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Advances in Radiotherapy
& Nuclear Medicine CFR-PEEK: A systematic review

Figure 1. PRISMA chart depicting the workflow of article extraction and selection

the results. An overview of the included studies, objectives, 3.2. Intraoperative and postoperative complications
and other relevant information is included in Table 1, 3.2.1. Cerebrospinal fluid (CSF)-related complications
whereas characteristic data of the patient population of
each study is included in Table 2. Patient complications are CSF leaks were assessed in two studies and this data was
reported in Table 3. pooled and showed that CSF leaks occurred in 2.01%
(8/399) of patients (95% CI, 0.95 – 3.07). All reported
5,10
From the 9 included studies, there were 671 patients CSF leaks were subsequently revised surgically.
with a wide range of surgical indications. Of the 671
included patients, 392 were male, and 279 were female, 3.2.2. Wound-related complications
with an average age at the time of surgery of 61.1 years. Data on wound complications due to surgical site
From the studies that categorized the spine tumors, infections, atrophic wound healing disorder, and wound
83.1% (423/509) were metastatic and 16.9% (86/509) breakdown were aggregated. The data pooled from the
were primary. 9-11,13,15,16 The most common metastases were seven studies showed that 8.31% (51/614) of patients
from the breast, lung (both small cell and non-small cell), (95% CI, 6.23 – 10.39) had one of the three types of
prostate, and renal cell. wound complications. 5,10-12,14-16 Multiple types of wound

Volume 2 Issue 2 (2024) 3 doi: 10.36922/arnm.3130