Page 45 - BH-2-1

Brain & Heart Practical tips for AD and PD

deficits is a common denominator in both neurologic Ethics approval and consent to participate
conditions, the trajectories of functional deterioration of
these conditions are distinctly demarcated. The utilization This study was approved by the local Ethics Committee
of tools like BDRS facilitates a deeper understanding of the of Mersin University (MEU.2013-304, October 10 2013).
nuanced behavioral and functional manifestations unique Written informed consent form was obtained from all
participants.
to each disorder. AD typically presents with a progressive
decline in daily functioning, including ADLs and Consent for publication
instrumental ADLs (IADLs), which involve widespread
cortical involvement. Conversely, PD-D often has a There is no identifying information of the patients that
relatively preserved functional capacity in the early stages, appear in writing or within photograph.
reflecting its etiological link to subcortical pathology, Availability of data
but later manifests motor and non-motor symptoms that
significantly impact on independence. This differentiation The data used in this paper were obtained from a case-
in functional decline has profound implications for clinical sensitive database that requires an institutional or
decision-making, as it guides tailored interventions and physician-based subscription. Data used in this work are
care planning. By recognizing the divergent trajectories available from the corresponding author on reasonable
of functional decline, clinicians can refine diagnostic request.
accuracy and formulate personalized treatment strategies.
This approach, augmented by the promises of big data and References
patient-centered care, culminates in enhanced outcomes 1. Perl DP, Olanow CW, Calne D, 1998, Alzheimer’s disease
and improved quality of life for individuals grappling with and Parkinson’s disease: Distinct entities or extremes of a
the multifaceted challenges of dementia. In embracing spectrum of neurodegeneration? Ann Neurol, 44: S19–S31.
this comprehensive approach, health-care providers can https://doi.org/10.1002/ana.410440705
navigate the complex landscape of AD and PD-D more 2. Ballard C, Gauthier S, Corbett A, et al., 2011, Alzheimer’s
effectively, providing not only early diagnosis but also disease. Lancet, 377: 1019–1031.
optimizing ongoing care and support to enhance the lives
of those affected by these devastating conditions. In the https://doi.org/10.1016/S0140-6736(10)61349-9
future, new prospective studies involving larger patient 3. Hardy J, Selkoe DJ, 2002, The amyloid hypothesis of
cohorts should be conducted to further dissect their Alzheimer’s disease: Progress and problems on the road to
differences. therapeutics. Science, 297: 353–356.
https://doi.org/10.1126/science.1072994
Acknowledgments
4. Gurvit H, Emre M, Tinaz S, et al., 2008, The prevalence of
None. dementia in an urban Turkish population. Am J Alzheimers
Dis Other Demen, 23: 67–76.
Funding
https://doi.org/10.1177/1533317507310570
None. 5. Jack CR Jr., Knopman DS, Jagust WJ, et al., 2013, Tracking
Conflict of interest pathophysiological processes in Alzheimer’s disease: An
updated hypothetical model of dynamic biomarkers. Lancet
The authors declare that there are no conflicts of interest. Neurol, 12: 207–216.
https://doi.org/10.1016/S1474-4422(12)70291-0
Author contributions
6. Wardlaw JM, Smith C, Dichgans M, 2013, Mechanisms
Conceptualization: Serhan Karakiliç, Nevra Öksüz, Aynur of sporadic cerebral small vessel disease: Insights from
Özge neuroimaging. Lancet Neurol, 12: 483–497.
Formal analysis: Asena Ayça Özdemir https://doi.org/10.1016/S1474-4422(13)70060-7
Investigation: Serhan Karakiliç, Nevra Öksüz, Reza Ghouri 7. Greicius MD, Srivastava G, Reiss AL, et al., 2004, Default-
mode network activity distinguishes Alzheimer’s disease
Methodology: Aynur Özge from healthy aging: Evidence from functional MRI. Proc

Writing – original draft: Serhan Karakiliç, Nevra Öksüz, Natl Acad Sci U S A, 101: 4637–4642.
Reza Ghouri, Aynur Özge https://doi.org/10.1073/pnas.0308627101
Writing – review and editing: Nevra Öksüz, Aynur Özge 8. Aarsland D, Creese B, Politis M, et al., 2017, Cognitive

Volume 2 Issue 1 (2024) 9 https://doi.org/10.36922/bh.1712