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Advances in Radiotherapy
& Nuclear Medicine Single-channel applicators for cervical cancer

Table 4. Patients and disease characteristics at baseline ready for treatment and comparison of toxicity between SCA and FAS
Characteristic SCA (n=19) FAS (n=22) P‑value
Age (years) 0.863
Range 41–65 36–69
Median 51 53
Pathology (n [%]) 0.861
Squamous cell carcinoma 16 (84.21) 20 (90.91)
Adenocarcinoma 3 (15.79) 2 (9.09)
Staging (n [%]) 0.426
IIA 5 (26.32) 2 (9.09)
IIB 10 (52.63) 16 (72.73)
IIIA 3 (15.79) 2 (9.09)
IIIB 1 (5.26) 2 (9.09)
ECOG score (n [%]) 0.563
0 8 (42.11) 12 (54.55)
1 10 (52.63) 8 (36.36)
2 1 (5.26) 2 (9.09)
Acute toxicity (n [%]) B R B R B 0.689 R 0.344
a
0 11 (57.89) 8 (42.11) 14 (63.64) 14 (63.64)
1 7 (36.84) 9 (47.37) 5 (22.73) 6 (27.27)
2 1 (5.26) 2 (10.53) 2 (9.09) 2 (9.09)
3 1 (4.55)
b
Late injury (n [%]) B R B R B 0.860 R 0.850
0 14 (73.68) 15 (78.95) 15 (68.18) 14 (63.64)
1 4 (21.05) 3 (15.79) 6 (27.27) 5 (22.73)
2 1 (5.26) 1 (5.26) 1 (4.55) 2 (9.09)
3 1 (4.55)
Notes: B represents bladder, and R represents rectum. Acute toxicity means toxicity to the bladder and rectum over the course of treatment or within
a
3 months post-treatment (F-test-based method). Late injury means injury to the bladder and rectum after 3 months post-treatment (F-test-based
b
method).
Abbreviations: FAS: Fletcher applicator set; SCA: Single-channel applicator.
applications. Based on our study, irradiation to point A, Funding
point B, and point R, was equal between the SCA and FAS,
showing no significant differences (P > 0.05) in both acute This work was supported by grants from the Supported
and late toxic effects during follow-up. Project of Science and Technology Department of Sichuan
Province (Z1443) and the Affiliated Hospital of Southwest
5. Conclusions Medical University (14004).
We found that the SCA was superior to the FAS on the Conflict of interest
grounds of its more simplified procedure of brachytherapy.
Nevertheless, despite the promising potential of the SCA, The authors declare no conflicts of interest.
further prospective validation studies are needed before
considering it as a possible alternative for those unwilling Author contributions
to undergo brachytherapy using the FAS. Conceptualization: Jing-Bo Wu
Investigation: Hao-Wen Pang, Xiang-Xiang Shi
Acknowledgments Writing – original draft: Ren-Jin Chen, Lei Yang

None. Writing – review & drafting: Sheng Lin

Volume 1 Issue 2 (2023) 6 https://doi.org/10.36922/arnm.0322