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INNOSC Theranostics and
Pharmacological Sciences Therapeutic value of terpenes

119. Eddin LB, Jha NK, Meeran MN, Kesari KK, Beiram R, Med Chem. 2020;20(13):1530-1537.
Ojha S. Neuroprotective potential of limonene and limonene doi: 10.2174/1871520620666200227093216
containing natural products. Molecules. 2021;26(15):4535.
130. Jia SS, Xi GP, Zhang M, et al. Induction of apoptosis by
doi: 10.3390/molecules26154535
D-limonene is mediated by inactivation of Akt in LS174T
120. Price E. Researchers see Promising Results Using Cannabis human colon cancer cells. Oncol Rep. 2013;29(1):349-354.
Terpenes to Treat Covid-19. Forbes. Available from: https://
www.forbes.com/sites/emilyprice/2020/08/09/researchers- doi: 10.3892/or.2012.2093
see-promising-results-using-cannabis-terpenes-to-treat- 131. Iwasaki K, Zheng YW, Murata S, et al. Anticancer
covid-19/?sh=4d021d574071 [Last accessed on 2023 Feb 07]. effect of linalool via cancer-specific hydroxyl radical
generation in human colon cancer. World J Gastroenterol.
121. Keyser Z. Israeli Study finds Efficacy in Using Cannabis
Terpenes to Treat COVID-19. The Jerusalem Post. Available 2016;22(44):9765-9774.
from: https://www.jpost.com/health-science/israeli- doi: 10.3748/wjg.v22.i44.9765
study-finds-efficacy-in-using-cannabis-terpenes-to-treat- 132. Sampath S, Subramani S, Janardhanam S, Subramani P,
covid-19-638198 [Last accessed on 2023 Feb 07]. Yuvaraj A, Chellan R. Bioactive compound 1, 8-Cineole
122. Tomko AM, Whynot EG, O’Leary LF, Dupré DJ. Anti- selectively induces G2/M arrest in A431 cells through the
cancer potential of cannabis terpenes in a taxol-resistant upregulation of the p53 signaling pathway and molecular
model of breast cancer. Can J Physiol Pharmacol. docking studies. Phytomedicine. 2018;46:57-68.
2022;100(8):806-817. doi: 10.1016/j.phymed.2018.04.007
doi: 10.1139/cjpp-2021-0792 133. Meng X, Dong X, Wang W, et al. Natural borneol enhances
123. Miller JA, Pappan K, Thompson PA, et al. Plasma paclitaxel‐induced apoptosis of ESCC cells by inactivation
metabolomic profiles of breast cancer patients after short- of the PI3K/AKT. J Food Sci. 2018;83(5):1436-1443.
term limonene intervention. Cancer Prev Res (Phila). doi: 10.1111/1750-3841.14143
2015;8(1):86-93.
134. Murata S, Shiragami R, Kosugi C, et al. Antitumor
doi: 10.1158/1940-6207.CAPR-14-0100
effect of 1, 8-cineole against colon cancer. Oncol
124. Ye Z, Liang Z, Mi Q, Guo Y. Limonene terpenoid obstructs Rep. 2013;30(6):2647-2652.
human bladder cancer cell (T24 cell line) growth by doi: 10.3892/or.2013.2763
inducing cellular apoptosis, caspase activation, G2/M
phase cell cycle arrest and stops cancer metastasis. J BUON. 135. Rigo A, Vinante F. The antineoplastic agent α-bisabolol
2020;25:280-285. promotes cell death by inducing pores in mitochondria and
lysosomes. Apoptosis. 2016;21:917-927.
125. Hou J, Zhang Y, Zhu Y, et al. α-Pinene induces apoptotic
cell death via caspase activation in human ovarian cancer doi: 10.1007/s10495-016-1257-y
cells. Med Sci Monit. 2019;25:6631-6638.
136. Cavalieri E, Mariotto S, Fabrizi C, et al. α-Bisabolol,
doi: 10.12659/MSM.916419 a nontoxic natural compound, strongly induces
apoptosis in glioma cells. Biochem Biophys Res Commun.
126. Zhao Y, Chen R, Wang Y, Yang Y. α-Pinene inhibits human 2004;315(3):589-594.
prostate cancer growth in a mouse xenograft model.
Chemotherapy. 2018;63(1):1-7. doi: 10.1016/j.bbrc.2004.01.088
doi: 10.1159/000479863 137. Rigo A, Ferrarini I, Bonalumi A, et al. Efficient lysis of
B-chronic lymphocytic leukemia cells by the plant-derived
127. Chen H, Yuan J, Hao J, et al. α-Humulene inhibits sesquiterpene alcohol α-bisabolol, a dual proapoptotic and
hepatocellular carcinoma cell proliferation and induces
apoptosis through the inhibition of Akt signaling. Food antiautophagic agent. Oncotarget. 2018;9(40):25877-25890.
Chem Toxicol. 2019;134:110830. doi: 10.18632/oncotarget.25398
doi: 10.1016/j.fct.2019.110830 138. Chang MY, Shieh DE, Chen CC, Yeh CS, Dong HP. Linalool
induces cell cycle arrest and apoptosis in leukemia cells
128. Sobral MV, Xavier AL, Lima TC, de Sousa DP. Antitumor
activity of monoterpenes found in essential oils. and cervical cancer cells through CDKIs. Int J Mol Sci.
ScientificWorldJournal. 2014;2014:953451. 2015;16(12):28169-28179.
doi: 10.3390/ijms161226089
doi: 10.1155/2014/953451
139. Rao V, Menezes A, Viana G. Effect of myrcene on nociception
129. Arul S, Rajagopalan H, Ravi J, Dayalan H. Beta-
caryophyllene suppresses ovarian cancer proliferation by in mice. J Pharm Pharmacol. 1990;42(12):877-878.
inducing cell cycle arrest and apoptosis. AntiCancer Agents doi: 10.1111/j.2042-7158.1990.tb07046.x

Volume 7 Issue 3 (2024) 19 doi: 10.36922/itps.0332