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Brain & Heart Adenosine cardiac arrest in aneurysm surgery

methylxanthines, potentially leading to elevated levels and meta analysis. JAMA Neurol. 2019;76:588-597.
24
of adenosine. As such, these agents are considered doi: 10.1001/jamaneurol.2019.0006
relative contraindications when used in conjunction with
adenosine administration. 2. Tsao CW, Aday AW, Almarzooq ZI, et al. Heart disease and
stroke statistics-2023 update: A report from the American
4. Conclusion Heart Association [published correction appears in
Circulation. 2023;147:e622]. Circulation. 2023;147:e93-e621.
In our experience, AiCS at recommended doses effectively doi: 10.1161/CIR.000000000000112
and safely facilitated optimal surgical conditions for the
clipping of intracranial aneurysms. With careful patient 3. Meling TR, Romundstad L, Niemi G, et al. Adenosine-
assisted clipping of intracranial aneurysms. Neurosurg Rev.
selection, proper communication between the neurosurgeon 2018;41:585-592.
and anesthesiologist, and optimal anesthetic management,
this technique mitigated the risk of intraoperative doi: 10.1007/s10143-017-0896-y
aneurysmal rupture during surgical dissection. 4. Luostarinen T, Takala RS, Niemi TT, et al. Adenosine-
induced cardiac arrest during intraoperative cerebral
Acknowledgments aneurysm rupture. World Neurosurg. 2010;73(2):79-83;
discussion e79.
None.
doi: 10.1016/j.surneu.2009.06.018
Funding 5. Bebawy JF, Gupta DK, Bendok BR, et al. Adenosine-induced
None. flow arrest to facilitate intracranial aneurysm clip ligation:
Dose-response data and safety profile. Anesth Analg.
Conflict of interest 2010;110:1406-1411.

The authors declare that they have no competing interests. doi: 10.1213/ANE.0b013e3181d65bf5
6. Guinn NR, McDonagh DL, Borel CO, et al. Adenosine-
Author contributions induced transient asystole for intracranial aneurysm
Conceptualization: Geraldine Raphaela B. Jose, Cristina C. surgery: A retrospective review. J Neurosurg Anesthesiol.
2011;23:35-40.
Arcinue-Gomez
Investigation: Geraldine Raphaela B. Jose, Gerardo D. doi: 10.1097/ANA.0b013e3181ef2b11
Legaspi 7. Britz GW. Adenosine-induced transient asystole. Methodist
Methodology: Cristina C. Arcinue-Gomez Debakey Cardiovasc J. 2014;10(4):220-223.
Writing – original draft: Cristina C. Arcinue-Gomez, doi: 10.14797/mdcj-10-4-220
Lalaine O. Abainza, Katrina H. Figueroa-Piscawen,
Christian Rofem P. Quirimit, Glenn C. Chavez 8. Hoh BL, Ko NU, Amin-Hanjani S, et al. Guideline for the
Writing – review & editing: Geraldine Raphaela B. Jose, management of patients with aneurysmal subarachnoid
hemorrhage: A guideline from the American heart
Cristina C. Arcinue-Gomez association/American Stroke Association. Stroke.
2023;54(7):e314-e370.
Ethics approval and consent to participate
doi: 10.1161/STR.0000000000000436
Not applicable.
9. Intarakhao P, Thairawan P, Tewaritrueangsri A,
Consent for publication Pojanasupawun S. Low-dose adenosine-induced transient
asystole during intracranial aneurysm surgery. Surg Neurol
Not applicable. Int. 2020;11:235.
Availability of data doi: 10.25259/SNI_79_2020
10. Baker AB, Bookallil MJ, Lloyd G. Intentional asystole
Data are available from the corresponding author upon during endoluminal thoracic aortic surgery without
request. cardiopulmonary bypass. Br J Anaesth. 1997;78:444-448.

References doi: 10.1093/bja/78.4.444
1. Etminan N, Chang HS, Hackenberg K, et al. Worldwide 11. Belloni FL, Wang J, Hintze TH. Adenosine causes
incidence of aneurysmal subarachnoid hemorrhage bradycardia in pacing-induced cardiac failure. Circulation.
according to region, time period, blood pressure, and 1992;85:1118-1124.
smoking prevalence in the population: A systematic review doi: 10.1161/01.cir.85.3.1118

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