Page 56 - ARNM-2-1

Advances in Radiotherapy &

Nuclear Medicine

CASE REPORT
Cross-sectional imaging in symmetrical

bilateral extranodal recurrence of follicular
lymphoma: A case report

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1
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Cesare Oliveti *, Barbara Catalfamo , Annachiara Mollace ,
Claudia Italia Maria De Santis , Roberta Mancini , Giuseppe Lucio Cascini ,
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1
1
and Francesco Manti 1
1 Department of Experimental and Clinical Medicine, Division of Radiology, Magna Graecia University of
Catanzaro Azienda Ospedaliero-Universitaria Renato Dulbecco, Catanzaro, Calabria, Italy
2 Department of Diagnostic Imaging Nuclear Medicine Unit, Magna Graecia University of Catanzaro,
Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Calabria, Italy

Abstract

Follicular lymphoma (FL) constitutes nearly 30% of all lymphomas, making it the
second most prevalent B-cell lymphoma. It exhibits an indolent course within the
spectrum of non-Hodgkin lymphoma, with variable 5-year progression-free survival
rates. Histologically graded 1–3, FL primarily affects bone marrow and lymphoid
organs but may also involve extranodal tissues, such as bilateral muscle tissue. This
report outlines the diagnostic challenges associated with disease recurrence in
such unusual locations, emphasizing the need for vigilance among clinicians and

*Corresponding author: radiologists. Through imaging and biopsy, we confirmed recurrence in the patient.
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Cesare Oliveti The study highlights the role of F-FDG PET/CT in detecting uncommon FL sites and
(cesare.oliveti.1990@gmail.com) guiding treatment decisions while emphasizing the importance of multidisciplinary
Citation: Oliveti C, Catalfamo care for optimal patient management.
B, Mollace A, et al. Cross-
sectional imaging in symmetrical
bilateral extranodal recurrence Keywords: Ultrasound; Follicular lymphoma; Computed tomography; F-FDG PET/CT;
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of follicular lymphoma: A case
report. Adv Radiother Nucl Med. Extranodal
2024;2(1):2828.
https://doi.org/10.36922/arnm.2828
Received: January 26, 2024
Accepted: March 19, 2024 1. Background
Follicular lymphoma (FL) accounts for nearly 30% of all lymphomas, making it the
Published Online: March 27, 2024
second most prevalent B-cell lymphoma. FL typically exhibits a clinically indolent course
1
Copyright: © 2024 Author(s). within the spectrum of non-Hodgkin lymphoma (NHL) owing to its slow-growing
This is an Open-Access article
distributed under the terms of the nature, derived from B cells. The 5-year progression-free survival rates, categorized by
Creative Commons Attribution risk factors, are as follows: low risk (0 risk factors): 80%; intermediate risk (1–2 risk
License, permitting distribution,
and reproduction in any medium, factors): 51%; high risk (3–5 risk factors): 19%. Histologically, FL is stratified into
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provided the original work is grades 1–3, signifying an increasing abundance of lymphoma cells or blasts. While FL
properly cited. predominantly affects bone marrow and lymphoid organs, occasional involvement of
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Publisher’s Note: AccScience extranodal tissues and organs occurs, as observed in our clinical case involving bilateral
Publishing remains neutral with muscle tissue. This case report aims to elucidate the challenging diagnostic process of
regard to jurisdictional claims in
published maps and institutional disease recurrence in this atypical location and to alert clinicians and radiologists to the
affiliations potential rare extranodal manifestations of FL.

Volume 2 Issue 1 (2024) 1 https://doi.org/10.36922/arnm.2828