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INNOSC Theranostics and
            Pharmacological Sciences                            Knowledge, perception, and practices of ecopharmacovigilance




            Table 3. Practices related to EPV among medical students   antimicrobial residues. The finding for this aspect was not
            (n=300)                                            statistically significant (p=0.674).
            Survey questions                     Responses,    4. Discussion
                                                 number (%)
            1.  How often do you check the expiry date of your   The WHO defines pharmacovigilance as “the science
              medications?                                     and activities relating to the detection, assessment,
               Often                              221 (73.7)   understanding, and prevention of adverse effects or
               Sometimes                           57 (19)     any other possible drug-related problems.” Due to its
               Rarely                              20 (6.7)    importance in reducing the harmful effects associated with
               Never                               2 (0.7)     pharmaceutical residues, EPV has drawn significant interest
            2.  How often do you take your medications according   from the research community as a significant application of
              to the advice of your doctor or pharmacist?      pharmacovigilance in environmental science. 3,8,11  Globally,
               Often                              220 (73.3)   EPV  should  be promoted, particularly in  developing
               Sometimes                           66 (22)     nations with dense populations and often insufficient
               Rarely                              13 (4.3)    sewage treatment systems. The successful adoption of
               Never                               1 (0.3)     EPV by medical students and their subsequent behavioral
            3.  When multiple medications are prescribed to    changes depends on their comprehensive understanding,
              you or your family members, do you use only the   knowledge,  and  positive  perception  of  the  issue,  which
              prescribed medications?                          could improve the efficacy of EPV implementation.
               Often                              157 (52.3)
               Sometimes                          119 (39.7)     To the best of our knowledge, this is the first study in
               Rarely                              18 (6)      Bangladesh to assess medical students’ understanding,
               Never                                6 (2)      perceptions, and practices related to EPV and environmental
            4.  How often do you practice self-medication for   pharmaceutical contamination. Only 27% of the participants
              minor illness, such as fever or headaches?       were familiar with EPV, highlighting the urgent need for
               Often                              145 (48.3)   comprehensive education on the subject for medical students.
               Sometimes                          111 (37)     A  separate study conducted in Bangladesh revealed that
               Rarely                              13 (10)     pharmacy students possessed limited knowledge regarding
               Never                               14 (4.7)    proper medication disposal methods. Approximately 58%
            5.  How often do you buy OTC medications that      of  students disposed  of  their  liquid medications  in  sinks
              require a valid prescription?                    or toilets, where they ultimately reached the wastewater
                                                                             51
               Often                              89 (29.7)    treatment system.  The respondents’ knowledge of the
               Sometimes                          132 (44)     ecological hazards posed by drug residues and the increased
               Rarely                             68 (22.7)    antibiotic resistance in bacterial communities, potentially
               Never                               11 (3.7)    caused by antimicrobial residues in the environment. This
            6.  What factors limit the use of medications prescribed   includes the destruction of many Asian Gyps vultures due to
              to your family members?                          veterinary diclofenac residues, the feminization of male fish,
               Forgetfulness                      129 (43)     and the sterility of frogs, which may result from hormonal
               Medication ineffectiveness          15 (5)      compounds  in water.  The accuracy rates  for  these issues
               Medications adverse effects        32 (10.7)    were77.7%, 68%, and 60%, respectively. These potential
               Improvement of health condition    124 (41.3)   environmental hazards associated with antibacterials
            7.  What do you do with any unused medications     and hormonal compounds align with the usual impacts
              remaining at your home or hostel?                of  pharmaceuticals,  such  as  antibiotic-induced  bacterial
               Throw away in household garbage    59 (19.7)    resistance and the endocrine-disrupting effects of hormones.
               Keep at home until it gets expired  218 (72.7)  Gyps vulture populations in the Indian subcontinent were
               Burn them along with garbage        1 (0.3)     largely destroyed due to diclofenac. Approximately 97.3%
               Return it to pharmacy shop          22 (7.3)    of participants expressed a desire to learn more about
            8.  Have you ever educated your friends or family   take-back programs, safe disposal techniques, potential
              members about the safe and proper disposal of    environmental pharmaceutical residues, and the handling
              medicines?                                       of unwanted medications, indicating an active interest in
               Yes                                68 (22.7)    environmental protection. The study’s most promising
               No                                 232 (70.3)   result is that 99% of students expressed interest in using eco-
            Abbreviations: EPV: Ecopharmacovigilance; OTC: Over-the-counter.  friendly methods for disposing of unwanted medications in


            Volume 8 Issue 3 (2025)                         64                               doi: 10.36922/itps.7678
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