Page 74 - GPD-3-1

Gene & Protein in Disease

COMMENTARY
Identification of stress-induced epigenetic

methylation onto dopamine D2 gene and
neurological and behavioral consequences

1
Kenneth Blum 1,2,3,4,5,6,7,8,9 *, Abdalla Bowirrat , David Baron , Igor Elman 9,10 ,
2
11
13
12
Milan T. Makale , Jean Lud Cadet , Panayotis K. Thanos , Colin Hanna ,
13
15
13
Rania Ahmed , Marjorie C. Gondre-Lewis , Catherine A. Dennen , Eric
14
16
R. Braverman , Diwanshu Soni , Paul Carney , Jag Khalsa , Edward J.
6
2
17
Modestino , Debmalya Barh 7,19 , Debasis Bagchi , Rajendra D. Badgaiyan ,
21
20
18
22
6
24
23
Thomas McLaughlin , Rene Cortese , Mauro Ceccanti , Kevin T. Murphy ,
Ashim Gupta , Miles T. Makale , Keerthy Sunder 9,27 , Mark S.Gold 28
25
26
1 Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel
2 Division of Addiction Research & Education, Center for Sports, Exercise & Mental Health, Western
University of the Health Sciences, Pomona, CA, United States of America
3 Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary
4 Department of Psychiatry, University of Vermont, Burlington, VT 05405, United States of America
5 Department of Psychiatry, Wright University Boonshoft School of Medicine, Dayton, OH, United
States of America
6 Division of Nutrigenomics, The Kenneth Blum Behavioral Neurogenetic Institute, Austin, TX United
States of America
7 Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied
Biotechnology, Nonakuri, Purba Medinipur, West Bengal, India
8 Department of Nutrigenomic Research, Victory Nutrition International, Inc., Bonita Springs, FL,
United States of America
*Corresponding author: 9 Division of Personalized Neuromodulation Research, Sunder Foundation, Palm Springs, CA,
Kenneth Blum United States of America
(drd2gene@gmail.com)
10 Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, United States of America
Citation: Blum K, Bowirrat A, 11
Baron D, et al. Identification Department of Radiation Medicine and Applied Sciences, UC San Diego, 3855 Health Sciences
of stress-induced epigenetic Drive, La Jolla, CA 92093-0819, United States of America
methylation onto dopamine D2 gene 12 Molecular Neuropsychiatry Research Branch, National Institute on Drug Abuse, National Institutes
and neurological and behavioral of Health, Bethesda, MD., United States of America
consequences. Gene Protein Dis.
2024;3(1):1966. 13 Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research
https://doi.org/10.36922/gpd.1966 Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine
and Biosciences, State University of New York at Buffalo, Buffalo, NY, United States of America;
Received: September 29, 2023 Department of Psychology, State University of New York at Buffalo, Buffalo, NY., United States of
Accepted: December 14, 2023 America
Published Online: March 29, 2024
14 Department of Anatomy, Howard University College of Medicine, and Developmental
Copyright: © 2024 Author(s). Neuropsychopharmacology Laboratory, Howard University College of Medicine, Washington D.C.,
This is an Open-Access article United States of America
distributed under the terms of the
Creative Commons Attribution 15 Department of Family Medicine, Jefferson Health Northeast, Philadelphia, PA, United States of
License, permitting distribution, America
and reproduction in any medium, 16 Division Pediatric Neurology, University of Missouri, School of Medicine, Columbia, MO., United
provided the original work is States of America
properly cited.
17 Department of Microbiology, Immunology and Tropical Medicine, George Washington University,
Publisher’s Note: AccScience School of Medicine and Health Sciences, Washington, DC, United States of America
Publishing remains neutral with 18
regard to jurisdictional claims in Department of Psychology, Curry College, Milton, MA., United States of America
published maps and institutional 19 Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade
affiliations. Federal de Minas Gerais, Belo Horizonte, Brazil
Volume 3 Issue 1 (2024) 1 https://doi.org/10.36922/gpd.1966