Page 9 - IJB-10-6

International

Journal of Bioprinting

REVIEW ARTICLE
3D bioprinting technologies for the

enhancement and application of functional
lung organoid models

Jimin Jang 1† id , Jooyoung Lee 2† id , Sangryul Cha 1 id , Minkyoung Lee 2 id ,
Hyungseok Lee * , and Se-Ran Yang * id
1
2,3
id
1 Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kangwon National
University, Chuncheon, Gangwon State, Republic of Korea
2 Department of Smart Health Science and Technology, College of Engineering Kangwon National
University, Chuncheon, Gangwon State, Republic of Korea
3
Department of Mechanical and Biomedical, Mechatronics Engineering, College of Engineering,
Kangwon National University, Chuncheon, Gangwon State, Republic of Korea
(This article belongs to the Special Issue: The latest advancements in bioprinting technology)

Abstract

Respiratory diseases, ranging from minor infections to serious chronic diseases and
malignancies, negatively affect the respiratory system and are influenced by various
environmental factors such as air pollution, occupational hazards, and tobacco
smoke, as well as lifestyle, genetic causes, and infectious agents. The prevalence
† These authors contributed equally and severity of respiratory diseases require the development of advanced models
to this work. to better understand their pathophysiology and develop effective treatments. In
*Corresponding authors: this context, 3D bioprinting technology emerges as an innovative tool to create
Hyungseok Lee functional lung organoid models. The use of induced pluripotent stem cells and
(ahl@kangwon.ac.kr) extracellular matrix in bioprinting enables the development of organoids that
Se-Ran Yang closely mimic human lung tissue. Bioprinting-based organoids can better replicate
(seran@kangwon.ac.kr)
the dynamic environment of the human lung, facilitating more accurate disease
Citation: Jang J, Lee J, Cha S, modeling and drug testing. In this review, we highlight the potential of bioprinted
Lee M, Lee H, Yang S. 3D lung organoids in understanding the mechanisms of chronic respiratory diseases,
Bioprinting technologies for the
enhancement and application of testing the efficacy and safety of new drugs, and exploring regenerative medicine
functional lung organoid models. approaches. The integration of advanced bioprinting and organoid technologies is a
Int J Bioprint. 2024;10(6):4092. promising field in respiratory disease research and treatment, offering new hope for
doi: 10.36922/ijb.4092
patients suffering from lung diseases.
Received: June 30, 2024
Revised: August 14, 2024
Accepted: August 14, 2024 Keywords: Alveolar organoid; Chronic respiratory disease; Bioprinting;
Published Online: August 16, 2024
Extracellular matrix; Induced pluripotent stem cells
Copyright: © 2024 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, 1. Introduction
and reproduction in any medium,
provided the original work is 1.1. Traditional animal models in pulmonary disease research and limitations
properly cited. Respiratory diseases constitute a significant part of the global health challenges,
1
Publisher’s Note: AccScience encompassing a wide range of conditions that adversely impact the respiratory system.
Publishing remains neutral with These conditions vary from mild infections to severe chronic disorders and malignancies,
regard to jurisdictional claims in
published maps and institutional which significantly affect the quality of life and, in many instances, lead to considerable
affiliations. morbidity and mortality. 2

Volume 10 Issue 6 (2024) 1 doi: 10.36922/ijb.4092