Page 13 - JCBP-3-4

Journal of Clinical and
Basic Psychosomatics Neuroimaging of bipolar disorder and self-stigma

4. Summary and outlook Consent for publication

In summary, numerous correlations have been found in Not applicable.
existing research between the brain regions involved in
emotion regulation (such as the PFC, ACC, and amygdala) Availability of data
and the default mode network, as well as the emergence A literature search for this review was conducted using
of SS. Moreover, neurometabolites such as NAA and Gln the topic words “bipolar disorder” and “self-stigma” in the
undergo changes in both BD and SS. At present, both PubMed and Embase databases. The search was limited to
local and international scholars attach great importance studies published within the past 10 years.
to SS in patients with mental disorders. However,
imaging studies on SS are mostly cross-sectional, and the References
neuropathophysiological mechanisms of SS in BD remain 1. Rosenblat JD, McIntyre RS. Treatment of mixed features in
unclear. In the future, we can conduct further research on bipolar disorder. CNS Spectr. 2017;22(2):141-146.
the neuroimaging of BD and SS, and increase the number of doi: 10.1017/S1092852916000547
prospective studies. This will enable us to better understand
the changes in the brain regions with functional disorders, 2. Miller TH. Bipolar disorder. Prim Care. 2016;43(2):269-284.
neural circuits, and neurometabolites. By analyzing doi: 10.1016/j.pop.2016.02.003
these changes, we can explain the symptoms of patients, 3. Plans L, Barrot C, Nieto E, et al. Association between
search for intervention measures for SS, and enhance the completed suicide and bipolar disorder: A systematic review
awareness of clinical workers regarding SS. This is of great of the literature. J Affect Disord. 2019;24(2):111-122.
significance for the early identification and intervention of doi: 10.1016/j.jad.2018.08.054
BD patients with SS.
4. Carpiniello B, Pinna F. The reciprocal relationship between
Acknowledgments suicidality and stigma. Front Psychiatry. 2017;8:35.
None. doi: 10.3389/fpsyt.2017.00035
5. Schaffer A, Isometsa ET, Tondo L, et al. International society
Funding for bipolar disorders task force on suicide: Meta-analyses and
Natural Science Foundation of Xinjiang Uygur meta-regression of correlates of suicide attempts and suicide
Autonomous Region (2022D01C606); Tianshan Innovative deaths in bipolar disorder. Bipolar Disord. 2015;17(1):1-16.
Team Program (2022D14011). doi: 10.1111/bdi.12271
Conflict of interest 6. Leboyer M, Kupfer DJ. Bipolar disorder: New perspectives
in health care and prevention. J Clin Psychiatry.
Shaohong Zou is an Editorial Board Member of this 2010;71(12):1689-1695.
journal and Guest Editor of this special issue but was doi: 10.4088/JCP.10m06347yel
not in any way involved in the editorial and peer- 7. Fernandez D, Grandon P, Lopez-Angulo Y, Vladimir-
review process conducted for this paper, directly or Vielma A, Peñate W, Díaz-Pérez G. Internalized stigma and
indirectly. Separately, other authors declared that they self-stigma in people diagnosed with a mental disorder.
have no known competing financial interests or personal One concept or two? A scoping review. Int J Soc Psychiatry.
relationships that could have influenced the work 2023;69(8):1869-1881.
reported in this paper.
doi: 10.1177/00207640231196749
Author contributions 8. Dubreucq J, Plasse J, Gabayet F, et al. Self-stigma in serious
mental illness and autism spectrum disorder: Results from
Conceptualization: Longyuan Zhang, Shaohong Zou, the REHABase national psychiatric rehabilitation cohort.
Xiaoxiao Tang Eur Psychiatry. 2020;63(1):e13.
Writing – original draft: Longyuan Zhang, Yingshuai Li, doi: 10.1192/j.eurpsy.2019.12
Xiaoxiao Tang
Writing – review & editing: Chengji Wang, Shaohong Zou, 9. Favre S, Richard-Lepouriel H. Self-stigma and bipolar
Longyuan Zhang disorder: A systematic review and best-evidence synthesis.
J Affect Disord. 2023;33(5):273-288.
Ethics approval and consent to participate doi: 10.1016/j.jad.2023.05.041
Not applicable. 10. Brohan E, Gauci D, Sartorius N, Thornicroft G. Self-stigma,

Volume 3 Issue 4 (2025) 7 doi: 10.36922/jcbp.8413