Page 31 - ARNM-1-2

Advances in Radiotherapy
& Nuclear Medicine FAP-targeted RLT in cancer

115: 695–702. https://doi.org/10.2967/jnumed.119.239731
https://doi.org/10.1093/jnci/djad040 13. Ballal S, Yadav MP, Kramer V, et al., 2021, A theranostic
approach of [ Ga]Ga-DOTA.SA.FAPi PET/CT-guided [177 Lu ]
68
2. Paskeh MDA, Entezari M, Mirzaei S, et al., 2022, Emerging
role of exosomes in cancer progression and tumor Lu-DOTA.SA.FAPi radionuclide therapy in an end-stage
microenvironment remodeling. J Hematol Oncol, 15: 83. breast cancer patient: New frontier in targeted radionuclide
therapy. Eur J Nucl Med Mol Imaging, 48: 942–944.
https://doi.org/10.1186/s13045-022-01305-4
https://doi.org/10.1007/s00259-020-04990-w
3. Morad G, Helmink BA, Sharma P, et al., 2021, Hallmarks
of response, resistance, and toxicity to immune checkpoint 14. Ohlund D, Elyada E, Tuveson D, 2014, Fibroblast
blockade. Cell, 184: 5309–5337. heterogeneity in the cancer wound. J Exp Med, 211:
1503–1523.
https://doi.org/10.1016/j.cell.2021.09.020
https://doi.org/10.1084/jem.20140692
4. Morris ZS, Wang AZ, Knox SJ, 2021, The radiobiology of
radiopharmaceuticals. Semin Radiat Oncol, 31: 20–27. 15. Mer AS, Ba-Alawi W, Smirnov P, et al., 2019, Integrative
pharmacogenomics analysis of patient-derived xenografts.
https://doi.org/10.1016/j.semradonc.2020.07.002 Cancer Res, 79: 4539–4550.
5. Langbein T, Weber WA, Eiber M, 2019, Future of https://doi.org/10.1158/0008-5472.CAN-19-0349
theranostics: An outlook on precision oncology in nuclear
medicine. J Nucl Med, 60: 13S–19S. 16. Ozdemir BC, Pentcheva-Hoang T, Carstens JL, et al., 2014,
Depletion of carcinoma-associated fibroblasts and fibrosis
https://doi.org/10.2967/jnumed.118.220566 induces immunosuppression and accelerates pancreas
cancer with reduced survival. Cancer Cell, 25: 719–734.
6. Fallah J, Agrawal S, Gittleman H, et al., 2023, FDA approval
summary: Lutetium Lu 177 vipivotide tetraxetan for patients https://doi.org/10.1016/j.ccr.2014.04.005
with metastatic castration-resistant prostate cancer. Clin
Cancer Res, 29: 1651–1657. 17. Rettig WJ, Su SL, Fortunato SR, et al., 1994, Fibroblast
activation protein: Purification, epitope mapping and
https://doi.org/10.1158/1078-0432.CCR-22-2875 induction by growth factors. Int J Cancer, 58: 385–392.
7. Chen X, Song E, 2019, Turning foes to friends: Targeting https://doi.org/10.1002/ijc.2910580314
cancer-associated fibroblasts. Nat Rev Drug Discov, 18. Zhao L, Chen J, Pang Y, et al., 2022, Fibroblast activation
18: 99–115.
protein-based theranostics in cancer research: A state-of-
https://doi.org/10.1038/s41573-018-0004-1 the-art review. Theranostics, 12: 1557–1569.
8. Hamson EJ, Keane FM, Tholen S, et al., 2014, Understanding https://doi.org/10.7150/thno.69475
fibroblast activation protein (FAP): Substrates, activities,
expression and targeting for cancer therapy. Proteomics Clin 19. Ora M, Soni N, Nazar AH, et al., 2023, Fibroblast activation
Appl, 8: 454–463. protein inhibitor-based radionuclide therapies: Current
status and future directions. J Nucl Med, 64: 1001–1008.
https://doi.org/10.1002/prca.201300095
https://doi.org/10.2967/jnumed.123.265594
68
9. Kratochwil C, Flechsig P, Lindner T, et al., 2019, Ga-FAPI 20. Ostermann E, Garin-Chesa P, Heider KH, et al., 2008,
PET/CT: Tracer uptake in 28 different kinds of cancer. J Nucl Effective immunoconjugate therapy in cancer models
Med, 60: 801–805.
targeting a serine protease of tumor fibroblasts. Clin Cancer
https://doi.org/10.2967/jnumed.119.227967 Res, 14: 4584–4592.
10. Chen H, Pang Y, Wu J, et al., 2020, Comparison of [ Ga] https://doi.org/10.1158/1078-0432.CCR-07-5211
68
Ga-DOTA-FAPI-04 and [ F] FDG PET/CT for the diagnosis 21. Duperret EK, Trautz A, Ammons D, et al., 2018, Alteration
18
of primary and metastatic lesions in patients with various of the tumor stroma using a consensus DNA vaccine
types of cancer. Eur J Nucl Med Mol Imaging, 47: 1820–1832.
targeting fibroblast activation protein (FAP) synergizes
https://doi.org/10.1007/s00259-020-04769-z with antitumor vaccine therapy in mice. Clin Cancer Res,
24: 1190–11201.
11. Lindner T, Loktev A, Altmann A, et al., 2018, Development
of quinoline-based theranostic ligands for the targeting of https://doi.org/10.1158/1078-0432.CCR-17-2033
fibroblast activation protein. J Nucl Med, 59: 1415–1422.
22. Gunderson AJ, Yamazaki T, McCarty K, et al., 2019,
https://doi.org/10.2967/jnumed.118.210443 Blockade of fibroblast activation protein in combination
with radiation treatment in murine models of pancreatic
12. Lindner T, Altmann A, Kramer S, et al., 2020, Design and
development of 99m Tc-labeled FAPI tracers for SPECT adenocarcinoma. PLoS One, 14: e0211117.
imaging and Re therapy. J Nucl Med, 61: 1507–1513. https://doi.org/10.1371/journal.pone.0211117
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