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Advanced Neurology PSD-95 in neurodevelopmental disorders

Table 2. (Continued)
Medications Author Model Disease model Treatment Results Conclusion
(vii) Imipramine
(0.1, 1, and
10 µM)
Reinés Wistar rats Learned helpless Fluoxetine (10 mg/kg) Fluoxetine: Decrease in Exploring mechanisms that
et al. 95 despaired behavior induced play a role in maintaining
by exposure to LH paradigm synaptic alterations could
and increase in synaptophysin, be promising avenues for
PSD-95 and GAP-43. No effect researching treatments for
on hippocampus NFL and any depression and preventing its
other cytoskeletal protein. recurrence.
Liu ICR CUMS Ferulic acid Ferulic acid: Improved Ferulic acid demonstrated
et al. 97 (CD1) (20 or 40 mg/kg) CUMS-induced depressive-like antidepressant-like effects in
mice behaviors and increased CUMS mice by raising the
levels of BDNF, PSD-95, and levels of synaptic proteins
synapsin I in the prefrontal associated with neurotrophins.
cortex and hippocampus
Li WKY rats Endogenous Citalopram Citalopram: Increase in WKY rats exhibited
et al. 98 depression model (10 mg/kg) PSD-95 and synaptophysin impaired synaptic plasticity,
expression in HPC and PFC, and antidepressants can
and increase in the dendritic influence this condition. This
spine in the hippocampus and information aids in gaining a
prefrontal cortex deeper understanding of the
structural MRI alterations
in the hippocampus and
prefrontal cortex.
Alpha-2 agonists Hains SD rats Chronic stress Guanfacine Guanfacine: Weight gain Guanfacine could shield the
et al. 106 (0.1 mg/kg) delayed, protected spine gray matter of the PFC from
density, partially normalized the harmful consequences of
apical dendritic length. stress.
Increase in distal apical spine
density is for the proximal
region of basal dendrites, spine
density in the distal portion
of basal dendrites, and basal
dendritic length
Other treatments Prickaert Sows and LBW Allopurinol Allopurinol: Increase in BDNF, Administering allopurinol
et al. 112 piglets (15 mg/kg) PSD-95, and pCREB/CREB treatment could be a hopeful
ration strategy for low birth weight
(LBW) neonates.
Lisek Wistar rats Drug test Ketamine (30 mg/kg) Higher PSD95 protein levels in Specific changes in the
et al. 119 the cerebellum, hippocampus, clustering of PSD-95 with
and striatum. No changes in NMDA receptor subunits
NMDAR subunit expression in specific brain regions
could influence local calcium
signaling and affect how
cells respond to ketamine
administration.
Abbreviations: ACC: Anterior cingulate cortex; AMPAR: α-amino-3-hydroxy-5-methyl-4-isox-azoleproprionic acid receptors; BCCAO: Bilateral
typical carotid artery occlusion; BDNF: Brain-derived neurotrophic factor; CUMS: Chronic unpredictable mild stress; GAP-43: Growth-associated
protein 43; GSK: Glycogen synthase kinase; HPC: Hippocampus; LBW: Low birth weight; LH: Learned helplessness; MAC: Medial agranular cortex;
MC: Motor cortex; NFL: Light neurofilament subunit; NMDAR: N-methyl-d-aspartic acid receptors; PFC: prefrontal cortex; PSD-95: Postsynaptic
density-95; SD: Sprague-Dawley; SYN: synaptophysin; WKY: Wistar-Kyoto; NA: Not available
treated with olanzapine (100 µM) and aripiprazole (10 µM) or without B27. In addition, quetiapine (10 µM) inhibited
for 5 days increased brain-derived neurotrophic factor the reduction of these proteins, generally observed with
(BDNF) and PSD-95 protein levels when incubated with B27 deprivation. Likewise, 1 µM of clozapine and 1 µM or

Volume 3 Issue 1 (2024) 8 https://doi.org/10.36922/an.2095