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Global Health Economics and
            Sustainability
                                                                                        COVID-19 changed our world



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            Figure 4. Different COVID-19 variants from different countries. (A) Structure of COVID-19, including the component of genes of COVID-19; (B) Variant
            of concern. Image created by the authors


            people who were older, male, or obese (Docherty  et  al.,   to curb the spread of COVID-19. These measures were
            2020), or who suffered from pulmonary hypertension,   effective in preventing infections (Coccia, 2021) but they
            chronic cardiac conditions (Pagnesi et al., 2020), diabetes,   also exerted a significant negative impact. As  Figure  6
            chronic obstructive pulmonary disease, liver diseases, and   illustrates, the lockdowns affected many sectors including
            chronic kidney disease (Iaccarino  et al., 2020). Patients   business (Donthu & Gustafsson, 2020), economy, health,
            at lower risk of death also often experienced persistent   and education (Jiang et al., 2021; Shastri et al., 2020; Nicola
            symptoms, and up to 70% of such individuals exhibited   et al., 2020; Haleem et al., 2020). The sections that follow
            organ damage 4  months after their initial symptoms.   detail how strict lockdowns adversely impacted diverse
            The affected organs included the heart, lungs, kidneys,   aspects of society and affected resources.
            liver, pancreas, and spleen (Dennis et al., 2021). Vaccines
            significantly reduced mortality rates but debates persist   4.1. Mental and emotional health
            about whether  COVID-19 can be eradicated or could   Mental health is defined as the state of well-being in which
            reemerge (Murray, 2022).                           individuals can manage daily challenges and contribute
                                                               constructively  to  society (World Health Organization,
            4. Impact of COVID-19                              2004; Galderisi  et al., 2015). The COVID-19 pandemic

            Governments worldwide implemented strict lockdowns   disrupted this balance, primarily because preventive
            when the pandemic began, and self-isolation was mandated   measures such as lockdowns confined people to their


            Volume 3 Issue 1 (2025)                         43                       https://doi.org/10.36922/ghes.3992
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