Page 43 - ARNM-1-2

Advances in Radiotherapy &

Nuclear Medicine

ORIGINAL RESEARCH ARTICLE
Unveiling the relationship between the SUVmax

of F-FDG PET/CT and patient and tumor
18
characteristics

2
1
Nishant Lohia , Sirshendu Ghosh , Sankalp Singh *, Indranil Sinha ,
3
1
Abhishek Mahato , Dharmesh Paliwal , and Gaurav Trivedi 1
3
3
1 Department of Radiation Oncology, Malignant Disease Treatment Centre, Command Hospital
(Central Command), Lucknow, Uttar Pradesh, India
2 Command Dental Centre, Lucknow, Uttar Pradesh, India
3 Department of Nuclear Medicine, Command Hospital (Central Command), Lucknow, Uttar Pradesh, India

Abstract

18 F-fluoro-2-deoxyglucose (FDG)-based positron emission tomography (PET)/computed
tomography (CT) is an indispensable tool in modern oncology, extensively used for
diagnosing and staging various cancers. The maximum standardized uptake value
(SUV ) of FDG helps identify the most metabolically active areas of disease. In
max
this analytical cross-sectional study performed between January and December
2019, we compared SUV max for different cancer types and determined the effect of
demographic, pathological, and clinical variables on SUV max . The study included 117
newly diagnosed cancer patients who underwent FDG PET/CT before treatment. Data
on descriptive variables, including age, gender, stage, histopathological diagnosis,
and tumor differentiation grade, were collected for each patient. Correlation analysis
*Corresponding author:
Sankalp Singh of these variables with SUV max in FDG PET/CT was performed using Spearmen’s test
(oncodoctor81@gmail.com) and a forward stepwise regression model. A total of 117 patients (63 males and
54 females) with a median age of 61 years (range: 21 – 90) were included in this
Citation: Lohia N, Ghosh S,
Singh S, et al., 2024, Unveiling the study. Histopathological diagnoses revealed squamous cell carcinoma (n = 71%),
relationship between the SUVmax adenocarcinoma (n = 24%), and small cell cancer (n = 5%). The SUV of the
max
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of F-FDG PET/CT and patient primary tumor was positively correlated with histology (P < 0.05), with the highest
and tumor characteristics. Adv
Radiother Nucl Med, 1(2): 2032. SUV max observed in squamous cell carcinomas. In conclusion, SUV max was positively
https://doi.org/10.36922/arnm.2032 correlated with histology, while no association was detected with the patient’s age
Received: October 13, 2023 and gender, as well as the stage, organ, site, or grade of the tumors. However, we
recommend a larger and more homogenous study sample to further investigate
Accepted: January 5, 2024
any clinically relevant relationship between the SUV max and various disease factors in
Published Online: January 10, 2024 diverse patient populations.
Copyright: © 2024 Author(s).
This is an Open-Access article
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distributed under the terms of the Keywords: F-fluoro-2-deoxyglucose; Maximum standardized uptake value;
Creative Commons Attribution Positron emission tomography/computed tomography; Cancer; Histopathology;
License, permitting distribution, Squamous cell carcinoma
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional Cancer is one of the leading causes of death worldwide. Its treatment requires
affiliations. multimodality care, commencing with early diagnosis, accurate staging, and a

Volume 1 Issue 2 (2024) 1 https://doi.org/10.36922/arnm.2032