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Advanced Neurology SARS-CoV-2 mechanisms of neurological impact

CoV-2 affect neurodegenerative disorders? TLR2, a doi: 10.1007/s00701-016-3046-3
potential receptor for SARS-CoV-2 in the CNS. Exp Mol 123. Greene C, Hanley N, Reschke CR, et al. Microvascular
Med. 2022;54(4):447‑454. stabilization via blood-brain barrier regulation prevents
doi: 10.1038/s12276-022-00755-7 seizure activity. Nat Commun. 2022;13(1):2003.
113. 2023 Alzheimer’s disease facts and figures. Alzheimers doi: 10.1038/s41467-022-29657-y
Dement. 2023;19(4):1598‑1695. 124. Abdelhak A, Foschi M, Abu-Rumeileh S, et al. Blood GFAP
doi: 10.1002/alz.13016 as an emerging biomarker in brain and spinal cord disorders.
Nat Rev Neurol. 2022;18(3):158‑172.
114. Naughton SX, Raval U, Pasinetti GM. Potential novel role
of COVID-19 in Alzheimer’s disease and preventative doi: 10.1038/s41582-021-00616-3
mitigation strategies. J Alzheimers Dis. 2020;76(1):21‑25. 125. Peluso MJ, Sans HM, Forman CA, et al. Plasma markers of
doi: 10.3233/JAD-200537 neurologic injury and inflammation in people with self‑reported
neurologic postacute sequelae of SARS-CoV-2 infection.
115. Jiang Y, Neal J, Sompol P, et al. Parallel electrophysiological Neurol Neuroimmunol Neuroinflamm. 2022;9(5):e200003.
abnormalities due to COVID-19 infection and to
Alzheimer’s disease and related dementia. Alzheimers doi: 10.1212/NXI.0000000000200003
Dement. 2024;20:7296‑7319. 126. McCarthy MJ. Circadian rhythm disruption in myalgic
doi: 10.1002/alz.14089 encephalomyelitis/chronic fatigue syndrome: Implications
for the post-acute sequelae of COVID-19. Brain Behav
116. Natale NR, Lukens JR, Petri WA Jr. The nervous system Immun Health. 2022;20:100412.
during COVID-19: Caught in the crossfire. Immunol Rev.
2022;311(1):90‑111. doi: 10.1016/j.bbih.2022.100412
doi: 10.1111/imr.13114 127. Montoya JG, Holmes TH, Anderson JN, et al. Cytokine
signature associated with disease severity in chronic
117. Rodriguez-Morales J, Guartazaca-Guerrero S, Rizo- fatigue syndrome patients. Proc Natl Acad Sci U S A.
Tellez SA, et al. Blood-brain barrier damage is pivotal for 2017;114(34):E7150‑E7158.
SARS-CoV-2 infection to the central nervous system. Exp
Neurobiol. 2022;31(4):270‑276. doi: 10.1073/pnas.1710519114
doi: 10.5607/en21049 128. Savarraj J, Park ES, Colpo GD, et al. Brain injury,
endothelial injury and inflammatory markers are elevated
118. Knox EG, Aburto MR, Clarke G, Cryan JF, O’Driscoll CM. and express sex-specific alterations after COVID-19.
The blood-brain barrier in aging and neurodegeneration. J Neuroinflammation. 2021;18(1):277.
Mol Psychiatry. 2022;27(6):2659‑2673.
doi: 10.1186/s12974-021-02323-8
doi: 10.1038/s41380-022-01511-z
129. Wenzel J, Lampe J, Muller‑Fielitz H, et al. The SARS-CoV-2
119. Lee MH, Perl DP, Steiner J, et al. Neurovascular injury with main protease M(pro) causes microvascular brain pathology
complement activation and inflammation in COVID-19. by cleaving NEMO in brain endothelial cells. Nat Neurosci.
Brain. 2022;145(7):2555‑2568. 2021;24(11):1522‑1533.
doi: 10.1093/brain/awac151 doi: 10.1038/s41593-021-00926-1
120. Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. 130. Taquet M, Skorniewska Z, Hampshire A, et al. Acute
Neurological manifestations of COVID-19 and other blood biomarker profiles predict cognitive deficits 6 and
coronavirus infections: A systematic review. Clin Neurol 12 months after COVID-19 hospitalization. Nat Med.
Neurosurg. 2020;194:105921. 2023;29(10):2498‑2508.
doi: 10.1016/j.clineuro.2020.105921 doi: 10.1038/s41591-023-02525-y
121. Greene C, Connolly R, Brennan D, et al. Blood-brain 131. DeOre BJ, Tran KA, Andrews AM, Ramirez SH, Galie PA.
barrier disruption and sustained systemic inflammation SARS-CoV-2 spike protein disrupts blood-brain barrier
in individuals with long COVID-associated cognitive integrity via RhoA activation. J Neuroimmune Pharmacol.
impairment. Nat Neurosci. 2024;27(3):421‑432. 2021;16(4):722‑728.
doi: 10.1038/s41593-024-01576-9 doi: 10.1007/s11481-021-10029-0
122. Thelin EP, Nelson DW, Bellander BM. A review of the 132. Buzhdygan TP, DeOre BJ, Baldwin-Leclair A, et al. The
clinical utility of serum S100B protein levels in the SARS-CoV-2 spike protein alters barrier function in 2D
assessment of traumatic brain injury. Acta Neurochir (Wien). static and 3D microfluidic in-vitro models of the human
2017;159(2):209‑225. blood-brain barrier. Neurobiol Dis. 2020;146:105131.

Volume 4 Issue 2 (2025) 34 doi: 10.36922/an.4909