Page 46 - ARNM-1-2

Advances in Radiotherapy
& Nuclear Medicine SUVmax relating to patient and tumor factors

Table 1. Distribution of study population as per organ system, anatomical site, histology, and tumor differentiation grade
Variables Sites Histology Number as per histology Number as per site Total number of
patients as per system
System
Gastrointestinal Esophagus SCC 18 18 26
Gastroesophageal junction Adenocarcinoma 01 01
Rectal Adenocarcinoma 06 06
Anal SCC 01 01
Gynecological Cervix SCC 28 32 32
Adenocarcinoma 03
SCLC 01
Head and neck Nasopharynx SCC 03 17 17
Oropharynx SCC 03
Hypopharynx SCC 02
Larynx SCC 04
Oral Cavity SCC 04
CUPS Neck SCC 01
Thoracic Lung SCC 19 42 42
Adenocarcinoma 18
SCLC 05
Total 117
Abbreviations: CUPS: Carcinoma of unknown primary with secondaries; SCC: Squamous cell carcinoma; SCLC: Small-cell lung carcinoma.

Table 2. Distribution as tumor differentiation grade in posterior tumor locations, larger tumor sizes, and lymph
squamous cell carcinoma and adenocarcinoma node metastasis .
[8]
Histology Grades Number as per grades Similar to the previous studies, our study primarily aimed
Squamous cell carcinoma WD 18 to analyze the correlation of various clinicopathological
MD 45 parameters across different cancer sites with SUV .
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Interestingly, our findings indicate that only histology
PD 20 demonstrated a significant correlation with SUV .
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Adenocarcinoma WD 06 However, other parameters such as age, gender, system (GI,
MD 08 gynecological, thoracic, or head and neck), grade, and stage
PD 14 showed no statistically significant association with SUV .
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Total 111 Poorly differentiated tumors are known for their
Abbreviations: MD: Moderately-differentiated; high proliferation rates, theoretically implying a higher
PD: Poorly-differentiated; WD: Well-differentiated. uptake of radioactive isotopes. However, the correlation
between the SUV and tumor differentiation remains a
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pathological, and tumor-related factors across various topic of controversy. Some studies [10-13] have demonstrated
cancer sites. The literature does not provide evidence that significant connections between SUV and tumor
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suggests any significant variation in SUV values with age differentiation. However, in studies conducted by Dylan
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or gender. In terms of pathological characteristics, a study et al. and Chen and Xue Zhen , the correlation between
[15]
[14]
on lung cancer revealed a positive correlation between grades of tumor differentiation and SUV was not found to
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SUV and tumor size, with squamous cell carcinoma be significant in lung cancer. Moreover, some studies have
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exhibiting significantly higher values compared to other reported high FDG uptake with a poorer prognosis [16-18] ,
histologies . On the contrary, a separate study found no while others have found no association between FDG
[9]
statistically significant differences between tumor size or uptake and overall survival [19,20] . Consequently, FDG uptake
degree of differentiation and SUV in TSCC. However, is not recommended as a measure for risk stratification
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the reported SUV was higher among male patients with neither in the American Joint Committee on Cancer
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Volume 1 Issue 2 (2024) 4 https://doi.org/10.36922/arnm.2032