Page 104 - GPD-4-1
P. 104
Gene & Protein in Disease Oral-ERT in PD knockout mice with tobrhGAA
proteins. Biotechnol Adv. 2012;30:434-439. Challenges. Sevilla (Spain): JRC European Commission;
2008. p. 1-148.
doi: 10.1016/j.biotechadv.2011.08.007
66. Lico C, Santi L, Twyman RM, Pezzotti M, Avesani L. The use 78. Lerouge P, Cabanes-Macheteau M, Rayon C, Fischette-
of plants for the production of therapeutic human peptides. Lainé AC, Gomord V, Faye L. N-glycosylation of
Plant Cell Rep. 2012;31:439-451. recombinant pharmaceutical glycoproteins produced
in transgenic plants: Towards an humanisation of plant
doi: 10.1007/s00299-011-1215-7 N-glycans. Plant Mol Biol. 1998;38:31-48.
67. Twyman RM, Ramessar K, Quemada H, Capell T, 79. Stoeger E, Ma JK. Sowing the seeds of success:
Christou P. Plant biotechnology: The importance of being Pharmaceutical proteins from plants. Curr Opin Biotechnol.
accurate. Trends Biotechnol. 2009;27:609-612. 2005;16:167-173.
doi: 10.1016/j.tibtech.2009.08.004 doi: 10.1016/j.copbio.2005.01.005
68. Twyman RM, Stoger E, Schillberg S, Christou P, Fischer R. 80. Gomord V, Fischette AC, Menu-Bouaouiche L, et al. Plant-
Molecular farming in plants: Host systems and expression specific glycosylation patterns in the context of therapeutic
technology. Trends Biotechnol. 2003;21:570-578. protein production. Plant Biotechnol J. 2010;8:564-587.
doi: 10.1016/j.tibtech.2003.10.002 81. Saint-Jore-Dupas C, Faye L, Gomord V. From planta to
69. Kwon K, Verma D, Singh N, Herzog R, Daniell H. Oral pharma with glycosylation in the toolbox. Trends Biotechnol.
delivery of human biopharmaceuticals, autoantigens and 2007;25:317-323.
vaccine antigens bioencapsulated in plant cells. Adv Drug doi: 10.1016/j.tibtech.2007.04.008
Deliv Rev. 2013;65:782-799.
82. Gomord V, Faye L. Posttranslational modification of
doi: 10.1016/j.addr.2012.10.005 therapeutic proteins in plants. Curr Opin Plant Biol.
70. Verma D, Moghimi B, LoDuca PA, et al. Oral delivery of 2004;7:171-181.
bioencapsulated coagulation factor IX prevents inhibitor doi: 10.1016/j.pbi.2004.01.015
formation and fatal anaphylaxis in hemophilia B mice. Proc
Natl Acad Sci U S A. 2010;107:7101-7106. 83. Kermode AR. Mechanisms of intracellular protein transport
and targeting. Crit Rev Plant Sci. 1996;15:285-423.
doi: 10.1073/pnas.0912181107
doi: 10.1038/372055a0
71. Sherman A, Su J, Lin S, Wang X, Herzog RW, Daniell H.
Suppression of inhibitor formation against FVIII in a 84. He X, Galpin JD, Tropak MB, et al. Production of active
murine model of hemophilia A by oral delivery of antigens human glucocerebrosidase in seeds of Arabidopsis thaliana
bioencapsulated in plant cells. Blood. 2014;124:1659-1668. complex-glycan-deficient (cgl) plants. Glycobiology.
doi: 10.1182/blood-2013-10-528737 2012;22:492-503.
72. Boothe J, Nykiforuk C, Shen Y, et al. Seed-based expression doi: 10.1093/glycob/cwr157
system for plant molecular farming. Plant Biotechnol J. 85. Aviezer D, Almon-Brilla EY, Chertkoffa R, Hashmuelia S,
2010;8:588-606. Zimranb A. Novel enzyme replacement therapy for
doi: 10.1111/j.1467-7652.2010.00511.x Gaucher disease: Phase III pivotal clinical trial with plant
cell expressed recombinant glucocerebrosidase (prGCD)-
73. Kwon KC, Daniell H. Low-cost oral delivery of protein taliglucerase alpha. Mol Gen Metab. 2010;99:S9.
drugs bioencapsulated in plant cells. Plant Biotechnol J.
2015;13:1017-1022. 86. Shaaltiel Y, Bartfeld D, Hashmueli S, et al. Production of
glucocerebrosidase with terminal mannose glycans for
doi: 10.1111/pbi.12462 enzyme replacement therapy of Gaucher’s disease using a
74. Kaufman J. The economic potential of plant-made plant cell system. Plant Biotechnol J. 2007;5:579-590.
pharmaceuticals in the manufacture of biologic doi: 10.1111/j.1467-7652.2007.00263.x
pharmaceuticals. J Commercial Biotechnol. 2011;17:173-182.
87. Grabowski GA, Golembo M, Shaaltiel Y. Taliglucerase alfa:
75. Kaiser J. Is the drought over for Pharming? Science. An enzyme replacement therapy using plant cell expression
2008;320:473-475. technology. Mol Genet Metab. 2014;112:1-8.
doi: 10.1126/science.320.5875.473 doi: 10.1016/j.ymgme.2014.02.011
76. Maxmen A. Drug making plant blooms. Nature. 88. Tekoah Y, Shulman A, Kizhner T, et al. Large-scale production
2012;485:160. of pharmaceutical proteins in plant cell culture-the Protalix
doi: 10.1038/485160a experience. Plant Biotechnol J. 2015;13:1199-1208.
77. Spok A, Karner S. Plant made Farming-Opportunities and 89. Shaaltiel Y, Gingis-Velitski S, Tzaban S, Fiks N, Tekoah Y,
Volume 4 Issue 1 (2025) 18 doi: 10.36922/gpd.1760

