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Journal of Clinical and
Basic Psychosomatics Microbiota in psychosomatic disorders

neuroinflammatory conditions. This diet shifts the enhance gut–brain communication, are therefore critical
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gut microbiota by promoting the growth of species in managing these disorders.
involved in fat metabolism while reducing the abundance Personalized probiotics and pre-biotics offer a promising
of carbohydrate-fermenting bacteria. Personalized therapeutic avenue for psychosomatic conditions by
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versions of the ketogenic diet can be tailored to enhance targeting specific microbial deficiencies and supporting
its efficacy for specific individuals based on their gut gut health. Unlike generalized probiotic formulations,
microbiota profile and metabolic responses. personalized probiotics are tailored to the unique microbial

Fecal matter transplant is a novel approach with the composition of each individual, allowing for the selection
potential to be tailored for personalized treatments. While of bacterial strains that can correct specific imbalances.
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FMT has been primarily used to treat C. difficile infections, In addition to microbial and dietary interventions,
emerging evidence suggests it may also be effective in psychosomatic conditions can also benefit from
treating psychiatric conditions, such as depression and personalized lifestyle and behavioral strategies. Stress
anxiety, and GI disorders, such as IBS. In the context of reduction techniques, such as mindfulness, CBT, and
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personalized medicine, FMT could be optimized by selecting other psychological interventions, have been shown
donor microbiota that closely matches the specific needs of to modulate the gut–brain axis by reducing cortisol
the recipient. For example, a recipient with low microbial levels, improving gut motility, and enhancing microbial
diversity may benefit from an FMT donor with a high diversity. For individuals with stress-related gut disorders,
level of microbial richness and beneficial species, such as integrating these personalized behavioral approaches with
Faecalibacterium and Akkermansia. Personalized FMT microbiota-targeted treatments can yield better outcomes
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also involves screening for specific bacterial strains that are by addressing both the psychological triggers and the
lacking or imbalanced in the recipient’s microbiota. The physical symptoms of their condition.
use of microbiota from carefully screened donors or even
engineered microbial communities could ensure that the Personalized medicine in the context of psychosomatic
intervention is tailored to the unique dysbiosis of the patient. conditions offers a comprehensive and individualized
approach to treatment, targeting both the mental and
5. Conclusion physical aspects of these disorders. By integrating
microbiome-based diagnostics, personalized probiotics
Personalized medicine offers a groundbreaking approach
to the management of psychosomatic conditions by and pre-biotics, tailored dietary interventions, and
behavioral therapies, clinicians can more effectively manage
recognizing and targeting the convoluted relationship conditions such as IBS, IBD, depression, and anxiety. As
between gut microbiota and mental health. Psychosomatic our understanding of the gut–brain axis continues to
disorders, such as depression, anxiety, IBS, and IBD, involve evolve, personalized medicine promises to transform the
complex interactions between psychological factors and
physical symptoms, mediated largely by the gut–brain treatment landscape for psychosomatic disorders, offering
axis. Personalized medicine seeks to tailor interventions new avenues for improving patient outcomes through a
holistic, tailored approach.
based on an individual’s unique microbial composition,
psychological profile, and physiological responses for Acknowledgments
more effective treatments that address both the mental and
physical dimensions of these conditions. None.
Advances in microbiome-based diagnostics and Funding
the identification of specific microbial biomarkers are
central to this personalized approach. With the use of None.
high-throughput sequencing and computational models, Conflict of interest
clinicians can assess an individual’s gut microbiota
composition and detect microbial imbalances or dysbiosis The authors declare they have no competing interests.
associated with psychosomatic conditions. For instance, low Author contributions
microbial diversity and the depletion of beneficial bacteria,
such as Bifidobacterium and Faecalibacterium, have been Conceptualization: Alberto K. De la Herrán-Arita
linked to both GI and mental health symptoms, including Visualization: Alejandro Camacho-Zamora, Alberto K. De
increased gut permeability, systemic inflammation, la Herrán-Arita
and altered neurotransmitter production. Personalized Writing – original draft: Alejandro Camacho-Zamora,
interventions, designed to restore microbial balance and Ángel R. Rábago-Monzón, Josué

Volume 3 Issue 3 (2025) 37 doi: 10.36922/JCBP025040008