Page 51 - AN-1-3
P. 51
Advanced Neurology The diagnosis and treatment of anti-LGI1 autoimmune encephalitis
https://doi.org/10.1523/JNEUROSCI.3506-13.2013 17. Fukata Y, Adesnik H, Iwanaga T, et al., 2006, Epilepsy-related
ligand/receptor complex LGI1 and ADAM22 regulate
6. Fukata Y, Lovero KL, Iwanaga T, et al., 2010, Disruption of synaptic transmission. Science, 313: 1792–1795.
LGI1-linked synaptic complex causes abnormal synaptic
transmission and epilepsy. Proc Natl Acad Sci U S A, https://doi.org/10.1126/science.1129947
107: 3799–3804.
18. Lancaster E, Burnor E, Zhang J, et al., 2019, ADAM23 is
https://doi.org/10.1073/pnas.0914537107 a negative regulator of Kv1.1/Kv1.4 potassium currents.
Neurosci Lett, 704: 159–163.
7. Petit-Pedrol M, Sell J, Planaguma J, et al., 2018, LGI1
antibodies alter Kv1.1 and AMPA receptors changing synaptic https://doi.org/10.1016/j.neulet.2019.04.012
excitability, plasticity and memory. Brain, 141: 3144–3159. 19. Ramberger M, Berretta A, Tan JM, et al., 2020, Distinctive
https://doi.org/10.1093/brain/awy253 binding properties of human monoclonal LGI1 autoantibodies
determine pathogenic mechanisms. Brain, 143: 1731–1745.
8. Acsady L, Kamondi A, Sik A, et al., 1998, GABAergic cells
are the major postsynaptic targets of mossy fibers in the rat https://doi.org/10.1093/brain/awaa104
hippocampus. J Neurosci, 18: 3386–3403. 20. Muniz-Castrillo S, Vogrig A, Honnorat J, et al., 2020,
9. Kalachikov S, Evgrafov O, Ross B, et al., 2002, Mutations Associations between HLA and autoimmune neurological
in LGI1 cause autosomal-dominant partial epilepsy with diseases with autoantibodies. Auto Immun Highlights, 11: 2.
auditory features. Nat Genet, 30: 335–341. https://doi.org/10.1186/s13317-019-0124-6
https://doi.org/10.1038/ng832 21. Hu F, Liu X, Zhang L, et al., 2020, Novel findings of HLA
10. Morante-Redolat JM, Gorostidi-Pagola A, Piquer-Sirerol S, association with anti-LGI1 encephalitis: HLA-DRB1*03:01
et al., 2002, Mutations in the LGI1/epitempin gene on 10q24 and HLA-DQB1*02:01. J Neuroimmunol, 344: 577243.
cause autosomal dominant lateral temporal epilepsy. Hum https://doi.org/10.1016/j.jneuroim.2020.577243
Mol Genet, 11: 1119–1128.
22. Binks S, Varley J, Lee W, et al., 2018, Distinct HLA
https://doi.org/10.1093/hmg/11.9.1119 associations of LGI1 and CASPR2-antibody diseases. Brain,
11. Yuko F, Xiumin C, Satomi C, et al., 2021, LGI1-ADAM22- 141: 2263–2271.
MAGUK configures transsynaptic nanoalignment for https://doi.org/10.1093/brain/awy109
synaptic transmission and epilepsy prevention. Proc Natl
Acad Sci U S A, 118: e2022580118. 23. Mueller SH, Farber A, Pruss H, et al., 2018, Genetic
predisposition in anti-LGI1 and anti-NMDA receptor
https://doi.org/10.1073/pnas.2022580118 encephalitis. Ann Neurol, 83: 863–869.
12. Fels E, Muniz-Castrillo S, Vogrig A, et al., 2021, Role of https://doi.org/10.1002/ana.25216
LGI1 protein in synaptic transmission: From physiology to
pathology. Neurobiol Dis, 160: 105537. 24. Kim TJ, Lee ST, Moon J, et al., 2017, Anti-LGI1 encephalitis
is associated with unique HLA subtypes. Ann Neurol,
https://doi.org/10.1016/j.nbd.2021.105537 81: 183–192.
13. Guan D, Lee JC, Tkatch T, et al., 2006, Expression and https://doi.org/10.1002/ana.24860
biophysical properties of Kv1 channels in supragranular
neocortical pyramidal neurones. J Physiol, 571(Pt 2): 371–389. 25. Van Sonderen A, Roelen DL, Stoop JA, et al., 2017, Anti-
LGI1 encephalitis is strongly associated with HLA-DR7 and
https://doi.org/10.1113/jphysiol.2005.097006 HLA-DRB4. Ann Neurol, 81: 193–198.
14. Henley JM, Nair JD, Seager R, et al., 2021, Kainate and AMPA https://doi.org/10.1002/ana.24858
receptors in epilepsy: Cell biology, signalling pathways and 26. Ding C, Sun Q, Li R, et al., 2022, The first case of familiar anti-
possible crosstalk. Neuropharmacology, 195: 108569.
leucine-rich glioma-inactivated 1 autoimmune encephalitis:
https://doi.org/10.1016/j.neuropharm.2021.108569 A case report and literature review. Front Neurol, 13: 855383.
15. Boillot M, Lee CY, Allene C, et al., 2016, LGI1 acts https://doi.org/10.3389/fneur.2022.855383
presynaptically to regulate excitatory synaptic transmission 27. Muniz-Castrillo S, Haesebaert J, Thomas L, et al., 2021, Clinical
during early postnatal development. Sci Rep, 6: 21769.
and prognostic value of immunogenetic characteristics in
https://doi.org/10.1038/srep21769 anti-LGI1 encephalitis. Neurol Neuroimmunol Neuroinflamm,
8: e974.
16. Zhou YD, Lee S, Jin Z, et al., 2009, Arrested maturation of
excitatory synapses in autosomal dominant lateral temporal https://doi.org/10.1212/NXI.0000000000000974
lobe epilepsy. Nat Med, 15: 1208–1214.
28. Taneja V, 2018, Sex hormones determine immune response.
https://doi.org/10.1038/nm.2019 Front Immunol, 9: 1931.
Volume 1 Issue 3 (2022) 8 https://doi.org/10.36922/an.v1i3.237

