Page 17 - manuscript_ijb05580
P. 17

Figure 2. Characterizations of PMs. (A, B) SEM images of particles, (C) and a cross-sectional


               view, (D) particle size distribution, and (E) pore size distribution of the PMs.



                    Notably, the degradability attribute of the biomaterials is equally important to exploring the

               characterization and performance efficacy. To this end, PMs were placed in PBS and incubated for


               7 weeks to investigate its degradation properties. As presented in Figure S2, although PLGA was

               gradually degraded, the porous structure of PMs remained intact for several weeks, which was the


               most suitable carrier for cells, while the slow degradation of PMs favored biomaterial absorption

               and tissue formation 49-51 . In addition, we used protein adsorption effects to explore cell adhesion


               effects on the surface of the PMs by exposing the PMs to serum proteins and evaluating them using

               the Bradford protein assay following the manufacturer's instructions. The results showed that the

                                                                 -2
               adsorption kinetics of the protein was about 1.40×10  mg/PMs for 30 min, followed by equilibrium.

               (Figure  S3).  Collectively,  the  characterizations,  degradability,  and  protein  adsorption  efficacy



                                                             16
   12   13   14   15   16   17   18   19   20   21   22