Page 9 - ARNM-1-1

Advances in Radiotherapy &

Nuclear Medicine

REVIEW ARTICLE
Image-guided permanent I-125 seed

implantation for refractory head-and-neck
carcinoma in China: A comprehensive review of

contemporary technical and clinical aspects

2
1
1
1
1†
Suqing Tian , Bin Qiu , Ping Jiang , Yuliang Jiang , Zhe Ji , Mingwei Huang ,
1†
1
3
Gordon L. Grado , and Junjie Wang *
1 Department of Radiation Oncology, Peking University Third Hospital, Beijing, China
2 Department of Head and Neck, Peking University Stomatology Hospital, Beijing, China
3 Southwest Oncology Centers, Scottsdale, Arizona, USA
Abstract
Permanent I-125 seed implantation is one of the most commonly used brachytherapy
(BT) forms, potentially applicable to almost any solid tumor as a standalone anti-
tumor therapy or in combination with external beam radiotherapy (EBRT). The main
advantage of I-125 seed implantation BT is its ability to deliver a high radiation dose
within target volumes while maintaining a sharp dose drop-off profile, thereby
† These authors contributed equally protecting adjacent normal tissue. The clinical use of I-125 seed implantation in
to this work. China has significantly increased in the past decades due to the application of an
*Corresponding author: image-guided BT treatment planning system with reverse optimization capabilities
Junjie Wang and 3D printing individual template (3D-PIT) assistance. Computed tomography-
(junjiewang_edu@sina.cn)
guided I-125 seed implantation became a widely common modality of BT and has
Citation: Tian S, Qiu B, been used in many clinical settings for a variety of refractory cancer in China since
Jiang P, et al., 2023, Image- 2002. The application has been expanded significantly not only for prostate cancer
guided permanent I-125 seed
implantation for refractory head- as monotherapy but also in combination with EBRT for the salvage treatment for
and-neck carcinoma in China: refractory/recurrent head-and-neck carcinoma (HNC). With the assistance of 3D-PIT,
A comprehensive review of since 2015, the quality control of I-125 seed implantation has been significantly
contemporary technical and clinical
aspects. Adv Radiother Nucl Med. adapted with high precision and real-time dose optimization. This review aims to
https://doi.org/10.36922/arnm.0907 summarize the developments and status of 3D-PIT-based I-125 seed implantation BT
Received: May 5, 2023 for the treatment of refractory HNC and standardized workflow in China.
Accepted: June 26, 2023
Keywords: Low-dose-rate; I-125 seed implantation; Refractory head-and-neck carcinoma;
Published Online: July 7, 2023
3D printed templates; Brachytherapy
Copyright: © 2023 Author(s).
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, 1. Introduction
and reproduction in any medium,
provided the original work is Concurrent chemoradiotherapy was the standard care for unresectable head-and-neck
properly cited. carcinoma (HNC) or as a salvage therapy for residual/recurrent disease after surgery.
Publisher’s Note: AccScience With the technological advances in external beam radiotherapy (EBRT), including
Publishing remains neutral with intensity-modulated radiotherapy, volume-modulated arc therapy, and image-guided
regard to jurisdictional claims in
published maps and institutional radiotherapy (IGRT), the prognosis of HNC has been dramatically improved in the
[1]
affiliations. past decade . Local and/or regional control (LC/RC) of HNC was the most significant

Volume 1 Issue 1 (2023) 1 https://doi.org/10.36922/arnm.0907