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Advanced Neurology                                                  PSD-95 in neurodevelopmental disorders



              In summary, understanding the role of PSD-95 in     plasticity and networks: Implications for neurodevelopmental
            NDDs and its implications for synaptic plasticity and   disorders. Neuron. 2012;76(1):175-191.
            dendritic spine morphology offers potential avenues for      doi: 10.1016/j.neuron.2012.09.013
            improving understanding of established therapies and   5.   Zoghbi HY, Bear MF. Synaptic dysfunction in
            for developing novel therapeutic strategies to alleviate the   neurodevelopmental disorders associated with autism and
            cognitive, emotional, and motor deficits associated with   intellectual disabilities.  Cold Spring Harb Perspect Biol.
            NDDs.                                                 2012;4(3):a009886.

            Acknowledgments                                       doi: 10.1101/cshperspect.a009886
            None.                                              6.   Turrigiano GG, Nelson SB. Homeostatic plasticity
                                                                  in the developing nervous system.  Nat Rev Neurosci.
            Funding                                               2004;5(2):97-107.
            None.                                                 doi: 10.1038/nrn1327
                                                               7.   Citri A, Malenka RC. Synaptic plasticity: Multiple forms,
            Conflict of interest                                  functions,  and  mechanisms.  Neuropsychopharmacol.
                                                                  2008;33(1):18-41.
            The authors declare that they have no conflict of interest.
                                                                  doi: 10.1038/sj.npp.1301559
            Author contributions
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            Conceptualization: All authors                        with hippocampal long-term synaptic plasticity.  Nature.
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            Writing – review & editing: All authors               doi: 10.1038/19978
            All authors have read and agreed to the published version   9.   Bliss TVP, Collingridge GL. A synaptic model of memory:
            of the manuscript.                                    Long-term potentiation in the hippocampus.  Nature.
                                                                  1993;361(6407):31-39.
            Ethics approval and consent to participate            doi: 10.1038/361031a0

            Not applicable.                                    10.  Malinow R, Schulman H, Tsien RW. Inhibition of
                                                                  postsynaptic PKC or CaMKII blocks induction but not
            Consent for publication                               expression of LTP. Science. 1989;245(4920):862-866.
            Not applicable.                                       doi: 10.1126/science.2549638

            Availability of data                               11.  Coley  AA,  Gao  WJ.  PSD-95  deficiency  disrupts  PFC-
                                                                  associated function and behavior during neurodevelopment.
            Not applicable.                                       Sci Rep. 2019;9(1):9486.

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