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printing combined with living cells or extracellular vesicles and gene editing

technologies should be integrated into the hydrogel design to achieve targeted cell

differentiation and on-demand synthesis of ECM components by constructing a
“material-cell-gene” trinity treatment system. At the same time, the AI auxiliary

material platform was designed to accelerate the 3D printing water gel component

optimization process, high-throughput experimental data through the analysis of the

machine learning algorithms. It can reverse guide the design of hydrogel ink

formulation and printing parameters, and promote the rapid development of

personalized hydrogel dressings. It was worth noting that gastrointestinal surgical

incisions and diabetic wounds have common pathological characteristics, but their

microenvironment differences also need to be designed accordingly. Therefore, when

designing multifunctional 3D printed hydrogels, modular strategies, such as the surface

of gastrointestinal wound scaffolds coated with acid-resistant coatings, so as to form a

cross-indication treatment strategy.

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