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Gene & Protein in Disease The role of metalloproteinases in atherosclerosis

There are only four members of TIMP family: currently, References
there is no evidence of specific roles for TIMP-1, TIMP-2, 1. Costa D, Ielapi N, Minici R, et al. Metalloproteinases between
and TIMP-4 in atherosclerosis, whereas TIMP-3 was found history, health, disease, and the complex dimension of social
to play protective roles in positively influencing plaque determinants of health. J Vasc Dis. 2023;2(3):282-298.
stability and effectively counteracting metalloproteinase
activity. 3 doi: 10.3390/jvd2030021
Over time, several synthetic MMP inhibitors have 2. Costa D, Scalise E, Ielapi N, Bracale UM, Andreucci M,
been identified with the aim to prevent or to treat clinical Serra R. Metalloproteinases as biomarkers and sociomarkers
in human health and disease. Biomolecules. 2024;14:96.
manifestations related to atherosclerosis, but the results
obtained have been far from encouraging. Despite that, doi: 10.3390/biom14010096
MMPs hold promise as potential biomarkers for several 3. Johnson JL. Metalloproteinases in atherosclerosis. Eur J
diseases related to atherosclerosis such as CAD, CAS, Pharmacol. 2017;816:93-106.
peripheral artery disease, and aneurysms.
doi: 10.1016/j.ejphar.2017.09.007
Novel research unraveling the genomics, transcriptomics, 4. Frostegård J. Immunity, atherosclerosis and cardiovascular
and proteomics of metalloproteinases is warranted to clarify disease. BMC Med. 2013;11:117.
their roles in disease development and progression so that
safe and effective strategies can be formulated to prevent doi: 10.1186/1741-7015-11-117
and target clinical events associated with atherosclerotic 5. Bao CH, Zhang C, Wang XM, Pan YB. Concurrent acute
disease. myocardial infarction and acute ischemic stroke: Case
reports and literature review. Front Cardiovasc Med.
Conflict of interest 2022;9:1012345.
The author declares no conflicts of interest. doi: 10.3389/fcvm.2022.1012345

Volume 3 Issue 1 (2024) 2 https://doi.org/10.36922/gpd.2776