Page 45 - EJMO-9-2

Eurasian Journal of
Medicine and Oncology Gut microbiome effects on obesity

distribution with obesity: Causation or association? Postgrad 159. Wang Y, Wang H, Howard AG, et al. Circulating short-chain
Med. 2015;127(8):863-868. fatty acids are positively associated with adiposity measures
doi: 10.1080/00325481.2015.1098519 in Chinese adults. Nutrients. 2020;12(7):2127.
148. Ng SC, Xu Z, Mak JWY, et al. Microbiota engraftment after doi: 10.3390/nu12072127
faecal microbiota transplantation in obese subjects with 160. Martínez-Cuesta MC, del Campo R, Garriga-García M,
type 2 diabetes: A 24-week, double-blind, randomised Peláez C, Requena T. Taxonomic characterization and short-
controlled trial. Gut. 2022;71(4):716-723. chain fatty acids production of the obese microbiota. Front
doi: 10.1136/gutjnl-2020-323617 Cell Infect Microbiol. 2021;11:598093.
149. Rasmussen TS, Mentzel CMJ, Kot W, et al. Faecal virome doi: 10.3389/fcimb.2021.598093
transplantation decreases symptoms of type 2 diabetes and 161. Yamamura R, Nakamura K, Ukawa S, et al. Fecal short-
obesity in a murine model. Gut. 2020;69:2122-2130. chain fatty acids and obesity in a community-based Japanese
doi: 10.1136/gutjnl-2019-320005 population: The DOSANCO Health Study. Obes Res Clin
Pract. 2021;15(4):345-350.
150. Zhao L. The gut microbiota and obesity: From correlation to
causality. Nat Rev Microbiol. 2013;11(9):639-647. doi: 10.1016/j.orcp.2021.06.003
doi: 10.1038/nrmicro3089 162. Farup PG, Valeur J. Changes in faecal short-chain fatty
acids after weight-loss interventions in subjects with morbid
151. Sonnenburg JL, Bäckhed F. Diet-microbiota interactions obesity. Nutrients. 2020;12(3):802.
as moderators of human metabolism. Nature.
2016;535(7610):56-64. doi: 10.3390/nu12030802
doi: 10.1038/nature18846 163. Ecklu-Mensah G, Choo-Kang C, Maseng MG, et al. Gut
microbiota and fecal short chain fatty acids differ with
152. Gomes AC, Hoffmann C, Mota JF. The human gut adiposity and country of origin: The METS-microbiome
microbiota: Metabolism and perspective in obesity. Gut study. Nat Commun. 2023;14:5160.
Microbes. 2018;9(4):308-325.
doi: 10.1038/s41467-023-40874-x
doi: 10.1080/19490976.2018.1465157
164. Barczyńska R, Litwin M, Sliżewska K, et al. Bacterial
153. Boscaini S, Leigh SJ, Lavelle A, et al. Microbiota and body
weight control: Weight watchers within? Mol Metab. microbiota and fatty acids in the faeces of overweight and
2021;57:101427. obese children. Pol J Microbiol. 2018;67(3):339-345.
doi: 10.21307/pjm-2018-041
doi: 10.1016/j.molmet.2021.101427
165. Fang W, Xue H, Chen X, Chen K, Ling W. Supplementation
154. Dalile B, Van Oudenhove L, Vervliet B, Verbeke K.
The role of short-chain fatty acids in microbiota-gut- with sodium butyrate modulates the composition of the gut
brain communication. Nat Rev Gastroenterol Hepatol. microbiota and ameliorates high-fat diet-induced obesity in
2019;16(8):461-478. mice. J Nutr. 2019;149(5):747-754.
doi: 10.1038/s41575-019-0157-3 doi: 10.1093/jn/nxy324
155. Pascale A, Marchesi N, Marelli C, et al. Microbiota and 166. Boets E, Gomand SV, Deroover L, et al. Systemic availability
metabolic diseases. Endocrine. 2018;61(3):357-371. and metabolism of colonic‐derived short‐chain fatty
acids in healthy subjects: A stable isotope study. J Physiol.
doi: 10.1007/s12020-018-1605-5 2017;595(2):541-555.
156. Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. doi: 10.1113/JP272613
From dietary fiber to host physiology: Short-chain fatty acids
as key bacterial metabolites. Cell. 2016;165(6):1332-1345. 167. den Besten G, Bleeker A, Gerding A, et al. Short-chain fatty
acids protect against high-fat diet-induced obesity via a
doi: 10.1016/j.cell.2016.05.041 PPARγ-dependent switch from lipogenesis to fat oxidation.
157. Chambers ES, Preston T, Frost G, Morrison DJ. Role of gut Diabetes. 2015;64(7):2398-2408.
microbiota-generated short-chain fatty acids in metabolic doi: 10.2337/db14-1213
and cardiovascular health. Curr Nutr Rep. 2018;7(4):198-206.
168. Collins L, Costello RA. Glucagon-like peptide-1 receptor
doi: 10.1007/s13668-018-0248-8 agonists. In: StatPearls. StatPearls Publishing; 2024. Available
158. Kennedy A, Martinez K, Schmidt S, Mandrup S, LaPoint K, from: https://www.ncbi.nlm.nih.gov/books/NBK551568
24
McIntosh M. Antiobesity mechanisms of action of conjugated [Last accessed on 2024 Dec .
linoleic acid. J Nutr Biochem. 2010;21(3):171-179.
169. Senior M. After GLP-1, what’s next for weight loss? Nat
doi: 10.1016/j.jnutbio.2009.08.003 Biotechnol. 2023;41(6):740-743.

Volume 9 Issue 2 (2025) 37 doi: 10.36922/ejmo.8318