Page 85 - GPD-3-2

Gene & Protein in Disease

REVIEW ARTICLE
Tiny messengers, big results: A review

of exosome-mediated treatments and
considerations in dermatology

Dorra Guermazi * , Saira Khan , Asghar Shah , and Elie Saliba *
1†
3
2†
1
1 Department of Dermatology, Division of Biology and Medicine, Brown University, Providence,
Rhode Island, United States of America
2 Department of Dermatology, College of Medicine and Life Sciences, University of Toledo, Toledo,
Ohio, United States of America
3 Department of Dermatology, The Warren Alpert Medical School, Brown University, Providence,
Rhode Island, United States of America

Abstract

Exosomes are small extracellular vesicles that play an important role in intercellular
communication by transporting proteins, lipids, and nucleic acids between cells.
They have emerged as relevant research areas due to their involvement in regulating
various physiological and pathological processes. This review explores the potential
applications of exosome-based therapies in dermatology and examines the safety
aspects of these treatments. Past research has demonstrated that exosomes may
† These authors contributed equally
to this work. effectively treat conditions such as alopecia and accelerate wound healing by
stimulating hair follicle growth and enhancing tissue regeneration. Studies have
*Corresponding authors:
Dorra Guermazi shown that exosomes can promote the proliferation of dermal papilla cells and hair
(dorra_guermazi@brown.edu) follicle growth in cases of alopecia. They also accelerate wound healing by modulating
Elie Saliba processes involved in inflammation, cell migration, and tissue remodeling. However,
(elie_saliba@brown.edu)
more research is needed to fully characterize the long-term safety profile of
Citation: Guermazi D, Khan exosomes and establish standardized clinical protocols. Both human-derived and
S, Shah A, Saliba E. Tiny
messengers, big results: A review plant-derived exosomes appear to have favorable safety profiles based on current
of exosome-mediated treatments evidence, though plant sources may offer advantages in terms of production and
and considerations in dermatology. biocompatibility. Continued exploration of exosomes’ mechanisms and potential
Gene Protein Dis. 2024;3(2):3230.
doi: 10.36922/gpd.3230 risks will optimize these innovations and offer safe, effective exosome treatments
to patients. While further research is warranted, current findings provide valuable
Received: March 21, 2024 insights into the applications of exosome therapy for dermatological conditions and
Accepted: May 17, 2024 its emerging role in precision medicine.
Published Online: July 4, 2024
Copyright: © 2024 Author(s). Keywords: Exosomes; Alopecia; Wound healing; Tissue regeneration; Regenerative
This is an Open-Access article medicine
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is 1. Introduction
properly cited.
1.1. Defining exosomes and their modes of action
Publisher’s Note: AccScience
Publishing remains neutral with Exosomes, which are small extracellular vesicles, have become a focal point of
regard to jurisdictional claims in 1
published maps and institutional scientific exploration due to their importance in intercellular communication. These
affiliations. minuscule entities, secreted by a variety of cell types, play a crucial role in orchestrating

Volume 3 Issue 2 (2024) 1 doi: 10.36922/gpd.3230