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Advanced Neurology

SHORT COMMUNICATION
Associations of common variants in TAAR5,

OR6C70, and GBA with hyposmia in Han Chinese
individuals with Parkinson’s disease

1†
1†
Yi-Lun Ge , Pu-Zhi Wang , Jia-Hui Yan , Wen Li , Jin-Ru Zhang , Hong Jin ,
1
1
1
1
2
1
Ya-Ping Yang , Fen Wang , Dan Li , Jing Chen , Kai Li *, Cheng-Jie Mao *, and
3
1,3
1
1
Chun-Feng Liu 1,2,3
1 Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
2 Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, China
3 Department of Neurology, Suqian First Hospital, Suqian, China
Abstract
Hyposmia is one of the cardinal symptoms of Parkinson’s disease (PD), with a
considerably high prevalence rate in PD individuals. However, some individuals still
retain normal olfactory function. Recent studies have shown that genetic factors
may play a role in such a phenomenon. This study aimed to explore the potential
genetic factors underlying the variation of olfactory function among PD individuals.
Two hundred and three Han Chinese individuals with PD were recruited into this
† These authors contributed equally study. All the individuals underwent detailed clinical assessment conducted by
to this work. experienced neurologists. High-throughput sequencing was performed to identify
*Corresponding authors: gene variants associated with PD. TAAR5, OR6C70, and GBA were included in the
Kai Li (liskai@126.com)
Cheng-Jie Mao association analysis. In our study, 85 out of 203 individuals (41.9%) reported normal
(drchengjiemao@163.com) olfaction, and the other 118 (58.1%) reported hyposmia. Genotype and allele
logistic regression models were applied to association analysis. We did not find any
Citation: Ge Y-L, Wang P-Z,
Yan J-H, et al., 2022, Associations significant association of TAAR5 and OR6C70 with hyposmia. However, we found that
of common variants in TAAR5, GBA rs762488 was associated with increased hyposmia risk (P = 0.036, OR = 3.05,
OR6C70 and GBA with hyposmia 95% CI = 1.08–8.63), while GBA rs1800438 was associated with decreased hyposmia
in Han Chinese individuals with
Parkinson’s disease. Adv Neuro, risk (P = 0.032, OR = 0.47, 95% CI = 0.24–0.94). In conclusion, this study revealed the
1(2): 71. association of GBA with hyposmia, indicating the genetic involvement in PD hyposmia
https://doi.org/10.36922/an.v1i2.71 variation. However, we did not replicate previous results (TAAR5 and OR6C70) in this
Received: April 17, 2022 study. Further studies with larger sample sizes in different populations are warranted.
Accepted: May 31, 2022
Published Online: July 27, 2022 Keywords: Parkinson’s disease; Olfaction; TAAR5; OR6C70; GBA
Copyright: © 2022 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution 1. Introduction
License, permitting distribution,
and reproduction in any medium, The olfactory system is the bodily structures that serve the sense of smell and enable
provided the original work is animals to identify the environmental information from specific odors . Hyposmia is
[1]
properly cited.
characterized by the loss of odor detection, identification, or memory and is a common
[2]
Publisher’s Note: AccScience [2,3]
Publishing remains neutral with symptom in a plethora of neurodegenerative diseases .
regard to jurisdictional claims in More than half of Parkinson’s disease (PD) individuals reported hyposmia , which
[4]
published maps and institutional
affiliations. precedes the occurrence of motor symptoms. However, olfactory function remains
Volume 1 Issue 2 (2022) 1 https://doi.org/10.36922/an.v1i2.71