021.577704

1. Riphagen S, Gomez X, Gonzalez-Martinez C, et al., 2020, 11. Ismail II, Salama S, 2022, A systematic review of cases of
Hyperinflammatory shock in children during COVID-19 CNS demyelination following COVID-19 vaccination.

Volume 2 Issue 3 (2023) 5 https://doi.org/10.36922/gpd.1320