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Advanced Neurology                                                     TBI and depression by veteran status




            Table 1. Sample characteristics stratified by veteran status and depression
            Variable                   Whole sample                Veteran                   Non‑veteran
                                 Depression   No depression   Depression   No depression   Depression   No depression
                                   (n, %)       (n, %)       (n, %)       (n, %)        (n, %)       (n, %)
            TBI history
             No                   1180 (5.4)  20602 (94.6)  93 (12.9)     77 (4.6)     1098 (5.5)   18890 (94.5)
             Yes                  564 (10.2)   4941 (89.8)  629 (87.1)   1596 (95.4)   469 (9.9)    4290 (90.1)
             Age, mean±SD        51.84±18.86  53.22±18.52  59.06±16.53  64.80±16.13   51.05±18.94   52.17±18.36
            Sex
             Male                 848 (6.5)   12239 (93.5)  177 (7.9)    2054 (92.1)   656 (6.2)    9986 (93.8)
             Female               1139 (7.3)  14392 (92.7)   26 (9.2)    256 (90.8)    1092 (7.3)   13906 (92.7)
            Race and ethnicity
             White                1289 (6.8)  17719 (93.2)  145 (7.3)    1836 (92.7)   1127 (6.7)   15658 (93.3)
             African American      273 (9)     2766 (91)    31 (11.5)    239 (88.5)    233 (8.7)    2448 (91.3)
             Hispanic             282 (6.6)    3991 (93.4)   17 (9.8)    156 (90.2)    259 (6.5)    3753 (93.5)
             Other                144 (6.3)    2159 (93.7)  10 (11.2)    79 (88.8)     130 (6.0)    2037 (94.0)
            Education status
             Below high school    247 (10.2)   2179 (89.8)   6 (7.3)     85 (93.4)     235 (10.3)   2052 (89.7)
             12  grade/GED/       982 (8.6)   10489 (91.4)  121 (10.7)   1005 (89.3)   841 (8.3)    9294 (91.7)
               th
             Equivalent
             Associate degree      259 (7)     3445 (93)     33 (8.2)    369 (91.8)    223 (6.9)    3030 (93.1)
             Bachelor’s degree    323 (4.9)    6298 (95.1)   29 (5.6)    489 (94.4)    291 (4.8)    5722 (95.2)
             Postgraduate degree  164 (3.8)    4111 (96.2)   13 (3.5)    358 (96.5)    148 (3.8)    3698 (96.2)
            General health status
             Excellent            137 (2.3)    5732 (97.7)   13 (3.7)    342 (96.3)    121 (2.2)    5288 (97.8)
             Very good            361 (3.7)    9302 (96.3)   26 (3.4)    737 (96.6)    328 (3.7)    8436 (96.3)
             Good                 568 (6.7)    7876 (93.3)   51 (6.1)    784 (93.9)    507 (6.8)    6964 (93.2)
             Fair                 543 (15.2)   3041 (84.8)  57 (13.8)    356 (86.2)    476 (15.3)   2632 (84.7)
             Poor                 378 (36.1)   670 (63.9)   56 (38.9)    88 (61.1)     316 (35.8)   566 (64.2)
             Hypertension         910 (8.4)    9866 (91.6)  121 (8.9)    1232 (91.1)   771 (8.3)    8519 (91.7)
             Cardiovascular disease  190 (10.7)  1588 (89.3)  40 (12)    293 (88)      147 (10.3)   1280 (89.7)
             Cancer                258 (7)     3407 (93)     35 (6.3)    523 (93.7)    221 (7.2)    2839 (92.8)
             Diabetes             354 (11.1)   2832 (88.9)  49 (11.1)    393 (88.9)    299 (11.1)   2404 (88.9)
            Abbreviations: SD: Standard deviation; TBI: Traumatic brain injury.

            deprivation, exertion, and nutritional deficiency, often   issue that may have debilitating effects both on the healthcare
            develop psychological disorders later in their lives.  This   system and the personal lives of the affected individuals. This
                                                     19
            is often compounded by TBI suffered by veterans on   requires urgent intervention from public health organizations
            active duty as many of them suffer from post-traumatic   both among the general population and veterans. Most of
            stress disorder, cognitive deficits, and suicidal thoughts.    the cases of depression among veterans are resolved after
                                                         20
            Affected persons might suffer from other symptoms   psychotherapy and pharmacological management. Cognitive
            alongside  depression including chronic  pain  and loss   behavioral therapy and interpersonal  therapy  help people
            of employment.  In addition, an increased incidence of   manage negative thoughts and suicidal ideation, as well as
                         21
            brain cancer was reported among veterans suffering from   help developing coping skills.  Patients unresponsive to
                                                                                       23
            moderate-to-severe head injury. 22                 psychological therapy are often treated with antidepressants
              The higher odds of depression and incidence of TBIs   and mood stabilizers.  At present, available antidepressants
                                                                                24
            reported among veterans contribute to a major public health   are highly effective, reducing symptoms by more than 50%


            Volume 4 Issue 3 (2025)                         73                           doi: 10.36922/AN025050008
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