Page 59 - AN-3-2
P. 59
Advanced Neurology Inflammation in diabetic stroke: Pathogenesis
doi: 10.1186/s12902-020-0511-z phase of peri-infarct depolarizations after focal cerebral
ischemia: Relation to infarct growth and neuroprotection.
30. Hukshorn CJ, Saris WH. Leptin and energy expenditure.
Curr Opin Clin Nutr Metab Care. 2004;7(6):629-633. J Neurosci. 2003;23(37):11602-11610.
doi: 10.1523/JNEUROSCI.23-37-11602.2003
doi: 10.1097/00075197-200411000-00007
42. Saeed SA, Shad KF, Saleem T, Javed F, Khan MU. Some new
31. Saxton RA, Caveney NA, Moya-Garzon MD, et al. Structural
insights into the mechanism of leptin receptor activation. prospects in the understanding of the molecular basis of the
Nat Commun. 2023;14(1):1797. pathogenesis of stroke. Exp Brain Res. 2007;182(1):1-10.
doi: 10.1007/s00221-007-1050-9
doi: 10.1038/s41467-023-37169-6
43. Gulke E, Gelderblom M, Magnus T. Danger signals in stroke
32. Raman P, Khanal S. Leptin in atherosclerosis: Focus on
macrophages, endothelial and smooth muscle cells. Int J Mol and their role on microglia activation after ischemia. Ther
Adv Neurol Disord. 2018;11:1756286418774254.
Sci. 2021;22(11):5446.
doi: 10.1177/1756286418774254
doi: 10.3390/ijms22115446
44. Poznyak AV, Melnichenko AA, Wetzker R, Gerasimova EV,
33. Dong Z, Zhuang Q, Ye X, et al. Adiponectin inhibits NLRP3 Orekhov AN. NLPR3 inflammasomes and their significance
inflammasome activation in nonalcoholic steatohepatitis via for atherosclerosis. Biomedicines. 2020;8(7):205.
AMPK-JNK/ErK1/2-NFκB/ROS signaling pathways. Front
Med (Lausanne). 2020;7:546445. doi: 10.3390/biomedicines8070205
doi: 10.3389/fmed.2020.546445 45. Bellut M, Papp L, Bieber M, Kraft P, Stoll G, Schuhmann MK.
NLPR3 inflammasome inhibition alleviates hypoxic
34. Begum M, Choubey M, Tirumalasetty MB, et al. Adiponectin: endothelial cell death in vitro and protects blood-
A promising target for the treatment of diabetes and its brain barrier integrity in murine stroke. Cell Death Dis.
complications. Life (Basel). 2023;13(11):2213.
2021;13(1):20.
doi: 10.3390/life13112213
doi: 10.1038/s41419-021-04379-z
35. Gindri Dos Santos B, Goedeke L. Macrophage
immunometabolism in diabetes-associated atherosclerosis. 46. Hong P, Gu RN, Li FX, et al. NLRP3 inflammasome as a
Immunometabolism (Cobham). 2023;5(4):e00032. potential treatment in ischemic stroke concomitant with
diabetes. J Neuroinflammation. 2019;16(1):121.
doi: 10.1097/IN9.0000000000000032
doi: 10.1186/s12974-019-1498-0
36. Nagareddy PR, Murphy AJ, Stirzaker RA, et al. Hyperglycemia
promotes myelopoiesis and impairs the resolution of 47. Przykaza L. Understanding the connection between common
atherosclerosis. Cell Metab. 2013;17(5):695-708. stroke comorbidities, their associated inflammation, and the
course of the cerebral Ischemia/Reperfusion cascade. Front
doi: 10.1016/j.cmet.2013.04.001 Immunol. 2021;12:782569.
37. Flynn MC, Kraakman MJ, Tikellis C, et al. Transient doi: 10.3389/fimmu.2021.782569
intermittent hyperglycemia accelerates atherosclerosis by
promoting myelopoiesis. Circ Res. 2020;127(7):877-892. 48. Franke M, Bieber M, Kraft P, Weber ANR, Stoll G,
Schuhmann MK. The NLRP3 inflammasome drives
doi: 10.1161/CIRCRESAHA.120.316653 inflammation in ischemia/reperfusion injury after transient
38. Kanter JE, Hsu CC, Bornfeldt KE. Monocytes and middle cerebral artery occlusion in mice. Brain Behav
macrophages as protagonists in vascular complications of Immun. 2021;92:223-233.
diabetes. Front Cardiovasc Med. 2020;7:10. doi: 10.1016/j.bbi.2020.12.009
doi: 10.3389/fcvm.2020.00010 49. Cai Y, Leng S, Ma Y, Xu T, Chang D, Ju S. Dynamic
change of MMP-9 in diabetic stroke visualized by optical
39. Kaur R, Kaur M, Singh J. Endothelial dysfunction and
platelet hyperactivity in type 2 diabetes mellitus: Molecular imaging and treated with CD28 superagonist. Biomater Sci.
insights and therapeutic strategies. Cardiovasc Diabetol. 2021;9(7):2562-2570.
2018;17(1):121. doi: 10.1039/d0bm02014a
doi: 10.1186/s12933-018-0763-3 50. Ravanan P, Srikumar IF, Talwar P. Autophagy: The spotlight
for cellular stress responses. Life Sci. 2017;188:53-67.
40. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of
ischaemic stroke: An integrated view. Trends Neurosci. doi: 10.1016/j.lfs.2017.08.029
1999;22(9):391-397.
51. Mo Y, Sun YY, Liu KY. Autophagy and inflammation in
doi: 10.1016/s0166-2236(99)01401-0 ischemic stroke. Neural Regen Res. 2020;15(8):1388-1396.
41. Hartings JA, Rolli ML, Lu XC, Tortella FC. Delayed secondary doi: 10.4103/1673-5374.274331
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