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Gene & Protein in Disease

PERSPECTIVE ARTICLE
Constructing human genetic disease database

in Bangladesh

Fariya Akter , Yusha Araf , Saeed Anwar , Mohammad Jakir Hosen *, and
1
2
2
3
Chunfu Zheng *
4,5
1 Biotechnology Program, Department of Mathematics and Natural Sciences, School of Data and
Sciences, BRAC University, Dhaka, Bangladesh
2 Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal
University of Science and Technology, Sylhet, Bangladesh
3 Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta,
Edmonton, Alberta, Canada
4 Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
5 Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary,
Alberta, Canada

Abstract
In the advent of technological revolution, genetic interaction has become a crucial
aspect in the understanding of any diseases. Information on individual genetic
variation is now used in translational genomics to implement precise diagnosis
and personalized medicine. Finding causal genes for genetic diseases or exploring
interaction of genes in diseases with genetic predisposition is the first step to getting
insights into such diseases. The human genome project made a paradigm shift in
thinking, especially in the developed countries affected by non-communicable
*Corresponding authors: diseases. Some cutting-edge technologies, including gene therapy and genome
Mohammad Jakir Hosen editing, hold the promise in better diagnosis and treatment of common to rare
(Jakir-gen@sust.edu)
Chunfu Zheng genetic diseases. Scientific communities are trying hard to accumulate all the
(zheng.alan@hotmail.com) genetic disease information from publicly available platforms. A genetic disease
Citation: Akter F, Araf Y, Anwar S, database of a country serves as a depository. Many developed and a few developing
et al., 2022, Constructing human countries have already developed genetic disease databases, which could benefit
genetic disease database in early diagnosis and proper patient management. Unfortunately, Bangladesh is
Bangladesh. Gene Protein Dis,
1(1): 78. lagging behind in this aspect. It is imperative to develop genetic disease database in
https://doi.org/10.36922/gpd.v1i1.78 Bangladesh because of its large population of patients with genetic disease. In this
review, we discuss the reasons for constructing a genetic disease database and how
Received: April 28, 2022
Accepted: June 22, 2022 this database can help to fight against challenges arising from the genetic diseases
Published Online: June 29, 2022 in Bangladesh.
Copyright: © 2022 Author(s).
This is an Open Access article
distributed under the terms of the Keywords: Genetic disease; Database; Bangladesh
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited. 1. Introduction
Publisher’s Note: AccScience Genetic disease or disorder is caused by the mutation(s) in one or more genes or anomalies
Publishing remains neutral with in the chromosome . The precise diagnosis, control, and management of a genetic disease
[1]
regard to jurisdictional claims in [2]
published maps and institutional depend on the identification of causal variants in the genome . The breakthrough discovery
affiliations. of the human genome project allows scientists to understand the disease better. With

Volume 1 Issue 1 (2022) 1 https://doi.org/10.36922/gpd.v1i1.78