Page 78 - AN-4-2

Advanced Neurology Brain bioavailability of targeted protein degraders

doi: 10.1016/j.neuroimage.2007.10.054 trypanosome infections of the nervous system: Parasite
entry and effects on sleep and synaptic functions. Prog
10. Meyer EP, Ulmann-Schuler A, Staufenbiel M, Krucker T.
Altered morphology and 3D architecture of brain vasculature Neurobiol. 2010;91(2):152-171.
in a mouse model for Alzheimer’s disease. Proc Natl Acad Sci doi: 10.1016/j.pneurobio.2009.12.001
USA. 2008;105(9):3587-3592. 22. Engelhardt B, Vajkoczy P, Weller RO. The movers and
doi: 10.1073/pnas.0709788105 shapers in immune privilege of the CNS. Nat Immunol.
2017;18:123-131.
11. Wong AD, Ye M, Levy AF, Rothstein JD, Bergles DE,
Searson PC. The blood-brain barrier: An engineering doi: 10.1038/ni.3666
perspective. Front Neuroeng. 2013;6:7. 23. Kucharz K, Kristensen K, Bendix Johnsen K, et al. Post-
doi: 10.3389/fneng.2013.00007 capillary venules are the key locus for transcytosis-mediated
brain delivery of therapeutic nanoparticles. Nat Commun.
12. Joan Abbott N, Patabendige AAK, Dolman DEM, Yusof SR, 2021;12(1):4121.
Begley DJ. Structure and function of the blood-brain barrier.
Neurobiol Dis. 2010;37(1):13-25. doi: 10.1038/s41467-021-24323-1
doi: 10.1016/j.nbd.2009.07.030 24. Macdonald JA, Murugesan N, Pachter JS. Endothelial
cell heterogeneity of blood-brain barrier gene expression
13. DeStefano JG, Jamieson JJ, Linville RM, Searson PC. along the cerebral microvasculature. J Neurosci Res.
Benchmarking in vitro tissue-engineered blood-brain 2010;88(7):1457-1474.
barrier models. Fluids Barriers CNS. 2018;15(1):32.
doi: 10.1002/jnr.22316
doi: 10.1186/s12987-018-0117-2
25. Mehta A, Desai A, Rudd D, et al. Bio-mimicking brain
14. Palade GE, Simionescu M, Simionescu N. Structural aspects vasculature to investigate the role of heterogeneous shear
of the permeability of the microvascular endothelium. Acta stress in regulating barrier integrity. Adv Biol (Weinh).
Physiol Scand Suppl. 1979;463:11-32. 2022;6(12):e2200152.
15. Nacer A, Movila A, Baer K, Mikolajczak SA, Kappe SHI, doi: 10.1002/adbi.202200152
Frevert U. Neuroimmunological blood brain barrier
opening in experimental cerebral malaria. PLoS Pathog. 26. Partyka PP, Godsey GA, Galie JR, et al. Mechanical stress
2012;8(10):e1002982. regulates transport in a compliant 3D model of the blood-
brain barrier. Biomaterials. 2017;115:30-39.
doi: 10.1371/journal.ppat.1002982
doi: 10.1016/j.biomaterials.2016.11.012
16. Kienast Y, von Baumgarten L, Fuhrmann M, et al. Real-
time imaging reveals the single steps of brain metastasis 27. Simionescu M, Simionescu N, Palade GE. Segmental
formation. Nat Med. 2010;16(1):116-122. differentiations of cell junctions in the vascular endothelium.
The microvasculature. J Cell Biol. 1975;67(3):863-885.
doi: 10.1038/nm.2072
doi: 10.1083/jcb.67.3.863
17. Larochelle C, Alvarez JI, Prat A. How do immune cells
overcome the blood-brain barrier in multiple sclerosis? 28. Cecchelli R, Berezowski V, Lundquist S, et al. Modelling of
FEBS Lett. 2011;585(23):3770-3780. the blood-brain barrier in drug discovery and development.
Nat Rev Drug Discov. 2007;6:650-661.
doi: 10.1016/j.febslet.2011.04.066
doi: 10.1038/nrd2368
18. Holman DW, Klein RS, Ransohoff RM. The blood-brain
barrier, chemokines and multiple sclerosis. Biochim Biophys 29. Nag S, Begley David J. Blood-brain barrier, exchange
Acta. 2011;1812(2):220-230. of metabolites and gases. In: Pathology and Genetics
Cerebrovascular Diseases. Basel: ISN Neuropath Press; 2005.
doi: 10.1016/j.bbadis.2010.07.019 p. 22-29.
19. Takeshita Y, Ransohoff RM. Inflammatory cell trafficking 30. Joan Abbott N. Dynamics of CNS barriers: Evolution,
across the blood-brain barrier: Chemokine regulation and differentiation, and modulation. Cell Mol Neurobiol.
in vitro models. Immunol Rev. 2012;248:228-239. 2005;25(1):5-23.
doi: 10.1111/j.1600-065X.2012.01127.x doi: 10.1007/s10571-004-1374-y
20. Owens T, Bechmann I, Engelhardt B. Perivascular spaces 31. Arvanitis CD, Ferraro GB, Jain RK. The blood-brain barrier
and the two steps to neuroinflammation. J Neuropathol Exp and blood-tumor barrier in brain tumours and metastases.
Neurol. 2008;67(12):1113-1121. Nat Rev Cancer. 2020;20(1):26-41.
doi: 10.1097/NEN.0b013e31818f9ca8 doi: 10.1038/s41568-019-0205-x
21. Kristensson K, Nygård M, Bertini G, Bentivoglio M. African 32. Jena L, McErlean E, McCarthy H. Delivery across the blood-

Volume 4 Issue 2 (2025) 72 doi: 10.36922/an.5140