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Advanced Ne
Advanced Neurologyurology Editorial

aspects and levels. Thus, as long as the research is original, important adverse reaction, that is, amyloid-related
innovative, and significant for clinical work, we will imaging abnormalities (ARIA), in which the mechanisms,
consider them valuable and significant to the literature of risk factors, identification methods, and administration
the neurology and neuroscience research. We summarize processes of ARIA are discussed.
the strong points of Advanced Neurology in the following: The second original research article is about CSVD.

1. The journal encompasses a wide range of research In this article, the authors suggest that decreased cortical
topics and integrates multiple disciplines surrounding thickness, but normal ReHo in right anterior cingulate
neurological diseases, to push forward the development gyrus, right cuneus, bilateral insula, and right middle
of neurology and neuroscience and provide guidance temporal gyrus could predict cognitive impairment in
to clinical work. CSVD patients. Therefore, this provides valuable guidance
2. The journal welcomes various types of articles, for the early intervention of CSVD. The next article
including original research, review articles, letters, presents the meta-analysis of the manifestations and
case reports, opinion pieces and so on. outcomes of COVID-19-associated acute ischemic stroke
3. The journal adopts an efficient workflow to process all using data from PubMed, Embase, and Web of Science
submissions. The editors will make a preliminary decision up to November 29, 2021. Another systematic review
within 7 days, and the first editorial decision within published in this inaugural issue is about gastrointestinal
30 days. Constructive comments will be contributed by symptoms and the possible mechanisms in the early stages
peer reviewers and editors to guide authors in revising of PD, which is of great significance not only for clinical
the papers that are considered for publication. diagnosis and treatment but also for basic research.
The first issue of Advanced Neurology contains articles The third review article summarizes the function and
about stroke, cerebral small vessel disease (CSVD), mechanism of reactive oxygen species (ROS) mediated
Alzheimer’s disease (AD), and Parkinson’s disease (PD) by TRPM2 in neurological disorders, including PD, AD,
in the form of original article, review, case report, meta- stroke, traumatic brain injury, and depressive disorders. It
analysis, and basic research. also provides strategies to inhibit ROS, common pathologic
At present, one of the biggest predicaments for clinical reactions of above-mentioned diseases by controlling
practice is a lack of effective medicine for the treatment of TRPM2. Finally, a case report indicates that large artery
AD. The first original research article we have published atherosclerosis could be the etiology of stroke in patient
shows that the intracellular cAMP receptor EPAC2 with multiple infarcts, which was confirmed by territorial
caused the abnormal hyperphosphorylation at multiple arterial spin labeling perfusion magnetic resonance
AD-associated epitopes by activating CDK5 in a classical imaging.
AD model of Tg2576 mice. This article sheds light on an We hope that our readers find the articles in the
important mechanism and suggests a new therapeutic inaugural issue of Advanced Neurology inspiring to their
target for AD. Aducanumab is so far the only anti-Aβ drug clinical and research work. Furthermore, we sincerely
approved by the US Food and Drug Administration for welcome submissions from you, to publish new research,
AD, which can significantly reduce brain Aβ deposition insights, and results in the upcoming issues of Advanced
(a hallmark of AD). To avoid side effects of aducanumab, Neurology. Your trust is of great importance to keeping
the experts of “Pre-AD Alliance of China” discussed the journal dynamic and bringing value to physicians and
and reached a consensus on the most common and researchers in this field.

Volume 1 Issue 1 (2022) 2 https://doi.org/10.36922/an.v1i1.53