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Global Translational Medicine Folic acid for stroke prevention

Homocysteine and Vascular Disease. Heidelberg: Springer doi: 10.1161/strokeaha.108.540781
Netherlands; 2000. p. 271-289.
21. Blom HJ, Smulders Y. Overview of homocysteine and folate
10. McRae MP. High-dose folic acid supplementation effects metabolism. With special references to cardiovascular
on endothelial function and blood pressure in hypertensive disease and neural tube defects. J Inherit Metab Dis.
patients: A meta-analysis of randomized controlled clinical 2011;34(1):75-81.
trials. J Chiropr Med. 2009;8(1):15-24.
doi: 10.1007/s10545-010-9177-4
doi: 10.1016/j.jcm.2008.09.001
22. Pietrzik K, Bailey L, Shane B. Folic acid and L-5-
11. Antoniades C, Shirodaria C, Warrick N, et al. methyltetrahydrofolate: Comparison of clinical
5-Methyltetrahydrofolate rapidly improves endothelial pharmacokinetics and pharmacodynamics. Clin
function and decreases superoxide production in human Pharmacokinet. 2010;49(8):535-548.
vessels: Effects on vascular tetrahydrobiopterin availability doi: 10.2165/11532990-000000000-00000
and endothelial nitric oxide synthase coupling. Circulation.
2006;114(11):1193-1201. 23. Auton A, Brooks LD, Durbin RM, et al. A global reference
for human genetic variation. Nature. 2015;526(7571):68-74.
doi: 10.1161/CIRCULATIONAHA.106.612325
doi: 10.1038/nature15393
12. Carboni L. Active folate versus folic acid: The role of
5-MTHF (Methylfolate) in human health. Integr Med 24. Graydon JS, Claudio K, Baker S, et al. Ethnogeographic
(Encinitas). 2022;21(3):36-41. prevalence and implications of the 677C>T and 1298A>C
MTHFR polymorphisms in US primary care populations.
13. Yang Q, Botto LD, Erickson JD, et al. Improvement in stroke Biomark Med. 2019;13(8):649-661.
mortality in Canada and the United States, 1990 to 2002.
Circulation. 2006;113(10):1335-1343. doi: 10.2217/bmm-2018-0392
doi: 10.1161/circulationaha.105.570846 25. Bennett DA, Parish S, Millwood IY, et al. MTHFR and
risk of stroke and heart disease in a low-folate population:
14. Tian T, Yang KQ, Cui JG, Zhou LL, Zhou XL. Folic acid A prospective study of 156 000 Chinese adults. Int J
supplementation for stroke prevention in patients with Epidemiol. 2023;52:1862-1869.
cardiovascular disease. Am J Med Sci. 2017;354(4):379-387.
doi: 10.1093/ije/dyad147
doi: 10.1016/j.amjms.2017.05.020
26. Oxford Population Health. Folic Acid Supplements
15. Hsu CY, Chiu SW, Hong KS, et al. Folic acid in stroke May Reduce the Risk of Stroke in People with Genetic
prevention in countries without mandatory folic acid food Predisposition. Oxford. Available from: https://www.
fortification: A meta-analysis of randomized controlled ndph.ox.ac.uk/news/folic-acid-supplements-may-
trials. J Stroke. 2018;20:99-109.
reduce-the-risk-of-stroke-in-people-with-genetic-
16. Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB. Folic acid predisposition#:~:text=folic%20acid%20also%20lowers%20
supplementation and the risk of cardiovascular diseases: blood,such%20as%20bread%20and%20cereals [Last
A meta-analysis of randomized controlled trials. J Am Heart accessed on 2023 Dec 07].
Assoc. 2016;5(8):e003768.
27. Huo Y, Li J, Qin X, et al. Efficacy of folic acid therapy
doi: 10.1161/jaha.116.003768 in primary prevention of stroke among adults with
hypertension in China: The CSPPT randomized clinical
17. Lee M, Hong KS, Chang SC, Saver JL. Efficacy of
homocysteine-lowering therapy with folic acid in stroke trial. JAMA. 2015;313(13):1325-1335.
prevention: A meta-analysis. Stroke. 2010;41(6):1205-1212. doi: 10.1001/jama.2015.2274
doi: 10.1161/strokeaha.109.573410 28. Shirodaria C, Antoniades C, Lee J, et al. Global improvement
of vascular function and redox state with low-dose folic acid:
18. Cohen E, Margalit I, Shochat T, Goldberg E, Krause I. Sex
differences in folate levels: A cross sectional study of a large Implications for folate therapy in patients with coronary
cohort from Israel. Isr Med Assoc J. 2021;23(1):17-22. artery disease. Circulation. 2007;115(17):2262-2270.
doi: 10.1161/circulationaha.106.679084
19. Ray JG, Vermeulen MJ, Boss SC, Cole DEC. Declining rate
of folate insufficiency among adults following increased 29. Sauer J, Mason JB, Choi SW. Too much folate-A risk factor
folic acid food fortification in Canada. Can J Public Health. for cancer and cardiovascular disease? Curr Opin Clin Nutr
2002;93(4):249-253. Metab Care. 2009;12(1):30-36.
doi: 10.1007/bf03405010 doi: 10.1097/MCO.0b013e32831cec62
20. Appelros P, Stegmayr B, Terént A. Sex differences in stroke 30. Cheng Y, Liu S, Chen D, et al. Association between
epidemiology: A systematic review. Stroke. 2009;40(4): serum 5-methyltetrahydrofolate and homocysteine in
1082-1090. Chinese hypertensive participants with different MTHFR

Volume 3 Issue 2 (2024) 5 doi: 10.36922/gtm.2509