Page 82 - AN-4-2
P. 82

Advanced Neurology                                             Brain bioavailability of targeted protein degraders



               doi: 10.3390/antib12030043                         in cortical blood vessels in mice. Am J Physiol Heart Circ
                                                                  Physiol. 2012;302(7):H1367-H1377.
            100. Jones AR, Shusta EV. Blood-brain barrier transport
               of therapeutics via receptor-mediation. Pharm Res.      doi: 10.1152/ajpheart.00417.2011
               2007;24(9):1759-1771.
                                                               111. Helms HCC, Kristensen M, Saaby L, Fricker G, Brodin B.
               doi: 10.1007/s11095-007-9379-0                     Drug delivery strategies to overcome the blood-brain barrier
            101. Yu YJ, Watts RJ. Developing therapeutic antibodies   (BBB). Handb Exp Pharmacol. 2022;273:151-183.
               for  neurodegenerative  disease.  Neurotherapeutics.      doi: 10.1007/164_2020_403
               2013;10(3):459-472.
                                                               112. Sweeney PW, Walker-Samuel S, Shipley RJ. Insights
               doi: 10.1007/s13311-013-0187-4                     into cerebral haemodynamics and oxygenation utilising
            102. Fishman JB, Rubin JB, Handrahan JV, Connor JR, Fine RE.   in vivo mural cell imaging and mathematical modelling. Sci
               Receptor-mediated transcytosis of transferrin across the   Rep. 2018;8(1):1373.
               blood-brain barrier. J Neurosci Res. 1987;18(2):299-304.     doi: 10.1038/s41598-017-19086-z
               doi: 10.1002/jnr.490180206                      113. de Lange ECM. The physiological characteristics and
            103. Lichota J, Skjørringe T, Thomsen  LB, Moos T.    transcytosis mechanisms of the blood-brain barrier (BBB).
               Macromolecular drug transport into the brain using targeted   Curr Pharm Biotechnol. 2012;13(12):2319-2327.
               therapy. J Neurochem. 2010;113(1):1-13.            doi: 10.2174/138920112803341860
               doi: 10.1111/j.1471-4159.2009.06544.x           114. Bickel U, Yoshikawa T, Pardridge WM. Delivery of peptides
            104. van  Gelder  W, Huijskes-Heins  MI,  van Dijk  JP,  Cleton-  and  proteins  through  the  blood-brain  barrier.  Adv  Drug
               Soeteman  MI,  van  Eijk  HG.  Quantification  of  different   Deliv Rev. 2001;46(1-3):247-279.
               transferrin receptor pools in primary cultures of porcine      doi: 10.1016/s0169-409x(00)00139-3
               blood-brain  barrier  endothelial  cells.  J  Neurochem.
               1995;64(6):2708-2715.                           115. Thöle M, Nobmann S, Huwyler J, Bartmann A, Fricker G.
                                                                  Uptake of cationized albumin coupled liposomes by cultured
               doi: 10.1046/j.1471-4159.1995.64062708.x
                                                                  porcine brain microvessel endothelial cells and intact brain
            105. Johnsen KB, Burkhart A, Thomsen LB, Andresen TL,   capillaries. J Drug Target. 2002;10(4):337-344.
               Moos T. Targeting the transferrin receptor for brain drug      doi: 10.1080/10611860290031840
               delivery. Prog Neurobiol. 2019;181:101665.
                                                               116. Patching SG. Glucose transporters at the blood-brain
               doi: 10.1016/j.pneurobio.2019.101665
                                                                  barrier: Function, regulation and gateways for drug delivery.
            106. Niewoehner J, Bohrmann B, Collin L, et al. Increased brain   Mol Neurobiol. 2017;54(2):1046-1077.
               penetration and potency of a therapeutic antibody using a
               monovalent molecular shuttle. Neuron. 2014;81(1):49-60.     doi: 10.1007/s12035-015-9672-6.
               doi: 10.1016/j.neuron.2013.10.061               117. Nadal  A,  Fuentes  E,  Pastor  J,  McNaughton  PA.  Plasma
                                                                  albumin  is  a  potent  trigger  of  calcium  signals  and
            107. Yu YJ,  Zhang Y, Kenrick  M,  et al. Boosting brain uptake   DNA synthesis in astrocytes.  Proc Natl Acad Sci USA.
               of a therapeutic antibody by reducing its affinity for a   1995;92(5):1426-1430.
               transcytosis target. Sci Transl Med. 2011;3(84):84ra44.
                                                                  doi: 10.1073/pnas.92.5.1426
               doi: 10.1126/scitranslmed.3002230
                                                               118. Dvorak AM, Feng D. The vesiculo-vacuolar organelle
            108. Ullman JC, Arguello A, Getz JA,  et al. Brain delivery   (VVO). A  new endothelial cell permeability organelle.
               and activity of a lysosomal enzyme using a blood-  J Histochem Cytochem. 2001;49(4):419-432.
               brain barrier transport vehicle in mice.  Sci Transl Med.
               2020;12(545):eaay1163.                             doi: 10.1177/002215540104900401
               doi: 10.1126/scitranslmed.aay1163               119. Komarova Y, Malik AB. Regulation of endothelial
                                                                  permeability via paracellular and transcellular transport
            109. Kariolis MS, Wells RC, Getz JA,  et al. Brain delivery of   pathways. Annu Rev Physiol. 2010;72:463-493.
               therapeutic proteins using an Fc fragment blood-brain
               barrier transport vehicle in mice and monkeys. Sci Transl      doi: 10.1146/annurev-physiol-021909-135833
               Med. 2020;12(545):eaay1359.                     120. Schnitzer JE, Oh P. Albondin-mediated capillary
               doi: 10.1126/scitranslmed.aay1359                  permeability to albumin. Differential role of receptors in
                                                                  endothelial transcytosis and endocytosis of native and
            110. Santisakultarm  TP,  Cornelius  NR,  Nishimura  N,  et al.
               In-vivo two-photon excited fluorescence microscopy reveals   modified albumins. J Biol Chem. 1994;269(8):6072-6082.
               cardiac-and respiration-dependent pulsatile blood flow      doi: 10.1016/S0021-9258(17)37571-3


            Volume 4 Issue 2 (2025)                         76                               doi: 10.36922/an.5140
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