Page 46 - AN-3-3
P. 46

Advanced Neurology                                                                   TMAO and stroke



            34.  Jenny NS, Callas PW, Judd SE, et al. Inflammatory cytokines   concentration is positively associated with first stroke in
               and ischemic stroke risk: The REGARDS cohort. Neurology.   hypertensive patients. Stroke. 2018;49(9):2021-2028.
               2019;92(20):e2375-e2384.
                                                                  doi: 10.1161/STROKEAHA.118.021997
               doi: 10.1212/WNL.0000000000007416
                                                               45.  Kamel  H,  Healey  JS.  Cardioembolic  stroke.  Circ Res.
            35.  Alsbrook DL, Di Napoli M, Bhatia K, et al. Neuroinflammation   2017;120(3):514-526.
               in  acute  ischemic  and hemorrhagic  stroke.  Curr Neurol      doi: 10.1161/CIRCRESAHA.116.308407
               Neurosci Rep. 2023;23(8):407-431.
                                                               46.  Liu Y, Qu J, Xu J, et al. Trimethylamine-N-oxide: A potential
               doi: 10.1007/s11910-023-01282-2
                                                                  biomarker and therapeutic target in ischemic stroke. Front
            36.  Farhangi MA, Vajdi M. Novel findings of the association   Neurol. 2023;14:1156879.
               between gut microbiota-derived metabolite trimethylamine      doi: 10.3389/fneur.2023.1156879
               N-oxide  and inflammation:  Results  from  a  systematic
               review and dose-response meta-analysis. Crit Rev Food Sci   47.  Cryan JF, Dinan TG. Mind-altering microorganisms: The
               Nutr. 2020;60(16):2801-2823.                       impact of the gut microbiota on brain and behaviour. Nat
                                                                  Rev Neurosci. 2012;13(10):701-712.
               doi: 10.1080/10408398.2020.1770199
                                                                  doi: 10.1038/nrn3346
            37.  Zhu W, Gregory JC, Org E, et al. Gut microbial metabolite
               TMAO  enhances  platelet  hyperreactivity  and  thrombosis   48.  Spence JD. Diet for stroke prevention. Stroke Vasc Neurol.
               risk. Cell. 2016;165(1):111-124.                   2018;3(2):44-50.
               doi: 10.1016/j.cell.2016.02.011                    doi: 10.1136/svn-2017-000130
            38.  Cheng X, Qiu X, Liu Y, Yuan C, Yang X. Trimethylamine   49.  Wang Z, Bergeron N, Levison BS, et al. Impact of chronic
               N-oxide  promotes  tissue  factor  expression  and activity   dietary red meat, white meat, or non-meat protein on
               in vascular endothelial cells: A  new link between   trimethylamine N-oxide metabolism and renal excretion in
               trimethylamine N-oxide and atherosclerotic thrombosis.   healthy men and women. Eur Heart J. 2019;40(7):583-594.
               Thromb Res. 2019;177:110-116.                      doi: 10.1093/eurheartj/ehy799
               doi: 10.1016/j.thromres.2019.02.028             50.  Coutinho-Wolino KS, de F Cardozo L, de Oliveira Leal V,
            39.  Witkowski M, Witkowski M, Friebel J,  et al. Vascular   Mafra D, Stockler-Pinto MB. Can diet modulate
               endothelial tissue factor contributes to trimethylamine   trimethylamine N-oxide (TMAO) production? What do we
               N-oxide-enhanced arterial  thrombosis.  Cardiovasc Res.   know so far. Eur J Nutr. 2021;60(7):3567-3584.
               2022;118(10):2367-2384.                            doi: 10.1007/s00394-021-02491-6
               doi: 10.1093/cvr/cvab263                        51.  Tenore GC, Caruso D, Buonomo G, et al. Lactofermented
            40.  Jomard A, Liberale L, Doytcheva P,  et al. Effects of acute   Annurca apple puree as a functional food indicated for
               administration of trimethylamine N-oxide on endothelial   the control of plasma lipid and oxidative amine levels:
               function: A translational study. Sci Rep. 2022;12(1):8664.  Results from a randomised clinical trial.  Nutrients. 2019;
                                                                  11(1):122.
               doi: 10.1038/s41598-022-12720-5
                                                                  doi: 10.3390/nu11010122
            41.  Zhang  WQ,  Wang  YJ,  Zhang  A,  et al.  TMA/TMAO  in
               hypertension:  Novel  horizons  and  potential  therapies.   52.  Brunt VE, Greenberg NT, Sapinsley ZJ, et al. Suppression
               J Cardiovasc Transl Res. 2021;14(6):1117-1124.     of trimethylamine N-oxide with DMB mitigates vascular
                                                                  dysfunction, exercise intolerance, and frailty associated
               doi: 10.1007/s12265-021-10115-x
                                                                  with a Western-style diet in mice. J  Appl Physiol (1985).
            42.  Ge  X,  Zheng  L,  Zhuang  R,  et al.  The  gut  microbial   2022;133(4):798-813.
               metabolite trimethylamine N-oxide and hypertension risk:      doi: 10.1152/japplphysiol.00350.2022
               A systematic review and dose-response meta-analysis. Adv
               Nutr. 2020;11(1):66-76.                         53.  Oktaviono YH, Dyah Lamara A, Saputra P, et al. The roles of
                                                                  trimethylamine-N-oxide in atherosclerosis and its potential
               doi: 10.1093/advances/nmz064
                                                                  therapeutic aspect: A  literature review.  Biomol Biomed.
            43.  Jiang S, Shui Y, Cui Y,  et al. Gut microbiota dependent   2023;23(6):936-948.
               trimethylamine N-oxide aggravates angiotensin II-induced      doi: 10.17305/bb.2023.8893
               hypertension. Redox Biol. 2021;46:102115.
                                                               54.  Chen  ML,  Yi  L,  Zhang  Y,  et al.  Resveratrol  attenuates
               doi: 10.1016/j.redox.2021.102115
                                                                  trimethylamine-N-oxide (TMAO)-induced atherosclerosis
            44.  Nie J, Xie L, Zhao BX, et al. Serum trimethylamine N-oxide   by regulating TMAO synthesis and bile acid metabolism via



            Volume 3 Issue 3 (2024)                         8                                doi: 10.36922/an.3005
   41   42   43   44   45   46   47   48   49   50   51