Page 43 - AN-4-2
P. 43
Advanced Neurology SARS-CoV-2 mechanisms of neurological impact
SARS pathogenesis. J Pathol. 2004;203(2):631‑637. doi: 10.18433/jpps31455
doi: 10.1002/path.1570 187. Villa C, Rivellini E, Lavitrano M, Combi R. Can SARS-CoV-2
infection exacerbate Alzheimer’s disease? An overview of
176. Zhao Y, Li W, Lukiw W. Ubiquity of the SARS‑CoV‑2 receptor shared risk factors and pathogenetic mechanisms. J Pers
ACE2 and upregulation in limbic regions of Alzheimer’s Med. 2022;12(1):29.
disease brain. Folia Neuropathol. 2021;59(3):232‑238.
doi: 10.3390/jpm12010029
doi: 10.5114/fn.2021.109495
188. Thakur A, Sharma V, Averbek S, et al. Immune landscape
177. Lindskog C, Mear L, Virhammar J, et al. Protein expression and redox imbalance during neurological disorders in
profile of ACE2 in the normal and COVID-19-affected COVID-19. Cell Death Dis. 2023;14(9):593.
human brain. J Proteome Res. 2022;21(9):2137‑2145.
doi: 10.1038/s41419-023-06102-6
doi: 10.1021/acs.jproteome.2c00184
189. Lim KH, Yang S, Kim SH, Joo JY. Elevation of ACE2 as a
178. Lukiw WJ, Pogue A, Hill JM. SARS‑CoV‑2 Infectivity SARS-CoV-2 entry receptor gene expression in Alzheimer’s
and neurological targets in the brain. Cell Mol Neurobiol. disease. J Infect. 2020;81(3):e33‑e34.
2022;42(1):217‑224.
doi: 10.1016/j.jinf.2020.06.072
doi: 10.1007/s10571-020-00947-7
190. Bland AR, Barraclough M, Trender WR, et al. Profiles of
179. Tyagi K, Rai P, Gautam A, et al. Neurological manifestations objective and subjective cognitive function in post‑COVID
of SARS-CoV-2: Complexity, mechanism and associated syndrome, COVID-19 recovered, and COVID-19 naive
disorders. Eur J Med Res. 2023;28(1):307. individuals. Sci Rep. 2024;14(1):13368.
doi: 10.1186/s40001-023-01293-2 doi: 10.1038/s41598-024-62050-x
180. Erickson MA, Rhea EM, Knopp RC, Banks WA. Interactions 191. Nouraeinejad A. The link between COVID‑19 and
of SARS-CoV-2 with the blood-brain barrier. Int J Mol Sci. Alzheimer disease through neuroinflammation. Clin Med
2021;22(5):2681. Res. 2023;21(3):119‑121.
doi: 10.3390/ijms22052681 doi: 10.3121/cmr.2023.1841
181. Burks SM, Rosas‑Hernandez H, Alejandro Ramirez‑Lee M, 192. Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation
Cuevas E, Talpos JC. Can SARS-CoV-2 infect the central in neurodegeneration development. Signal Transduct Target
nervous system via the olfactory bulb or the blood-brain Ther. 2023;8(1):267.
barrier? Brain Behav Immun. 2021;95:7‑14.
doi: 10.1038/s41392-023-01486-5
doi: 10.1016/j.bbi.2020.12.031
193. Kutzing MK, Luo V, Firestein BL. Protection from glutamate-
182. Miners S, Kehoe PG, Love S. Cognitive impact of induced excitotoxicity by memantine. Ann Biomed Eng.
COVID-19: Looking beyond the short term. Alzheimers Res 2012;40(5):1170‑1181.
Ther. 2020;12(1):170.
doi: 10.1007/s10439-011-0494-z
doi: 10.1186/s13195-020-00744-w
194. Muller T, Riederer P, Kuhn W. Aminoadamantanes: From
183. Qi F, Qian S, Zhang S, Zhang Z. Single cell RNA sequencing treatment of Parkinson’s and Alzheimer’s disease to symptom
of 13 human tissues identify cell types and receptors of amelioration of long COVID-19 syndrome? Expert Rev Clin
human coronaviruses. Biochem Biophys Res Commun. Pharmacol. 2023;16(2):101‑107.
2020;526(1):135‑140.
doi: 10.1080/17512433.2023.2176301
doi: 10.1016/j.bbrc.2020.03.044
195. Adingupu DD, Soroush A, Hansen A, Twomey R, Dunn JF.
184. Ashraf UM, Abokor AA, Edwards JM, et al. SARS-CoV-2, Brain hypoxia, neurocognitive impairment, and quality of life
ACE2 expression, and systemic organ invasion. Physiol in people post-COVID-19. J Neurol. 2023;270(7):3303‑3314.
Genomics. 2021;53(2):51‑60.
doi: 10.1007/s00415-023-11767-2
doi: 10.1152/physiolgenomics.00087.2020
196. Ortega MA, Fraile-Martinez O, Garcia-Montero C, et al.
185. Cheng H, Wang Y, Wang GQ. Organ‑protective effect of A general overview on the hyperbaric oxygen therapy:
angiotensin-converting enzyme 2 and its effect on the Applications, mechanisms and translational opportunities.
prognosis of COVID-19. J Med Virol. 2020;92(7):726‑730. Medicina (Kaunas). 2021;57(9):864.
doi: 10.1002/jmv.25785 doi: 10.3390/medicina57090864
186. Guney C, Akar F. Epithelial and endothelial expressions 197. Gottfried I, Schottlender N, Ashery U. Hyperbaric oxygen
of ACE2: SARS-CoV-2 entry routes. J Pharm Pharm Sci. treatment-from mechanisms to cognitive improvement.
2021;24:84‑93. Biomolecules. 2021;11(10):1520.
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