Page 83 - AN-3-3
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Advanced Neurology                                                            mTOR inhibition in epilepsy



               streptomycete and isolation of the active principle. J Antibiot   67.  Krueger DA, Wilfong AA, Holland-Bouley K,  et al.
               (Tokyo). 1975;28(10):721-726.                      Everolimus  treatment of  refractory epilepsy  in  tuberous
                                                                  sclerosis complex. Ann Neurol. 2013;74(5):679-687.
               doi: 10.7164/antibiotics.28.721
                                                                  doi: 10.1002/ana.23960
            57.  Oshiro N, Yoshino K, Hidayat S, et al. Dissociation of raptor
               from mTOR is a mechanism of rapamycin-induced inhibition   68.  Franz DN, Belousova E, Sparagana S,  et al. Everolimus
               of mTOR function. Genes Cells. 2004;9(4):359-366.  for subependymal giant cell astrocytoma in patients
                                                                  with tuberous sclerosis complex: 2-year open-label
               doi: 10.1111/j.1356-9597.2004.00727.x
                                                                  extension of the randomised EXIST-1 study. Lancet Oncol.
            58.  Zhou H, Luo Y, Huang S. Updates of mTOR inhibitors.   2014;15(13):1513-1520.
               Anticancer Agents Med Chem. 2010;10(7):571-581.
                                                                  doi: 10.1016/S1470-2045(14)70489-9
               doi: 10.2174/187152010793498663
                                                               69.  French JA, Lawson JA, Yapici Z, et al. Adjunctive everolimus
            59.  Mao B, Zhang Q, Ma L, Zhao DS, Zhao P, Yan P. Overview of   therapy for treatment-resistant focal-onset seizures
               research into mTOR inhibitors. Molecules. 2022;27(16):5295.  associated with tuberous sclerosis (EXIST-3): A  phase 3,
               doi: 10.3390/molecules27165295                     randomised, double-blind, placebo-controlled study. Lancet.
                                                                  2016;388(10056):2153-2163.
            60.  Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA.
               Regulation of mTORC1 and mTORC2 complex assembly by      doi: 10.1016/S0140-6736(16)31419-2
               phosphatidic acid: Competition with rapamycin.  Mol Cell   70.  Franz DN, Lawson JA, Yapici Z, et al. Adjunctive everolimus
               Biol. 2009;29(6):1411-1420.                        therapy for tuberous sclerosis complex-associated refractory
               doi: 10.1128/MCB.00782-08                          seizures: Results from the postextension phase of EXIST-3.
                                                                  Epilepsia. 2021;62(12):3029-3041.
            61.  Foster DA, Toschi A. Targeting mTOR with rapamycin: One
               dose does not fit all. Cell Cycle. 2009;8(7):1026-1029.     doi: 10.1111/epi.17099
               doi: 10.4161/cc.8.7.8044                        71.  Curatolo P, Franz DN, Lawson JA,  et al. Adjunctive
                                                                  everolimus for children and adolescents with treatment-
            62.  Franz DN, Leonard J, Tudor C,  et al. Rapamycin causes   refractory seizures associated with tuberous sclerosis
               regression of astrocytomas in tuberous sclerosis complex.   complex: Post-hoc analysis of the phase 3 EXIST-3 trial.
               Ann Neurol. 2006;59(3):490-498.                    Lancet Child Adolesc Health. 2018;2(7):495-504.
               doi: 10.1002/ana.20784
                                                                  doi: 10.1016/S2352-4642(18)30099-3
            63.  Cardamone M, Flanagan D, Mowat D, Kennedy SE,   72.  Taboada RG, Riechelmann RP, Mauro C, et al. Everolimus-
               Chopra M, Lawson JA. Mammalian target of rapamycin   induced pneumonitis in patients with neuroendocrine
               inhibitors for intractable epilepsy and subependymal giant   neoplasms: Real-world study on risk factors and outcomes.
               cell astrocytomas in tuberous sclerosis complex. J Pediatr.   Oncologist. 2022;27(2):97-103.
               2014;164(5):1195-1200.
                                                                  doi: 10.1093/oncolo/oyab024
               doi: 10.1016/j.jpeds.2013.12.053
                                                               73.  Franz DN, Krueger DA. mTOR inhibitor therapy as a disease
            64.  Franz DN, Lawson JA, Yapici Z,  et al. Everolimus   modifying therapy for tuberous sclerosis complex. Am J Med
               for treatment-refractory seizures in TSC: Extension   Genet C Semin Med Genet. 2018;178(3):365-373.
               of a randomized controlled trial.  Neurol Clin Pract.
               2018;8(5):412-420.                                 doi: 10.1002/ajmg.c.31655
               doi: 10.1212/CPJ.0000000000000514               74.  Baas MC, Gerdes VE, Ten Berge IJ, et al. Treatment with
                                                                  everolimus is associated with a procoagulant state. Thromb
            65.  Krueger DA, Care MM, Holland K,  et al. Everolimus for   Res. 2013;132(2):307-311.
               subependymal giant-cell astrocytomas in tuberous sclerosis.
               N Engl J Med. 2010;363(19):1801-1811.              doi: 10.1016/j.thromres.2013.07.004
               doi: 10.1056/NEJMoa1001671                      75.  Duerr M, Glander P, Diekmann F, Dragun D, Neumayer  HH,
                                                                  Budde K. Increased incidence of angioedema with ACE
            66.  Franz  DN, Belousova  E, Sparagana S,  et al.  Efficacy   inhibitors in combination with mTOR inhibitors in kidney
               and safety of everolimus for subependymal giant cell
               astrocytomas associated with tuberous sclerosis complex   transplant recipients. Clin J Am Soc Nephrol. 2010;5(4):703-708.
               (EXIST-1): A multicentre, randomised, placebo-controlled      doi: 10.2215/CJN.07371009
               phase 3 trial [published correction appears in Lancet.   76.  Chandra  A,  Rao  NS,  Malhotra  KP,  Rastogi  M,  Khurana  R.
               2013;381(9861):116]. Lancet. 2013;381(9861):125-132.  Everolimus-associated acute kidney injury in patients with
               doi: 10.1016/S0140-6736(12)61134-9                 metastatic breast cancer. Indian J Nephrol. 2017;27(5):406-409.


            Volume 3 Issue 3 (2024)                         19                               doi: 10.36922/an.3568
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