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Advanced Neurology Tau pathology in murine TBI

tau as the earliest detectable pathogenic conformation in 62. Folkerts MM, Parks EA, Dedman JR, Kaetzel MA, Lyeth BG,
Alzheimer disease, offering novel diagnostic and therapeutic Berman RF. Phosphorylation of calcium calmodulin-
strategies. Prion. 2013;7(2):117-120. dependent protein kinase II following lateral fluid percussion
brain injury in rats. J Neurotrauma. 2007;24(4):638-650.
doi: 10.4161/pri.22849
doi: 10.1089/neu.2006.0188
53. Ghag G, Bhatt N, Cantu DV, et al. Soluble tau aggregates, not
large fibrils, are the toxic species that display seeding and 63. Farr SA, Niehoff ML, Kumar VB, Roby DA, Morley JE.
cross-seeding behavior. Protein Sci. 2018;27(11):1901-1909. Inhibition of glycogen synthase kinase 3β as a treatment for
the prevention of cognitive deficits after a traumatic brain
doi: 10.1002/pro.3499
injury. J Neurotrauma. 2019;36(11):1869-1875.
54. Petry FR, Pelletier J, Bretteville A, et al. Specificity of
anti-tau antibodies when analyzing mice models of doi: 10.1089/neu.2018.5999
Alzheimer’s disease: Problems and solutions. PLoS One. 64. Zhao ZA, Zhao Y, Ning YL, et al. Adenosine A(2A) receptor
2014;9(5):e94251. inactivation alleviates early-onset cognitive dysfunction
after traumatic brain injury involving an inhibition of tau
doi: 10.1371/journal.pone.0094251
hyperphosphorylation. Transl Psychiatry. 2017;7(5):e1123.
55. Li D, Cho YK. High specificity of widely used phospho-tau
antibodies validated using a quantitative whole-cell based doi: 10.1038/tp.2017.98
assay. J Neurochem. 2020;152(1):122-135. 65. Wang Y, Hall RA, Lee M, Kamgar-Parsi A, Bi X,
Baudry M. The tyrosine phosphatase PTPN13/FAP-1
doi: 10.1111/jnc.14830
links calpain-2, TBI and tau tyrosine phosphorylation. Sci
56. Tran HT, Sanchez L, Brody DL. Inhibition of JNK by a Rep. 2017;7(1):11771.
peptide inhibitor reduces traumatic brain injury-induced
tauopathy in transgenic mice. J Neuropathol Exp Neurol. doi: 10.1038/s41598-017-12236-3
2012;71(2):116-129. 66. Furman JL, Sompol P, Kraner SD, et al. Blockade of
astrocytic calcineurin/NFAT signaling helps to normalize
doi: 10.1097/NEN.0b013e3182456aed
hippocampal synaptic function and plasticity in a rat model
57. Bales JW, Ma X, Yan HQ, Jenkins LW, Dixon CE. Regional of traumatic brain injury. J Neurosci. 2016;36(5):1502-1515.
calcineurin subunit B isoform expression in rat hippocampus
following a traumatic brain injury. Brain Res. 2010;1358: doi: 10.1523/JNEUROSCI.1930-15.2016
211-220. 67. Tapella L, Dematteis G, Ruffinatti FA, et al. Deletion of
calcineurin from astrocytes reproduces proteome signature
doi: 10.1016/j.brainres.2010.08.029
of Alzheimer’s disease and epilepsy and predisposes to
58. Tan Z, Chen L, Ren Y, Jiang X, Gao W. Neuroprotective seizures. Cell Calcium. 2021;100:102480.
effects of FK866 against traumatic brain injury: Involvement
of p38/ERK pathway. Ann Clin Transl Neurol. 2020;7(5): doi: 10.1016/j.ceca.2021.102480
742-756. 68. Chen Y, Holstein DM, Aime S, Bollo M, Lechleiter JD.
Calcineurin beta protects brain after injury by activating the
doi: 10.1002/acn3.51044
unfolded protein response. Neurobiol Dis. 2016;94:139-156.
59. Otani N, Nawashiro H, Fukui S, Nomura N, Shima K.
Temporal and spatial profile of phosphorylated doi: 10.1016/j.nbd.2016.06.011
mitogen-activated protein kinase pathways after lateral 69. Zhao ZA, Li P, Ye SY, et al. Perivascular AQP4 dysregulation
fluid percussion injury in the cortex of the rat brain. in the hippocampal CA1 area after traumatic brain injury
J Neurotrauma. 2002;19(12):1587-1596. is alleviated by adenosine A(2A) receptor inactivation. Sci
Rep. 2017;7(1):2254.
doi: 10.1089/089771502762300247
doi: 10.1038/s41598-017-02505-6
60. Huang S, Ge X, Yu J, et al. Increased miR-124-3p in microglial
exosomes following traumatic brain injury inhibits neuronal 70. Pertwee RG. The diverse CB1 and CB2 receptor pharmacology
inflammation and contributes to neurite outgrowth via their of three plant cannabinoids: Delta9-tetrahydrocannabinol,
transfer into neurons. FASEB J. 2018;32(1):512-528. cannabidiol and delta9-tetrahydrocannabivarin. Br J
Pharmacol. 2008;153(2):199-215.
doi: 10.1096/fj.201700673R
doi: 10.1038/sj.bjp.0707442
61. Zhao S, Fu J, Liu X, Wang T, Zhang J, Zhao Y. Activation of
Akt/GSK-3beta/beta-catenin signaling pathway is involved 71. Yin Z, Han Z, Hu T, et al. Neuron-derived exosomes with
in survival of neurons after traumatic brain injury in rats. high miR-21-5p expression promoted polarization of M1
Neurol Res. 2012;34(4):400-407. microglia in culture. Brain Behav Immun. 2020;83:270-282.
doi: 10.1179/1743132812Y.0000000025 doi: 10.1016/j.bbi.2019.11.004

Volume 3 Issue 3 (2024) 11 doi: 10.36922/an.3213