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Advanced Neurology TMAO and stroke

control the plasma level of TMAO so as to bring down regulation. Cell Metab. 2013;17(1):49-60.
the risks for IS. Despite the notable clinical association doi: 10.1016/j.cmet.2012.12.011
between TMAO levels and IS risk, the precise mechanisms
relating TMAO levels to IS are still unclear. Future research 2. Hosseinkhani F, Heinken A, Thiele I, Lindenburg PW,
is warranted to delineate the precise relationship between Harms AC, Hankemeier T. The contribution of gut bacterial
metabolites in the human immune signaling pathway of
TMAO and the increased risk of cerebrovascular events, as non-communicable diseases. Gut Microbes. 2021;13(1):1-22.
well as to leverage our understanding of their relationship
to devise and implement timely and effective intervention doi: 10.1080/19490976.2021.1882927
measures with the aim of lowering rates of morbidity and 3. Li D, Lu Y, Yuan S, et al. Gut microbiota-derived metabolite
disability while improving clinical prognosis. trimethylamine-N-oxide and multiple health outcomes: An
umbrella review and updated meta-analysis. Am J Clin Nutr.
Acknowledgments 2022;116(1):230-243.
None. doi: 10.1093/ajcn/nqac074
Funding 4. Fretts AM, Hazen SL, Jensen P, et al. Association of
trimethylamine N-oxide and metabolites with mortality in
The study was supported by the National Health older adults. JAMA Netw Open. 2022;5(5):e2213242.
Commission Brain Prevention Committee “Research doi: 10.1001/jamanetworkopen.2022.13242
and Promotion Project of Appropriate Technology
Intervention for High-risk Groups of Stroke in China” 5. Duttaroy AK. Role of gut microbiota and their metabolites
(GN-2018R0009) and Xuzhou Promoting Science and on atherosclerosis, hypertension and human blood platelet
Technology Innovation Project (KC22241). function: A review. Nutrients. 2021;13(1):144.
doi: 10.3390/nu13010144
Conflict of interest
6. Han S, Cai L, Chen P, Kuang W. A study of the correlation
De-Qin Geng serves as the Editorial Board Member of this between stroke and gut microbiota over the last 20 years: A
journal, but did not in any way involved in the editorial bibliometric analysis. Front Microbiol. 2023;14:1191758.
and peer-review process conducted for this paper, directly doi: 10.3389/fmicb.2023.1191758
or indirectly. Separately, others authors declare that they
have no known competing financial interests or personal 7. Zhang W, Dong XY, Huang R. Gut microbiota in ischemic
relationships that could have appeared to influence the stroke: Role of gut bacteria-derived metabolites. Transl
work reported in this paper. Stroke Res. 2023;14(6):811-828.
doi: 10.1007/s12975-022-01096-3
Author contributions
8. Lüscher TF. They eat what we eat, they digest what we ingest.
Conceptualization: Qi-Yang Yuan, Yao-Wu Liu, Shuo Li, Eur Heart J. 2023;44(18):1619-1621.
Jin-Jin Yang, De-Qin Geng doi: 10.1093/eurheartj/ehad104
Writing – original draft: Qi-Yang Yuan, Yao-Wu Liu, Bao-
Xin Wu, Fen-Fang Gao, Yu-Kun Wang, Chu Zhou 9. Ufnal M, Zadlo A, Ostaszewski R. TMAO: A small molecule
Writing – review & editing: Shi-Guang Zhu, De-Qin Geng of great expectations. Nutrition. 2015;31(11-12):1317-1323.
doi: 10.1016/j.nut.2015.05.006
Ethics approval and consent to participate
10. Pham QD, Wolde-Kidan A, Gupta A, et al. Effects of urea
Not applicable. and TMAO on lipid self-assembly under osmotic stress
conditions. J Phys Chem B. 2018;122(25):6471-6482.
Consent for publication
doi: 10.1021/acs.jpcb.8b02159
Not applicable.
11. Tu WJ, Wang LD. China stroke surveillance report 2021. Mil
Availability of data Med Res. 2023;10(1):33.
doi: 10.1186/s40779-023-00463-x
Not applicable.
12. Hu X, Ren H, Cao Y. The association between trimethylamine
References N-oxide levels and ischemic stroke occurrence: A meta-
analysis and Mendelian randomization study. BMC Neurol.
1. Bennett BJ, de Aguiar Vallim TQ, Wang Z, et al.
Trimethylamine-N-oxide, a metabolite associated with 2023;23(1):413.
atherosclerosis, exhibits complex genetic and dietary doi: 10.1186/s12883-023-03458-2

Volume 3 Issue 3 (2024) 6 doi: 10.36922/an.3005