Page 80 - GPD-3-2
P. 80
Gene & Protein in Disease Opportunities and challenges of HIF-1 in cancer
37. Kasuya K. Hypoxia-inducible factor-1α expression and 48. Marin-Hernandez A, Gallardo-Perez J, Ralph S, Rodriguez-
gemcitabine chemotherapy for pancreatic cancer. Oncol Enriquez S, Moreno-Sanchez R. HIF-1α modulates energy
Rep. 2011;26:1399-1406. metabolism in cancer cells by inducing over-expression
doi: 10.3892/or.2011.1457 of specific glycolytic isoforms. Mini Rev Med Chem.
2009;9(9):1084-1101.
38. Mamlouk S, Wielockx B. Hypoxia-inducible factors
as key regulators of tumor inflammation. Int J Cancer. doi: 10.2174/138955709788922610
2012;132(12):2721-2729. 49. Wojtkowiak JW, Verduzco D, Schramm KJ, Gillies RJ.
doi: 10.1002/ijc.27901 Drug resistance and cellular adaptation to tumor acidic PH
microenvironment. Mol Pharm. 2011;8(6):2032-2038.
39. Arantzazu A, Caro D, Vara A, Julián A, Vidal F,
Landázuri MO. C-Jun and hypoxia-inducible factor doi: 10.1021/mp200292c
1 functionally cooperate in hypoxia-induced gene 50. Spivak-Kroizman TR, Hostetter G, Posner R, et al. Hypoxia
transcription. Mol Cell Biol. 2002;22(1):12-22. triggers hedgehog-mediated tumor-stromal interactions in
doi: 10.1128/mcb.22.1.12-22.2002 pancreatic cancer. Cancer Res. 2013;73(11):3235-3247.
40. Hoesel B, Schmid JA. The complexity of NF-ΚB signaling in doi: 10.1158/0008-5472.can-11-1433
inflammation and cancer. Mol Cancer. 2013;12(1):86. 51. Chafe SC, Lou Y, Sceneay J, et al. Carbonic anhydrase IX
doi: 10.1186/1476-4598-12-86 promotes myeloid-derived suppressor cell mobilization and
establishment of a meta-static niche by stimulating G-CSF
41. Lavecchia A, Di Giovanni C, Cerchia C. Novel inhibitors of production. Cancer Res. 2015;75(6):996-1008.
signal transducer and activator of transcription 3 signaling
pathway: An update on the recent patent literature. Expert doi: 10.1158/0008-5472.can-14-3000
Opin Ther Pat. 2014;24(4):383-400. 52. Lamouille S, Xu J, Derynck R. Molecular mechanisms of
doi: 10.1517/13543776.2014.877443 epithelial-mesenchymal transition. Nat Rev Mol Cell Biol.
2014;15(3):178-196.
42. Zong WX, Edelstein LC, Chen C, Bash J, Gelinas C. The
prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional doi: 10.1038/nrm3758
target of NF-kappa B that blocks TNFalpha -induced 53. Copple BL. Hypoxia stimulates hepatocyte epithelial to
apoptosis. Genes Dev. 1999;13(4):382-387. mesenchymal transition by hypoxia-inducible factor and
doi: 10.1101/gad.13.4.382 transforming growth factor-β-dependent mechanisms.
Liver Int. 2010;30(5):669-682.
43. Jung JE, Lee HG, Cho IH, et al. STAT3 is a potential
modulator of HIF‐1‐mediated VEGF expression in human doi: 10.1111/j.1478-3231.2010.02205.x
renal carcinoma cells. FASEB J. 2005;19(10):1296-1298. 54. Jiang YG, Luo Y, He D, et al. Role of Wnt/β-catenin signaling
doi: 10.1096/fj.04-3099fje pathway in epithelial-mesenchymal transition of human
prostate cancer induced by hypoxia-inducible factor-1α. Int
44. Pawlus MR, Wang L, Hu CJ. STAT3 and HIF1α cooperatively J Urol. 2007;14(11):1034-1039.
activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Oncogene. 2013;33(13):1670-1679. doi: 10.1111/j.1442-2042.2007.01866.x
doi: 10.1038/onc.2013.115 55. Zhang Q, Bai X, Chen W, et al. Wnt/β-catenin signaling
enhances hypoxia-induced epithelial-mesenchymal
45. Noman MZ, Buart S, Pelt JV, et al. The cooperative induction transition in hepatocellular carcinoma via crosstalk with
of hypoxia-inducible factor-1α and STAT3 during hypoxia hif-1α signaling. Carcinogenesis. 2013;34(5):962-973.
induced an impairment of tumor susceptibility to CTL-
mediated cell lysis. J Immunol. 2009;182(6):3510-3521. doi: 10.1093/carcin/bgt027
doi: 10.4049/jimmunol.0800854 56. Bendris N, Arsic N, Lemmers B, Blanchard JM. Cyclin A2,
Rho GTPases and EMT. Small GTPases. 2012;3(4):225-228.
46. Tewari R, Choudhury SR, Ghosh S, Mehta VS, Sen E.
Involvement of TNFα-induced TLR4-NF-ΚB and TLR4– doi: 10.4161/sgtp.20791
HIF-1α feed-forward loops in the regulation of inflammatory 57. Hosseini K, Frenzel A, Fischer‐Friedrich E. EMT induces
responses in glioma. J Mol Med. 2011;90(1):67-80. characteristic changes of Rho GTPases and downstream
doi: 10.1007/s00109-011-0807-6 effectors with a mitosis-specific twist. Phys Biol. 2023;20(6):6001.
47. Zhang JJ. Expression and significance of TLR4 and HIF-1α doi: 10.1088/1478-3975/acf5bd
in pancreatic ductal adenocarcinoma. World J Gastroenterol. 58. Turcotte S. HIF-1alpha MRNA and protein upregulation
2010;16(23):2881.
involves Rho GTPase expression during hypoxia in renal cell
doi: 10.3748/wjg.v16.i23.2881 carcinoma. J Cell Sci. 2003;116(11):2247-2260.
Volume 3 Issue 2 (2024) 13 doi: 10.36922/gpd.3431

