Page 38 - TD-4-3
P. 38

Tumor Discovery                                                 Immunomodulatory effects of CDK4/6 inhibitors



               positive breast cancer. Histopathology. 2024;87:3-17.  80.  Wu S, Xu J, Ma Y, Liang G, Wang J, Sun T. Advances
                                                                  in the mechanism of CDK4/6 inhibitor resistance
               doi: 10.1111/his.15395
                                                                  in  HR+/HER2-  breast  cancer.  Ther Adv Med Oncol.
            72.  Finn RS, Boer K, Bondarenko I,  et al. Overall survival   2024;16:17588359241282499.
               results from the randomized phase 2 study of palbociclib
               in combination with letrozole versus letrozole alone      doi: 10.1177/17588359241282499
               for first-line treatment of ER+/HER2-  advanced breast   81.  Morrison L, Loibl S, Turner NC. The CDK4/6 inhibitor
               cancer (PALOMA-1, TRIO-18).  Breast Cancer Res Treat.   revolution - a game-changing era for breast cancer treatment.
               2020;183(2):419-428.                               Nat Rev Clin Oncol. 2024;21(2):89-105.
               doi: 10.1007/s10549-020-05755-7                    doi: 10.1038/s41571-023-00840-4
            73.  Im SA, Mukai H, Park IH, et al. Palbociclib plus letrozole   82.  Klein ME, Kovatcheva M, Davis LE, Tap WD, Koff A.
               as first-line therapy in postmenopausal Asian women   CDK4/6 inhibitors: The mechanism of action may not be as
               with metastatic breast cancer: Results from the phase III,   simple as once thought. Cancer Cell. 2018;34(1):9-20.
               randomized PALOMA-2 study. J Glob Oncol. 2019;5:1-19.
                                                                  doi: 10.1016/j.ccell.2018.03.023
               doi: 10.1200/JGO.18.00173
                                                               83.  Teh JLF, Aplin AE. Arrested developments: CDK4/6
            74.  Cristofanilli M, Rugo HS, Im SA,  et  al. Overall survival   Inhibitor resistance and alterations in the tumor immune
               with palbociclib and fulvestrant in women with HR+/  microenvironment. Clin Cancer Res. 2019;25(3):921-927.
               HER2- ABC: Updated exploratory analyses of PALOMA-3,      doi: 10.1158/1078-0432.CCR-18-1967
               a double-blind, phase III randomized study. Clin Cancer Res.
               2022;28(16):3433-3442.                          84.  De Angelis C, Fu X, Cataldo ML, et al. Activation of the IFN
                                                                  signaling pathway is associated with resistance to CDK4/6
               doi: 10.1158/1078-0432.CCR-22-0305
                                                                  inhibitors and immune checkpoint activation in ER-positive
            75.  Jhaveri K, O’Shaughnessy J, Fasching PA, et al. Matching-  breast cancer. Clin Cancer Res. 2021;27(17):4870-4882.
               adjusted indirect comparison of PFS and OS comparing      doi: 10.1158/1078-0432.CCR-19-4191
               ribociclib plus letrozole versus palbociclib plus letrozole as
               first-line treatment of HR+/HER2- advanced breast cancer.   85.  Sammons S, Moore H, Cushman J, Hamilton E. Efficacy,
               Ther Adv Med Oncol. 2023;15:103580.                safety and toxicity management of adjuvant abemaciclib in
                                                                  early stage HR+/HER2- high-risk breast cancer. Expert Rev
               doi: 10.1177/17588359231216095
                                                                  Anticancer Ther. 2022;22(8):805-814.
            76.  Slamon DJ,  Neven P, Chia S,  et al. Phase  III randomized      doi: 10.1080/14737140.2022.2093719
               study of ribociclib and fulvestrant in hormone receptor-
               positive, human epidermal growth factor receptor   86.  Nabieva  N,  Fasching  PA.  CDK4/6  inhibitors-overcoming
               2-negative advanced breast cancer: MONALEESA-3. J Clin   endocrine  resistance  is  the  standard  in  patients  with
               Oncol. 2018;36(24):2465-2472.                      hormone  receptor-positive breast  cancer.  Cancers(Basel).
                                                                  2023;15(6):1763.
               doi: 10.1200/JCO.2018.78.9909
                                                                  doi: 10.3390/cancers15061763
            77.  Lu YS, Im SA, Colleoni M, et al. Updated overall survival
               of ribociclib  plus endocrine  therapy versus  endocrine   87.  Zhao S, Zhang H, Yang N, Yang J. A narrative review about
               therapy alone in pre-  and perimenopausal patients with   CDK4/6 inhibitors in the setting of drug resistance: Updates
               HR+/HER2-  advanced breast cancer in MONALEESA-7:   on biomarkers and therapeutic strategies in breast cancer.
               A  phase III randomized clinical trial.  Clin Cancer Res.   Transl Cancer Res. 2023;12(6):1617-1634.
               2022;28(5):851-859.                                doi: 10.21037/tcr-22-2807
               doi: 10.1158/1078-0432.CCR-21-3032
                                                               88.  Dall’Acqua A, Bartoletti M, Masoudi-Khoram N,  et al.
            78.  Johnston S, Martin M, Di Leo A, et al. MONARCH 3 final   Inhibition of CDK4/6 as therapeutic approach for ovarian
               PFS: A randomized study of abemaciclib as initial therapy   cancer patients: Current evidences and future perspectives.
               for advanced breast cancer. NPJ Breast Cancer. 2019;5:5.  Cancers (Basel). 2021;13(12):3035.
               doi: 10.1038/s41523-018-0097-z                     doi: 10.3390/cancers13123035
            79.  Sledge GW Jr., Toi M, Neven P,  et al. MONARCH 2:   89.  Lelliott EJ, McArthur GA, Oliaro J, Sheppard KE.
               Abemaciclib in combination with fulvestrant in women   Immunomodulatory effects of BRAF, MEK, and CDK4/6
               with HR+/HER2-  advanced breast cancer who had     inhibitors: Implications for combining targeted therapy
               progressed while receiving endocrine therapy. J Clin Oncol.   and immune checkpoint blockade for the treatment of
               2017;35(25):2875-2884.                             melanoma. Front Immunol. 2021;12:661737.
               doi: 10.1200/JCO.2017.73.7585                      doi: 10.3389/fimmu.2021.661737


            Volume 4 Issue 3 (2025)                         30                           doi: 10.36922/TD025190037
   33   34   35   36   37   38   39   40   41   42   43