Page 55 - AN-4-1

Advanced Neurology LLPS in neurodegenerative diseases

doi: 10.3389/fphys.2021.795757 differentially regulate synaptic plasticity and dendritic
development. Elife. 2020;9:e56273.
32. Milovanovic D, Rizzoli SO. Editorial: Protein phase
separation and aggregation in (Patho) physiology of doi: 10.7554/eLife.56273
neurons. Front Physiol. 2022;13:959570.
44. Patel A, Lee HO, Jawerth L, et al. A liquid-to-solid phase
doi: 10.3389/fphys.2022.959570 transition of the ALS protein FUS accelerated by disease
33. Liang M, Jin G, Xie X, et al. Oligomerized liprin-α promotes mutation. Cell. 2015;162(5):1066-1077.
phase separation of ELKS for compartmentalization of doi: 10.1016/j.cell.2015.07.047
presynaptic active zone proteins. Cell Rep. 2021;34(12):108901.
45. Mackenzie IR, Nicholson AM, Sarkar M, et al. TIA1 mutations
doi: 10.1016/j.celrep.2021.108901 in amyotrophic lateral sclerosis and frontotemporal dementia
promote phase separation and alter stress granule dynamics.
34. Milovanovic D, Wu Y, Bian X, De Camilli P. A liquid phase of
synapsin and lipid vesicles. Science. 2018;361(6402):604-607. Neuron. 2017;95(4):808-816.e9.
doi: 10.1126/science.aat5671 doi: 10.1016/j.neuron.2017.07.025
35. Wu X, Cai Q, Shen Z, et al. RIM and RIM-BP form presynaptic 46. Conicella AE, Zerze GH, Mittal J, Fawzi NL. ALS mutations
active-zone-like condensates via phase separation. Mol Cell. disrupt phase separation mediated by α-helical structure in
2019;73(5):971-984.e5. the TDP-43 low-complexity C-terminal domain. Structure.
2016;24(9):1537-1549.
doi: 10.1016/j.molcel.2018.12.007
doi: 10.1016/j.str.2016.07.007
36. Chen X, Wu X, Wu H, Zhang M. Phase separation at the
synapse. Nat Neurosci. 2020;23(3):301-310. 47. Murray DT, Kato M, Lin Y, et al. Structure of FUS protein
fibrils and its relevance to self-assembly and phase separation
doi: 10.1038/s41593-019-0579-9 of low-complexity domains. Cell. 2017;171(3):615-627.e16.
37. Zeng M, Chen X, Guan D, et al. Reconstituted postsynaptic doi: 10.1016/j.cell.2017.08.048
density as a molecular platform for understanding synapse
formation and plasticity. Cell. 2018;174(5):1172-1187.e16. 48. Solomon DA, Smikle R, Reid MJ, Mizielinska S. Altered
phase separation and cellular impact in C9orf72-Linked
doi: 10.1016/j.cell.2018.06.047 ALS/FTD. Front Cell Neurosci. 2021;15:664151.
38. Zeng M, Shang Y, Araki Y, Guo T, Huganir RL, Zhang M. doi: 10.3389/fncel.2021.664151
Phase transition in postsynaptic densities underlies
formation of synaptic complexes and synaptic plasticity. 49. Wang J, Choi JM, Holehouse AS, et al. A molecular grammar
Cell. 2016;166(5):1163-1175.e12. governing the driving forces for phase separation of prion-
like RNA binding proteins. Cell. 2018;174(3):688-699.e16.
doi: 10.1016/j.cell.2016.07.008
doi: 10.1016/j.cell.2018.06.006
39. Christensen NR, Pedersen CP, Sereikaite V, et al. Bidirectional
protein-protein interactions control liquid-liquid phase 50. Zhou J, Chuang Y, Redding-Ochoa J, et al. The autophagy
separation of PSD-95 and its interaction partners. iScience. adaptor TRIAD3A promotes tau fibrillation by nested phase
2022;25(2):103808. separation. Nat Cell Biol. 2024;26(8):1274-1286.
doi: 10.1016/j.isci.2022.103808 doi: 10.1038/s41556-024-01461-4
40. Letts VA, Felix R, Biddlecome GH, et al. The mouse stargazer 51. Beijer D, Kim HJ, Guo L, et al. Characterization of HNRNPA1
gene encodes a neuronal Ca2+-channel gamma subunit. Nat mutations defines diversity in pathogenic mechanisms and
Genet. 1998;19(4):340-347. clinical presentation. JCI Insight. 2021;6(14):e148363.
doi: 10.1038/1228 doi: 10.1172/jci.insight.148363
41. Zeng M, Díaz-Alonso J, Ye F, et al. Phase separation-mediated 52. Ryan VH, Perdikari TM, Naik MT, et al. Tyrosine
TARP/MAGUK complex condensation and AMPA receptor phosphorylation regulates hnRNPA2 granule protein
synaptic transmission. Neuron. 2019;104(3):529-543.e6. partitioning and reduces neurodegeneration. EMBO J.
2021;40(3):e105001.
doi: 10.1016/j.neuron.2019.08.001
doi: 10.15252/embj.2020105001
42. Araki Y, Zeng M, Zhang M, Huganir RL. Rapid dispersion
of SynGAP from synaptic spines triggers AMPA receptor 53. Yu H, Lu S, Gasior K, et al. HSP70 chaperones RNA-free
insertion and spine enlargement during LTP. Neuron. TDP-43 into anisotropic intranuclear liquid spherical shells.
2015;85(1):173-189. Science. 2021;371(6529):eabb4309.
doi: 10.1016/j.neuron.2014.12.023 doi: 10.1126/science.abb4309
43. Araki Y, Hong I, Gamache TR, et al. SynGAP isoforms 54. Scherer NM, Maurel C, Graus MS, et al. RNA-binding properties

Volume 4 Issue 1 (2025) 49 doi: 10.36922/an.4493